Korean J Ophthalmol.  2012 Oct;26(5):388-390. 10.3341/kjo.2012.26.5.388.

A Case of Cystoid Macular Edema Associated with Paclitaxel Chemotherapy

• Ham DS
• Lee JE
• Kim HW
• Yun IH

• KMID: 1397491
• DOI: http://doi.org/10.3341/kjo.2012.26.5.388

Abstract

We encountered a patient with cystoid macular edema (CME) secondary to paclitaxel use. A 57-year-old man presented with gradual decreased bilateral vision. His chemotherapeutic regimen consisted of bevacizumab, paclitaxel (175 mg/m2 for 5 months), and carboplatin. Optical coherence tomography imaging revealed bilateral CME greater than 500 microm. However, one year later, visual acuity was improved, best-corrected Snellen visual acuity was 40 / 80 in each eye, and CME was spontaneously improved. Our study confirmed that macular edema associated with paclitaxel use shows spontaneous resolution and improvement of visual acuity after a change of chemotherapeutic regimen.

Keyword

Macular edema; Paclitaxel

MeSH Terms

Adenocarcinoma/drug therapy
Antineoplastic Agents, Phytogenic/*adverse effects
Antineoplastic Combined Chemotherapy Protocols/therapeutic use
Humans
Lung Neoplasms/drug therapy
Macular Edema/*chemically induced
Male
Middle Aged
Paclitaxel/*adverse effects
Remission, Spontaneous
Tomography, Optical Coherence
Visual Acuity

Figure

• 

  Fig. 1 (A-D) The right eye of the patient. (A) Before intravitreal bevacizumab plus triamcinolone injection, fundus showed cystic change of the macula. (B) Fluorescein angiograms (FA) showed hyperfluorescence in the macula in the late frame. (C) Optical coherence tomography (OCT) showed cystoid macular edema (CME). (D) Six weeks after the injection, CME was unchanged in OCT. (E-H) The left eye of the patient. (E) Before intravitreal bevacizumab plus triamcinolone injection, fundus showed cystic change of the macula. (F) FA showed hyperfluorescence in the macula in the late frame. (G) OCT showed CME. (H) Six weeks after the injection, CME was unchanged in OCT.

• 

  Fig. 2 The right (A) and left (B) eyes of the patient. One year later, optical coherence tomography showed cystoid macular edema improved. The central retinal thickness was decreased from 502 µm to 246 µm in the right eye and from 513 µm to 228 µm in the left eye.

Reference

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