J Korean Med Sci.  1998 Feb;13(1):49-53. 10.3346/jkms.1998.13.1.49.

Localized in vivo proton spectroscopy of renal cell carcinoma in human kidney

• Kim DY
• Kim KB
• Kim OD
• Kim JK

• KMID: 1107226
• DOI: http://doi.org/10.3346/jkms.1998.13.1.49

Abstract

In order to obtain proton magnetic resonance spectra from the renal tumor in human kidney we performed localized magnetic resonance spectroscopy using a saddle-type flexible surface coil. Five patients biopsy-proven as renal cell carcinoma at different stages were put in supine/lateral position to minimize motion artifacts while acquiring the spectrum. Water-suppressed 1H spectra were obtained with localized stimulated echo acquisition mode (STEAM) (20/13.7/2200; TE/TM/TR) and point resolved spectroscopy (PRESS) (288/2200; TE/TR) sequences. The principal resonances in the tumor STEAM spectrum were sorbitol (3.85 ppm), trimethylamines (TMA) (3.25 ppm), two unidentified signals (2.8 and 2.2 ppm), and lipid (0.9-1.8 ppm). In the PRESS spectrum using a long echo time (288 ms), two well localized signals, TMA at 3.25 ppm and lactate at 1.35 ppm were observed from a patient with a tumor at advanced stage. Interestingly only TMA at 3.25 ppm was observed from the patient with a low grade tumor. The spectral patterns of the tumor patients were different from those of normal kidney.

MeSH Terms

Adult
Aged
Carcinoma, Renal Cell/pathology
Carcinoma, Renal Cell/metabolism*
Human
Kidney Neoplasms/pathology
Kidney Neoplasms/metabolism*
Middle Age
Nuclear Magnetic Resonance, Biomolecular/methods*