J Korean Med Sci.  2000 Jun;15(3):346-350. 10.3346/jkms.2000.15.3.346.

Eosinophilic fasciitis preceding relapse of peripheral T-cell lymphoma

• Kim H
• Kim MO
• Ahn MJ
• Lee YY
• Jung TJ
• Choi IY
• Kim IS
• Park CK

• KMID: 1128636
• DOI: http://doi.org/10.3346/jkms.2000.15.3.346

Abstract

Although eosinophilic fasciitis (EF) may precede hematologic malignancy or Hodgkin's disease, association with peripheral T-cell lymphoma (PTCL) is extremely rare. Only four cases of EF preceding or concomitant PTCL have been reported in the world literature. We experienced the first Korean case of EF complicated by the later relapse of peripheral T-cell lymphoma. A 63-year-old Korean male has been followed at our outpatient clinic periodically after treatment for stage IV PTCL. He had been in complete remission for seven and a half years when he developed edema of both lower extremities followed by sclerodermatous skin change in both hands with peripheral eosinophilia. Biopsy from the left hand showed fibrous thickening of the fascia with lymphoplasmacytic and eosinophilic infiltrate, consistent with EF. Twenty-five months later, a newly developed lymph node from the left neck showed recurrence of PTCL. EF may occur as a paraneoplastic syndrome associated with the relapse of PTCL. Therefore, in a patient with EF, the possibility of coexisting and/or future occurrence of hematologic neoplasm should be considered.

Keyword

Eosinophilic Fasciitis; Lymphoma, T-Cell, Peripheral; Paraneoplastic Syndromes

MeSH Terms

Case Report
Eosinophilia/pathology
Eosinophilia/complications*
Fasciitis/pathology
Fasciitis/complications*
Human
Lymphoma, T-Cell, Peripheral/pathology
Lymphoma, T-Cell, Peripheral/complications*
Male
Middle Age
Recurrence