Korean J Obstet Gynecol.  2010 Oct;53(10):915-920. 10.5468/kjog.2010.53.10.915.

Serum bisphenol-A concentrations from uterine leiomyoma patients

• Byun JC
• Han MS

• KMID: 1453756
• DOI: http://doi.org/10.5468/kjog.2010.53.10.915

Abstract

OBJECTIVE
To investigate how many leiomyoma patients are exposed to bisphenol-A (BPA) and whether the serum concentration of BPA is related to leiomyoma growth.
METHODS
Total 131 patients were recruited for measuring BPA. Initially, leiomyoma patients were divided into three groups, mild (n=38), moderate (n=33), and severe (n=30) according to the size of the leiomyomas. The control (n=30) group was defined as having no leiomyomas. The identification and diameter measurements of leiomyomas was performed by transvaginal ultrasonography. Serum BPA concentrations were measured by enzyme linked immunosorbent assay.
RESULTS
BPA was detected in 83.9% out of 131 samples totally, and 83.1% out of 101 leiomyoma patients. In detail, the detection rates of serum BPA were 86.7% in control group, 71.1% in mild group, 84.9% in moderate group, and 96.7% in severe group. The mean BPA concentrations in the control group was 0.557+/-0.086 ng/mL and those in the leiomyoma groups were 0.273+/-0.052 ng/mL (mild), 0.336+/-0.063 ng/mL (moderate), and 0.636+/-0.075 ng/mL (severe) (P=0.0003). Values are mean+/-standard error. Conclusions: The detection rate of serum BPA in control and leiomyoma groups were 86.7% and 83.1% respectively. However, there was no statistical significance of serum BPA concentrations between control and leiomyoma groups. To verify the effect of BPA on the leiomyoma growth, close and sequential monitoring for the person who have exposure risk is recommended.

Keyword

Leiomyoma; Bisphenol-A; Enzyme linked immunosorbent assay

MeSH Terms

Enzyme-Linked Immunosorbent Assay
Humans
Leiomyoma

Figure

• 

  Fig. 1 Bisphenol-A (BPA) levels in each groups.

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