J Korean Assoc Pediatr Surg.  2013 Jun;19(1):25-31. 10.13029/jkaps.2013.19.1.25.

Extragonadal Intraabdominal Mixed Germ Cell Tumor with Liver Metastasis: Successful Treatment and Long-term Follow-up

• Park J

• KMID: 1427982
• DOI: http://doi.org/10.13029/jkaps.2013.19.1.25

Abstract

No abstract available.

Keyword

Extragonadal germ cell tumors; Endodermal sinus tumor; Mature teratoma; Girl

MeSH Terms

Endodermal Sinus Tumor
Follow-Up Studies
Germ Cells
Liver
Neoplasms, Germ Cell and Embryonal

Figure

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  Fig. 1 Abdominal CT scan in our patient, showing a 12 × 8 cm, well-demarcated, cystic mass with calcification and solid and fat components in the left upper quadrant of the abdomen.

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  Fig. 2 Gross appearance of the resected tumor. The tumor appears as a whitish to gray globular solid mass, measuring 10 × 9 cm. The cut surface shows semisolid grayish material and cartilaginous tissue.

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  Fig. 3 Microscopic examination, showing that the primary tumor was composed primarily of endodermal sinus tumor components. A loose reticular pattern and rounded papillary processes with central capillary, "Schiller-Duval bodies" were also observed (arrow). The section from the liver shows a metastatic germ cell tumor, composed primarily of an endodermal sinus tumor component (H & E, × 200 magnification).

Reference

1. Theegarten D, Reinacher A, Graeven U, Philippou S. Mixed malignant germ cell tumour of the liver. Virchows Arch. 1998; 433:93–96.

2. Billmire D, Vinocur C, Rescorla F, Colombani P, London W, Giller R, Cushing B, Lauer S, Cullen J, Davis M, Hawkins E. Malignant retroperitoneal and abdominal germ cell tumors: an intergroup study. J Pediatr Surg. 2003; 38:315–318.

3. Verma M, Agarwal S, Mohta A. Primary mixed germ cell tumour of the liver--a case report. Indian J Pathol Microbiol. 2003; 46:658–659.

4. Lack EE, Travis WD, Welch KJ. Retroperitoneal germ cell tumors in childhood. A clinical and pathologic study of 11 cases. Cancer. 1985; 56:602–608.

5. Jones MA, Clement PB, Young RH. Primary yolk sac tumors of the mesentery. A report of two cases. Am J Clin Pathol. 1994; 101:42–47.

6. Xu AM, Gong SJ, Song WH, Li XW, Pan CH, Zhu JJ, Wu MC. Primary mixed germ cell tumor of the liver with sarcomatous components. World J Gastroenterol. 2010; 16:652–656.

7. Tangour-Bouaicha M, Bel Haj Salah M, Ben Brahim E, Ben Othmène M, Douggaz A, Sassi S, Chatti-Dey S. Primary peritoneal yolk sac tumour. A case report. Ann Pathol. 2010; 30:378–381.

8. Xinghui Y, Jing H, Mingju L, Weizhong G. Endodermal sinus tumour of the omentum in a child. Pediatr Radiol. 2004; 34:985–987.

9. Kim SW, Park JH, Lim MC, Park JY, Yoo CW, Park SY. Primary yolk sac tumor of the omentum: a case report and review of the literature. Arch Gynecol Obstet. 2008; 279:189–192.

10. Park NH, Ryu SY, Park IA, Kang SB, Lee HP. Primary endodermal sinus tumor of the omentum. Gynecol Oncol. 1999; 72:427–430.