Korean J Ophthalmol.  2007 Sep;21(3):142-145. 10.3341/kjo.2007.21.3.142.

Photodynamic Therapy With Verteporfin for Choroidal Neovascularization in Patients with Angioid Streaks

• Lee JM
• Nam WH
• Kim HK

• KMID: 1099028
• DOI: http://doi.org/10.3341/kjo.2007.21.3.142

Abstract

PURPOSE: To evaluate the functional and anatomic outcomes of photodynamic therapy (PDT) for choroidal neovascularization (CNV) in patients with angioid streaks. METHODS: The authors retrospectively evaluated 6 consecutive patients (6 eyes) with CNV secondary to angioid streaks. All patients were treated with standard PDT with verteporfin protocol. Standardized protocol refraction, visual acuity testing, ophthalmologic examination, color photographs, fluorescein angiograms and indocyanin angiograms were used to evaluate the results of PDT with verteporfin. Main outcome measures were visual acuity and CNV size. RESULTS: Their mean age was 61.3+/-5.50 years (range, 53-68 years). Follow-up time ranged from 12 to 38 months with mean of 20.5+/-10.91 months. The mean visual acuity at baseline was 20/100 (range 20/25-20/500), and the mean visual acuity at the last examination was 20/320(range 20/125-counting finger). The mean greatest linear dimension (GLD) at baseline was 2400+/-766.81 micrometer, and the mean GLD at the last examination was 3483+/-444.59 micrometer. CONCLUSIONS: PDT for CNV associated with angioid streaks seemed to slow down but not prevent the progression of the disease and associated visual loss.

Keyword

Angioid streak; Photodynamic therapy; Subfoveal choroidal neovascularization

MeSH Terms

Aged
Angioid Streaks/*complications/*drug therapy
Choroidal Neovascularization/*complications/*drug therapy
Female
Humans
Male
Middle Aged
*Photochemotherapy
Photosensitizing Agents/*therapeutic use
Porphyrins/*therapeutic use
Retrospective Studies

Figure

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  Fig. 1 Case 5 : Pretreatment fundus photography (A) and fluorescein angiogram (B) reveals subfoveal choroidal neovascular membrane associated with hemorrhage. Posttreatment fundus photography (C) and fluorescein angiogram (D) at 9 months reveal marked enlargement, increased leakage, and disciform conversion of the neovascular complex

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