Korean J Gastroenterol.  2003 Jan;41(1):1-8.

Eradication Rate of Helicobacter pylori According to the Diseases and Therapeutic Regimens, and Reinfection Rate after Successful Eradication in a Tertiary Clinic

• Chung WC
• Cho YS
• Jeong JJ
• Lee IS
• Kim SW
• Yang JM
• Choi MG
• Chung IS
• Park DH

Abstract

BACKGROUND/AIMS: Controversies regarding the indications and regimens for the eradication of Helicobacter pylori (H. pylori) still exist. Failure rates have been reported to range from 5% to 10%. This study aimed to review the efforts for the eradication of H. pylori in a tertiary clinic. We assessed the eradication rates according to the diseases, therapeutic regimens, and duration of therapy. In addition, we examined the effectiveness of secondary regimens in patients who failed to respond to primary regimens and the reinfection rate after a successful eradication. METHODS: We investigated 389 patients with documented H. pylori infection between January 1996 and December 2001. RESULTS: The overall eradication rate was 79.2%. There were no significant differences in the eradication rates sccording to the diseases and therapeutic regimens. However, there was a significant difference according to the duration of therapy. Proton pump inhibitor (PPI)-based 10-day and 14-day regimens were superior to 7-day regimens. The eradication rate of secondary regimens in patients who failed to respond to primary regimens was 76.9%. The reinfection rate after a successful eradication was 4.4%. CONCLUSIONS: These results suggest that PPI-based triple regimens with 10 or 14 days of duration should be considered as primary H. pylori eradication therapy.

Keyword

Helicobacter pylori; Eradication rate; Reinfection rate