Nucl Med Mol Imaging.
2012 Mar;46(1):41-47.
Retrocrural Lymph Node Metastasis Disclosed by 18F-FDG PET/CT: A Predictor of Supra-diaphragmatic Spread in Ovarian Cancer
- Affiliations
-
- 1Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea.
- 2Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea. jkchung@snu.ac.kr
- 3Institute of Radiation Medicine, Seoul National University College of Medicine, Seoul, Korea.
- 4Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea.
- 5Department of Molecular Medicine and Biopharmaceutical Sciences, WCU Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Korea.
Abstract
- PURPOSE
Retrocrural lymph nodes (RCLNs) communicate with retroperitoneal and posterior mediastinal LNs. It is possible that, when RCLNs are involved, supra-diaphragmatic extension will occur in abdomino-pelvic cancers. The authors investigated performance of 18F-FDG PET/CT to diagnose RCLN metastasis and whether RCLN metastases were associated with supra-diaphragmatic lymphatic metastases of ovarian cancer.
MATERIALS AND METHODS
Sixty-seven patients with stage IV ovarian cancer who had undergone 18F-FDG PET/CT were included in this retrospective study. Diagnostic performance of 18F-FDG PET/CT for RCLN metastasis was evaluated. Patients were divided into two groups by presence or absence of supra-diaphragmatic LN metastasis. The prevalences of RCLN metastasis between the two groups were compared and the odds ratio was calculated.
RESULTS
Sensitivity and specificity of 18F-FDG PET/CT for RCLN metastasis were 96.3 and 100%, respectively. Of the 67 study subjects, 27 patients had RCLN metastases (40.3%). Fifty patients had supra-diaphragmatic LN metastases. 18F-FDG PET/CT showed 26 RCLN metastases in patients with supra-diaphragmatic LN metastases (54.5%), and only 1 in patients without supra-diaphragmatic LN metastasis (5.9%), and the difference between two groups was statistically significant (P<0.05). The odds ratio that patients with RCLN metastasis would have supra-diaphragmatic LN metastasis was 17.3 (95% confidence interval=2.1 to 140.9, P=0.008).
CONCLUSION
Performance of 18F-FDG PET/CT to diagnose RCLN metastasis was excellent. RCLN metastasis revealed by 18F-FDG PET/CT was strongly associated with supradiaphragmatic LN spread of ovarian cancer. Thus, RCLN metastasis could be used as a predictor of supra-diaphragmatic lymphatic metastasis of ovarian cancer.
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