Korean J Hepatol.  2009 Dec;15(4):510-516. 10.3350/kjhep.2009.15.4.510.

A case of primary hepatic epithelioid hemangioendothelioma with spontaneous rupture

• Kim GH
• Kim YS
• Kim HO
• Kim KH
• Hung YK
• Jung DH
• Kim JH
• Kwon OS
• Choi DJ
• Kim JH

• KMID: 1384059
• DOI: http://doi.org/10.3350/kjhep.2009.15.4.510

Abstract

Primary hepatic epithelioid hemangioendothelioma is a rare neoplasm of endothelial origin. The clinical manifestations are nonspecific, ranging from complete absence of symptoms to hepatic failure and death. Spontaneous rupture of a hepatic epithelioid hemangioendothelioma is an extremely rare presentation. We present a case of primary hepatic epithelioid hemangioendothelioma in a 65-year-old male patient with alcoholic liver cirrhosis. He was hospitalized due to epigastric pain and multiple liver masses on abdominal ultrasound. Dynamic liver CT imaging revealed multiple peripheral nodular enhanced mass lesions with delayed centripetal enhancement, and the adjacent collection of high-attenuation fluid along the liver capsule. Abdominal tapping revealed blood in the peritoneal cavity. Primary hepatic epithelioid hemangioendothelioma with spontaneous rupture was finally diagnosed based on a histopathologic examination revealing positive immunohistochemical staining for CD34.

Keyword

Hepatic epithelioid hemangioendothelioma; Spontaneous rupture

MeSH Terms

Antigens, CD34/metabolism
Bone Neoplasms/diagnosis/secondary
Diagnosis, Differential
Hemangioendothelioma, Epithelioid/*diagnosis/pathology/ultrasonography
Humans
Liver Cirrhosis, Alcoholic/complications/diagnosis
Liver Neoplasms/*diagnosis/pathology/ultrasonography
Male
Pancreatic Neoplasms/diagnosis/secondary
Rupture, Spontaneous
Tomography, X-Ray Computed