J Korean Med Sci.  2001 Jun;16(3):355-359. 10.3346/jkms.2001.16.3.355.

A Case of Torsade de Pointes Associated with Hypopituitarism due to Hemorrhagic Fever with Renal Syndrome

• Kim NH
• Cho JG
• Ahn YK
• Lee SU
• Kim KH
• Cho JH
• Kim HG
• Kim W
• Jeong MH
• Park JC
• Kang JC

• KMID: 1129911
• DOI: http://doi.org/10.3346/jkms.2001.16.3.355

Abstract

We describe a 51-yr-old man presenting with syncope due to torsade de pointes. The torsade de pointes was refractory to conventional medical therapy, including infusion of isoproterenol, MgSO4, potassium, lidocaine, and amiodarone. His past history, physical findings, and hormone study confirmed that QT prolongation was caused by anterior hypopituitarism that developed as a sequela of hemorrhagic fever with renal syndrome. The long QT interval with deep inverted T wave was completely normalized 4 weeks after starting steroid and thyroid hormone replacement. Hormonal disorders should be considered as a cause of torsade de pointes, because this life-threatening arrhythmia can be treated by replacing the missing hormone.

Keyword

Torsades de Pointes; Hypopituitarism; Hemorrhagic Fever with Renal Syndrome

MeSH Terms

Hemorrhagic Fever with Renal Syndrome/*complications/physiopathology
Hormone Replacement Therapy
Human
Hypopituitarism/drug therapy/*etiology/physiopathology
Male
Middle Age
Tachycardia, Ventricular
Torsades de Pointes/drug therapy/*etiology/physiopathology