Korean J Pathol.  2011 Apr;45(2):217-222. 10.4132/KoreanJPathol.2011.45.2.217.

Fine Needle Aspiration Cytologic Findings of Angiosarcoma: Report of Two Cases

• Ji JX
• Chu YC
• Kim L
• Choi SJ
• Park IS
• Han JY
• Kim JM
• Kim KH
• Song JY

• KMID: 1443759
• DOI: http://doi.org/10.4132/KoreanJPathol.2011.45.2.217

Abstract

Angiosarcoma is a rare malignant vascular neoplasm which can arise in any part of the body. Specific recognition of this neoplasm in cytological specimens is difficult in the absence of an ancillary method. Herein, we present the cytologic findings of two cases of angiosarcomas diagnosed on fine needle aspiration cytology. One case is a recurred angiosarcoma in the left chest wall and the other case is a lymphedema-associated angiosarcoma in the left lower leg. The cytologic findings of both cases are similar. Cytologic features that identified this neoplasm as an angiosarcoma included arborizing microtissue fragments, irregular anastomosing vascular spaces lined by atypical cells, microacini, intracytoplasmic lumen, and intracellular red blood cells, marked cell discohesiveness, spindle to ovoid, irregular, hyperchromatic nuclei, and elongated cytoplasmic processes with indistinct borders. This report emphasizes that when aspiration smears show vasoformative features in a bloody background, angiosarcoma should be included in the differential diagnosis.

Keyword

Angiosarcoma; Fine needle aspiration cytology

MeSH Terms

Biopsy, Fine-Needle
Cytoplasm
Diagnosis, Differential
Erythrocytes
Hemangiosarcoma
Leg
Thoracic Wall
Vascular Neoplasms