Korean J Pathol.  2012 Jun;46(3):302-305. 10.4132/KoreanJPathol.2012.46.3.302.

Cytologic Findings of Thyroid Carcinoma Showing Thymus-like Differentiation: A Case Report

• Chang S
• Joo M
• Kim H

• KMID: 1246267
• DOI: http://doi.org/10.4132/KoreanJPathol.2012.46.3.302

Abstract

Carcinoma showing thymus-like differentiation (CASTLE) is a rare carcinoma of the thyroid or adjacent soft tissue of the neck with a histologic resemblance to thymic epithelial tumors. Although the fine-needle aspiration (FNA) plays a central role in the initial evaluation of thyroid nodules, few reports about the cytologic findings of CASTLE have been found according to a review of literatures. We report cytologic findings of a case of CASTLE. A 34-year-old woman presented with a 2-month history of sore throat. The FNA showed that the smear was composed of three dimensional clusters and sheets. The tumor cells were round to ovoid with high nuclear : cytoplasmic ratios. The nuclei were vesicular with small nucleoli. There were some tumor cells showing keratinization. Some lymphocytes were found on the background and within clusters. The presence of poorly-differentiated tumor cells with a focal keratinization and a lymphocytic background on the FNA is suggestive of CASTLE.

Keyword

Thymoma; Thymus gland; Thyroid gland; Biopsy, fine-needle; Cytodiagnosis

MeSH Terms

Female
Humans