Korean J Parasitol.  2008 Jun;46(2):71-75. 10.3347/kjp.2008.46.2.71.

Antibody Responses to Cryptosporidium Antigen in HIV-positive Patients in the Republic of Korea

• Guk SM
• Chai JY
• Shin YO
• Seo M

• KMID: 1089465
• DOI: http://doi.org/10.3347/kjp.2008.46.2.71

Abstract

The diagnosis of cryptosporidiosis has been carried out using coprologic techniques in the Republic of Korea. However, antibody responses to Cryptosporidium have rarely been studied. Serum antibodies from HIV-positive/oocyst-positive Korean patients recognized significantly 31 and 27 kDa antigens, and HIV-negative/oocyst-positive individuals clearly reacted to 15/17 kDa antigens. Compared with oocyst-positive cases, 18.7% and 75.8% of sera from HIV-positive patients reacted to 31 and 27 kDa antigens. Only 11.1% of HIV-negative individuals reacted to 15/17 kDa. Based on these findings, serum antibody responses were different between HIV-positive and HIV-negative individuals infected with Cryptosporidium, and it is suggested that HIV-positive patients are more frequently exposed to C. parvum compared to HIV-negative individuals.

Keyword

Cryptosporidium parvum; serologic response; antigenic protein; HIV

MeSH Terms

AIDS-Related Opportunistic Infections/blood/*immunology
Adult
Aged
Animals
Antibodies, Protozoan/*blood/immunology
*Antibody Formation
Antigens, Protozoan/chemistry/*immunology
Blotting, Western/methods
Cryptosporidiosis/blood/*immunology
Feces/parasitology
Female
Humans
Korea
Male
Middle Aged
Protozoan Proteins/chemistry/immunology