J Korean Assoc Maxillofac Plast Reconstr Surg.
2012 Sep;34(5):299-310.
Restoration of Calvarial Defect Using a Variety of Xenogenous Tooth Bone Graft Material: Animal Study
- Affiliations
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- 1Department of Oral and Maxillofacial Surgery, Section of Dentistry, Seoul National Univerity Bundang Hospital, Korea. pilyoung@snubh.org
- 2Preclinical Research Center, Biomedical Research Institute, Seoul National Univerity Bundang Hospital, Korea.
- 3Korea Tooth Bank, R&D Institute, Korea.
- 4Department of Pathology, College of Medicine, Soon Chun Hyang University, Korea.
Abstract
- PURPOSE
The purpose of this study was to evaluate the histological healing process of 3 different types of xenogenic tooth bone graft material and xenogenic bone graft material.
METHODS
Three types of human tooth bone graft material (chips, crowns, and roots) and BioOss (Geistlich Pharma AG, Wolhausen, Switzerland) was filled at the preformed 4 round-shaped calvarial bone defects of beagle dogs. The beagles were sacrificed at 2, 4, 8, and 12 weeks, respectively, for radiological and histological evaluation.
RESULTS
Increased strength and radiopacity were detected in all graft material groups in time-dependent manner. New bone was formed and matured surrounding the graft material histologically. Also, a new bone was directly integrated with graft material.
CONCLUSION
It was expected that newly developed tooth bone graft material would show good bone healing capacity if it was used as a graft material for the restoration of bony defect.
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