Yonsei Med J.  2011 Sep;52(5):761-767. 10.3349/ymj.2011.52.5.761.

Localized Resectable Genitourinary Sarcoma in Adult Korean Patients: Experiences at a Single Center

• Cho SY
• Moon KC
• Cheong MS
• Kwak C
• Kim HH
• Ku JH

• KMID: 1108068
• DOI: http://doi.org/10.3349/ymj.2011.52.5.761

Abstract

PURPOSE
To evaluate the clinicopathological characteristics and prognosis of localized resectable genitourinary sarcomas in adults.
MATERIALS AND METHODS
Between September, 1996 and November, 2008, 18 consecutive cases of adults (12 men and 6 women; median age 48.8 years) who were treated for primary genitourinary sarcomas were identified. The following variables were analyzed: patient age, gender, body mass index, American Society of Anesthesiologists (ASA) score, primary organ, tumor histology, size, necrosis, Federation Nationale des Centres de Lutte Contre le Cancer (FNCLCC) grade, and surgical margin positivity. Recurrence-free survival and disease-specific survival were the study end-points.
RESULTS
The most common presenting symptom was a palpable mass (six cases, 33.3%), the most common site was the kidney (six cases, 33.3%), and the most common histological subtype was leiomyosarcoma (eight patients, 44.4%). Complete resection with negative surgical margins was achieved in 13 patients (72.2%). The median follow-up period was 49.9 months (range 6.4 to 147.6). The recurrence-free survival rates at 1, 3, and 5 years were 81.6%, 66.5%, and 66.5%, respectively. Recurrence-free survival only associated significantly with ASA score (p=0.018). The disease-specific survival rate at 1, 3, and 5 years was 88.9%, 76.2%, and 67.7%, respectively. Disease-specific survival was associated significantly only with FNCLCC grade (p=0.042).
CONCLUSION
Although genitourinary sarcomas in adults are a rare group of tumors with a poor prognosis, some patients may have a favorable prognosis. Our findings suggest that FNCLCC grade is the most important prognostic factor for these patients.

Keyword

Urogenital neoplasms; sarcoma; genitourinary tract; survival; prognosis

MeSH Terms

Adult
Aged
Female
Humans
Immunohistochemistry
Kaplan-Meier Estimate
Male
Middle Aged
Neoplasm Grading
Prognosis
Republic of Korea
Sarcoma/metabolism/pathology/*surgery
Urogenital Neoplasms/metabolism/pathology/*surgery
Young Adult

Figure

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  Fig. 1 (A) Kaplan-Meier survival analysis of the recurrence-free survival of 18 genitourinary sarcomas on the basis of the American Society of Anesthesiologists score. (B) Kaplan-Meier survival analysis of the disease-specific survival of 18 genitourinary sarcomas on the basis of the Fédération Nationale des Centres de Lutte Contre le Cancer grade. ASA, American Society of Anesthesiologists; FNCLCC, Fédération Nationale des Centres de Lutte Contre le Cancer.

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