J Korean Acad Nurs.  2012 Apr;42(2):207-216. 10.4040/jkan.2012.42.2.207.

Depression and Risk Factors in Patients with Crohn's Disease

Affiliations
  • 1College of Nursing, Jeju National University, Jeju, Korea.
  • 2College of Nursing, The Catholic University of Korea, Seoul, Korea. ysyoo@catholic.ac.kr
  • 3Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.

Abstract

PURPOSE
This study was conducted to determine the risk factors among patients with depression with Crohn's disease.
METHODS
Data were collected by questionnaire from 276 patients who were diagnosed with Crohn's disease at a tertiary hospital located in Seoul. Measurements included patients' demographic characteristics, clinical characteristics, depression level, and health-related quality of life. Data were analyzed using t-test, chi2-test, Wilcoxon rank sum test, and logistic regression analyses.
RESULTS
The incidence rate of depression (BDI-II> or =14scores) was 31.9% (n=88). Univariate analysis revealed that being a woman, school graduation status, economic status (low), BMI(<18.5Kg/m2), disease duration (> or =3 years), CDAI (> or =150 scores), frequency of hospital admission (> or =2), extra-intestinal manifestation (arthralgia, stomatitis), administration of 5-aminosalicylic acid, and disease related quality of life (SIBDQ<50 scores) were associated with depression. Multivariate analysis revealed that economic status (low), school graduation status, and quality of life (SIBDQ<50 scores) were more likely to report high level of depression.
CONCLUSION
Future research should consider managing depression as an essential component of comprehensive care for patients with Crohn's disease. In addition, further research is needed to develop strategies to better improve quality of life among patients with Crohn's disease who are depressed.

Keyword

Crohn's disease; Depression; Risk factors

MeSH Terms

Adult
Arthralgia/etiology
Body Mass Index
Crohn Disease/complications/drug therapy/*psychology
*Depression
Female
Humans
Logistic Models
Male
Mesalamine/therapeutic use
Quality of Life
Questionnaires
Risk Factors
Socioeconomic Factors
Stomatitis/etiology
Young Adult

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