J Korean Med Sci.  1996 Aug;11(4):356-357. 10.3346/jkms.1996.11.4.356.

Localized periorbital edema as a clinical manifestation of sulfite sensitivity

• Park HS
• Nahm D

• KMID: 1123822
• DOI: http://doi.org/10.3346/jkms.1996.11.4.356

Abstract

Sulfite is commonly used in pharmaceuticals as a preservative. We report a unique clinical presentation of localized periorbital edema on the left eye after administration of sulfite-containing dexamethasone. The patient's sulfite sensitivity was confirmed by sulfite oral provocation test: periorbital edema on the same site developed after ingestion of 200 mg sodium bisulfite. She was non-atopic and did not complain of any respiratory symptoms. Allergy skin prick test with 100 mg/ml sodium bisulfite showed a negative result. She also has aspirin-sensitive urticaria which was confirmed by oral provocation test. In conclusion, sulfite can induce a localized periorbital edema, an uncommon manifestation in sensitive patients. Further investigations are needed to clarify the pathogenetic mechanisms.

Keyword

Perioibital edema; Sulfite-sensitivity

MeSH Terms

Allergens/*therapeutic use
Case Report
Edema/*etiology
Female
Human
Middle Age
Orbital Diseases/*etiology
Skin Diseases/drug therapy
Sulfites/*therapeutic use