J Korean Med Sci.  2012 May;27(5):532-536. 10.3346/jkms.2012.27.5.532.

Longitudinal Study on Trace Mineral Compositions (Selenium, Zinc, Copper, Manganese) in Korean Human Preterm Milk

• Kim SY
• Park JH
• Kim EA
• Lee-Kim YC

• KMID: 1372796
• DOI: http://doi.org/10.3346/jkms.2012.27.5.532

Abstract

We measured selenium, zinc, copper and manganese concentrations in the human milk of Korean mothers who gave birth to preterm infants, and compared these measurements with the recommended daily intakes. The samples of human milk were collected postpartum at week-1, -2, -4, -6, -8, and -12, from 67 mothers who gave birth to preterm infants (< 34 weeks, or birth weight < 1.8 kg). All samples were analyzed using atomic absorption spectrophotometry. The concentrations of selenium were 11.8 +/- 0.5, 11.4 +/- 0.8, 12.7 +/- 0.9, 11.4 +/- 0.8, 10.8 +/- 0.9, and 10.5 +/- 1.3 microg/L, zinc were 7.8 +/- 0.5, 9.1 +/- 0.8, 7.2 +/- 0.9, 8.0 +/- 0.8, 7.4 +/- 0.9, and 6.6 +/- 1.2 mg/L, copper were 506 +/- 23.6, 489 +/- 29.4, 384 +/- 33.6, 356 +/- 32.9, 303 +/- 35.0, and 301 +/- 48.0 microg/L and manganese were 133 +/- 4.0, 127 +/- 6.0, 125 +/- 6.0, 123 +/- 6.0, 127 +/- 6.0, and 108 +/- 9.0 microg/L at week-1, -2, -4, -6, -8, and -12, respectively. The concentrations of selenium and zinc meet the daily requirements but that of copper is low and of manganese exceeds daily requirements recommended by the American Academy of Pediatrics, Committee on Nutrition.

Keyword

Preterm; Milk, Human; Selenium; Zinc; Copper; Manganese

MeSH Terms

Adult
Copper/analysis
Female
Humans
Infant, Newborn
Infant, Premature
Longitudinal Studies
Manganese/analysis
Milk, Human/*chemistry
Postpartum Period
Republic of Korea
Selenium/analysis
*Spectrophotometry, Atomic
Trace Elements/*analysis
Zinc/analysis

Figure

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  Fig. 1 Amount of selenium in human preterm milk at different stages of lactation. *Recommendation by American Academy of Pediatrics, Committee on Nutrition (CON/AAP, 2009): 0.9-4.1 µg/100 kcal.

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  Fig. 2 Amount of zinc in human preterm milk at different stages of lactation. *Recommendation by American Academy of Pediatrics, Committee on Nutrition (CON/AAP, 2009): 340-2,700 µg/100 kcal.

• 

  Fig. 3 Amount of copper in human preterm milk at different stages of lactation. *Recommendation by American Academy of Pediatrics, Committee on Nutrition (CON/AAP, 2009): 80-136 µg/100 kcal.

• 

  Fig. 4 Amount of manganese in preterm human milk at different stages of lactation. *Recommendation by American Academy of Pediatrics, Committee on Nutrition (CON/AAP, 2009): 0.5-6.8 µg/100 kcal.

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