J Korean Soc Radiol.  2011 Aug;65(2):133-138. 10.3348/jksr.2011.65.2.133.

Successful Use of Magnetic Resonance-Guided Focused Ultrasound Surgery for Long-Term Pain Palliation in a Patient Suffering from Metastatic Bone Tumor

• Lee JE
• Yoon SW
• Kim KA
• Lee JT
• Shay L
• Lee KS

• KMID: 1443475
• DOI: http://doi.org/10.3348/jksr.2011.65.2.133

Abstract

Magnetic Resonance-guided Focused Ultrasound Surgery (MRgFUS) is a clinically effective, non-invasive treatment for thermal ablation of various soft tissue tumors, and is effective in pain palliation following radiation therapy, as has been demonstrated in the initial studies of bone metastases. The current study evaluated the safety and clinical efficacy of MRgFUS for pain palliation prior to radiation therapy, in a patient with a solitary metastatic bone lesion. This is the first case report of MRgFUS treatment with a 1-year follow-up in a patient.

MeSH Terms

Follow-Up Studies
Humans
Magnetics
Magnets
Neoplasm Metastasis
Stress, Psychological

Figure

• 

  Fig. 1 Axial CT images of the targeted bone metastatic lesion in the left scapula (circles) before treatment (left) and at 3 months after MRgFUS treatment (right). Compared with the image before MRgFUS treatment, the targeted lesion showed a more sclerotic pattern on follow-up CT images. Note.-MRgFUS = Magnetic Resonance-guided Focused Ultrasound Surgery

• 

  Fig. 2 An example of sonication during treatment. The left image shows the T2-weighted MR image of sonication to the left scapula for treatment planning. The right MR image shows the thermal map following sonication. The central image shows the calculated temperature elevation during this sonication, which reached a maximum of 69℃.

• 

  Fig. 3 Treatment outcome - Left: Axial T1 with Fat Sat and with contrast MR image of the targeted bone metastatic lesion in the left scapula prior to MRgFUS treatment. Right: Axial T1 with Fat Sat and with contrast MR image of the targeted bone metastatic lesion in the left scapula immediately after MRgFUS treatment, showing non-perfusion in the soft tissue surrounding the scapula. Left scapula is marked with a circle. Note.-MRgFUS = Magnetic Resonance-guided Focused Ultrasound Surgery

• 

  Fig. 4 A graph showing the average Visual Analog Scale (VAS) of pain in the left scapula as reported by the patient, before and after MRgFUS treatment. Note.-MRgFUS = Magnetic Resonance-guided Focused Ultrasound Surgery

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