J Vet Sci.
2004 Jun;5(2):173-180.
Canine biphasic synovial sarcoma: case report and immunohistochemical characterization
- Affiliations
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- 1Division of Veterinary Pathology and Anatomy, School of Veterinary Science, The University of Queensland, St. Lucia 4072, Australia.
- 2Faculty of Veterinary Medicine, Universiti Putra Malaysia, 43400 Serdang, Selangor Darul Ehsan, Malaysia.
- 3Pathology Division, National Cancer Center Research Institute, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. ploukopo@gan2.res.ncc.go.jp
- 4Department of Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, USA.
- 5Department of Veterinary Clinical Sciences, Royal Veterinary College, Hawkshead Lane, North Mymms, Hatfield AL9 7TA, United Kingdom.
Abstract
- The clinical, radiological and pathologic features of a biphasic synovial sarcoma in the left elbow joint of a two-year-old male Rottweiler are presented. The tumor showed positive immunoreactivity for vimentin, Epithelial Membrane Antigen (EMA), p53 and PCNA, while it was negative for the cytokeratin used, S-100, Rb and p21. Immunohistochemistry for EMA allowed the identification of epithelioid components of synovial sarcoma, and may, therefore, contribute in establishing a diagnosis of biphasic synovial sarcoma. Intratumoral variation in PCNA immunoreactivity was minimal, indicating that the various tumor components proliferate at more or less similar rates. Overall, the characterized immunohistochemical profile for canine synovial sarcoma, not defined previously, may provide clues to the histogenesis of the phenotypically mesenchymal and epithelial elements of the tumor, and may be of value in the differential diagnosis of challenging cases, decreasing the risk of under- and mis-diagnosis. Although more cases need to be studied to determine whether there is a consistent pattern of immunostaining in canine synovial sarcoma, its potential significance is discussed in relation to the histogenesis, molecular pathology and differential diagnosis of canine synovial sarcoma.
Keyword
MeSH Terms
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Animals
CA-15-3 Antigen/analysis
Dog Diseases/*pathology/radiography
Dogs
Elbow Joint/abnormalities/pathology/radiography
Forelimb
Histocytochemistry/veterinary
Immunohistochemistry/veterinary
Keratins/analysis
Male
Oncogene Protein p21(ras)/analysis
Proliferating Cell Nuclear Antigen/analysis
Retinoblastoma Protein/analysis
Sarcoma, Synovial/chemistry/pathology/radiography/*veterinary
Soft Tissue Neoplasms/chemistry/radiography/*veterinary
Tumor Suppressor Protein p53/analysis
Vimentin/analysis
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