Korean J Ophthalmol.  2011 Apr;25(2):146-150. 10.3341/kjo.2011.25.2.146.

A Case of Optic Nerve Atrophy with Severe Disc Cupping after Methanol Poisoning

• Shin YW
• Uhm KB

• KMID: 1111880
• DOI: http://doi.org/10.3341/kjo.2011.25.2.146

Abstract

We report a rare case of optic nerve atrophy with severe disc cupping resulting from methanol poisoning. A 30-year-old man presented to the hospital complaining of decreased visual acuity in both eyes a day after drinking alcohol containing methanol. His initial visual acuity allowed for only visualizing hand motion and not corrected in either eye. Initial intraocular pressure was within normal limits in both eyes. Initial fundus examination showed optic disc swelling in both eyes. Four years later, he visited our hospital for an eye evaluation. Visual acuity in both eyes still only allowed for visualizing hand motion. No nystagmus was observed in either eye during the optokinetic nystagmus test, and no waves were found in a visual evoked potential test. No specific change was noted on brain magnetic resonance imaging. On fundus examination, there was disc pallor in both eyes and disc cupping with a high cup/disc (C/D) ratio above 0.9 in the left eye. C/D ratio of the right eye was 0.5. Methanol poisoning may induce glaucomatous disc cupping in the late stage as well as optic atrophy. One possible mechanism of disc cupping is ganglion cell loss due to acute demyelination of the retrobulbar optic nerve. This report is the first photographic evidence of methanol induced optic disc cupping in Korea.

Keyword

Disc cupping; Methanol; Optic atrophy

MeSH Terms

Adult
Diagnosis, Differential
Evoked Potentials, Visual
Fluorescein Angiography
Fundus Oculi
Humans
Magnetic Resonance Imaging
Male
Methanol/*poisoning
Optic Atrophy/*chemically induced/pathology/physiopathology
Optic Disk/drug effects/*pathology
Papilledema/*chemically induced/pathology/physiopathology
Severity of Illness Index
Solvents/poisoning
Tomography, Optical Coherence
Visual Acuity

Figure

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  Fig. 1 A 30-year-old man complained of visual disturbance in both eyes one day after drinking methanol. The fundus photographs demonstrate optic disc edema with blurred disc margins at the initial visit. (A) Right eye, (B) left eye.

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  Fig. 2 The patient presented to our hospital four years after the initial visit for methanol intoxication. (A,B) Red free photographs of both eyes. Red free photographs demonstrate diffuse defects of retinal nerve fiber layers in both eyes. (C) Disc photograph of the right eye, which shows optic nerve atrophy. (D) Disc photograph of the left eye which shows severe disc cupping.

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  Fig. 3 Result of retinal nerve fiber layer (RNFL) thickness in optical coherence tomography. RNFL thinkness of both eyes is under one percentile of normal distribution in nearly all sectors. This exam was performed four years after methanol intoxicaion. TEMP=temporal; SUP=superior; NAS=nasal; INF=inferior; Imax=inferior maximum; Smax=superior maximum; Tavg=temporal average; Navg=nasal average; Max-Min = the difference value between maximum and minimum thickness; Savg=superior average; Iavg=inferior average.

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  Fig. 4 Vertical radial scans of optical coherence tomography (OCT) in both optic nerve heads. The cup area, cup/disc area and cup disc ratio of the left eye are larger than those of the right eye in OCT. This exam was performed four years after methanol intoxicaion. (A) Right eye, (B) left eye.

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  Fig. 5 Visual evoked potentials (VEP) both eyes. Note that waves of N75, P100 and N145 do not appear in either eye. This exam was performed four years after methanol intoxicaion. (A) Right eye, (B) left eye.

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