J Korean Assoc Oral Maxillofac Surg.  2012 Feb;38(1):2-8. 10.5125/jkaoms.2012.38.1.2.

Clinical application of auto-tooth bone graft material

Affiliations
  • 1Department of Oral and Maxillofacial Surgery, College of Dentistry, Dankook University, Cheonan, Korea. kkwoms@dku.edu
  • 2Chief Technology Officer, R&D Director, Korea Tooth Bank, Seoul, Korea.
  • 3Seoul National University Bundang Hospital, Seongnam, Korea.

Abstract

INTRODUCTION
Auto-tooth bone graft material consists of 55% inorganic hydroxyapatite (HA) and 45% organic substances. Inorganic HA possesses properties of bone in terms of the combining and dissociating of calcium and phosphate. The organic substances include bone morphogenetic protein and proteins which have osteoinduction capacity, as well as the type I collagen identical to that found in alveolar bone. Auto-tooth bone graft material is useful as it supports excellent bone regeneration capacity and minimizes the possibility of foreign body reaction,genetic diseases and disease transmission.
MATERIALS AND METHODS
Implant placement combined with osteoinductive regeneration,preservation of extraction socket, maxillary sinus augmentation, and ridge augmentation using block type,powder type, and block+powder type autobone graft materialwere performed for 250 patients with alveolar bone defect and who visited the Department of Oral and Maxillofacial Surgery, College of Dentistry, Dankook University from September 2009 to August 2011.
RESULTS
Clinical assessment: Among the 250 patients of auto-tooth bone graft, clinical assessment was performed for 133 cases of implant placement. The average initial stabilization of placed implants was 74 implant stability quotient (ISQ). Radiological assessment: The average loss of crestal bone in the mandible as measured 6 months on the average after the application of prosthesis load was 0.29 mm, ranging from 0 mm to 3.0 mm. Histological assessment: In the histological assessment, formation of new bone, densified lamellated bone, trabecular bones, osteoblast, and planting fixtures were investigated.
CONCLUSION
Based on these results, we concluded that auto-tooth bone graft material should be researched further as a good bone graft material with osteoconduction and osteoinduction capacities to replace autogenous bone, which has many limitations.

Keyword

Auto-tooth bone; Osteoconduction; Osteoinduction

MeSH Terms

Bone Morphogenetic Proteins
Bone Regeneration
Calcium
Collagen Type I
Dentistry
Durapatite
Foreign Bodies
Humans
Mandible
Maxillary Sinus
Osteoblasts
Plants
Prostheses and Implants
Proteins
Surgery, Oral
Transplants
Bone Morphogenetic Proteins
Calcium
Collagen Type I
Durapatite
Proteins

Figure

  • Fig. 1 Block type.

  • Fig. 2 Powder type.

  • Fig. 3 Clinical application of auto-tooth bone (total: 250 cases).

  • Fig. 4 Types of auto-tooth bone material and surgery. (GBR: guided bony regeneration)

  • Fig. 5 Type of complication.

  • Fig. 6 After 6 months, computed tomography (CT) scan around buccal wall defect (arrow) showed more radio-opacity than the initial implantation with auto-tooth bone grafting. A. Initial CT view. B. CT view after 6 months.

  • Fig. 7 Resorbing enamel (yellow arrows) and dentin (blue arrows) were noted. Some enamel stayed independent (orange arrows) without surrounding bone in subject group patient I. A. Optical microscopic view (H&E stanining, ×40). B. Polarizing microscopic view (H&E staining, ×40). C, D. Optical microscopic view (H&E staining, ×100).


Cited by  3 articles

Collagen biology for bone regenerative surgery
Masaru Murata
J Korean Assoc Oral Maxillofac Surg. 2012;38(6):321-325.    doi: 10.5125/jkaoms.2012.38.6.321.

Bone graft material using teeth
Young-Kyun Kim
J Korean Assoc Oral Maxillofac Surg. 2012;38(3):134-138.    doi: 10.5125/jkaoms.2012.38.3.134.

Tooth-derived bone graft material
Young-Kyun Kim, Junho Lee, In-Woong Um, Kyung-Wook Kim, Masaru Murata, Toshiyuki Akazawa, Masaharu Mitsugi
J Korean Assoc Oral Maxillofac Surg. 2013;39(3):103-111.    doi: 10.5125/jkaoms.2013.39.3.103.


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