J Vet Sci.  2005 Jun;6(2):135-139.

Serum interferon-gamma and interleukins-6 and -8 during infection with Fasciola gigantica in cattle and buffaloes

• Molina EC

Abstract

This study investigated the presence of cytokines interferon (IFN)-gamma, interleukins (IL) -6 and -8 in serum of cattle and buffaloes infected with Fasciola gigantica from one to 16 weeks post-infection to determine their T cell response during infection. The concentration of these cytokines was determined by sandwich enzyme-linked immunosorbent assay (ELISA). No IFN-gamma was detected in these animals while IL-6 was elevated from one to 16 weeks postinfection. Levels of IL-8 were also elevated in infected buffaloes from one to 16 weeks post-infection. A predominantly T helper (Th) 2 response which started early in the infection was apparently present in cattle and buffaloes in this study which was characterised by IL-6. IL-8 production could be another mechanism of immune response in buffaloes during infection with F. gigantica.

Keyword

buffaloes; cattle; cytokines; Fasciola gigantica

MeSH Terms

Animals
Buffaloes/blood/immunology/*parasitology
Cattle
Cattle Diseases/*immunology/*parasitology
Cytokines/*blood/immunology
Enzyme-Linked Immunosorbent Assay/veterinary
Fasciola/*immunology
Fascioliasis/immunology/parasitology/*veterinary
Interferon Type II/blood
Interleukin-6/blood
Interleukin-8/blood
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