Yonsei Med J.  2008 Apr;49(2):265-271. 10.3349/ymj.2008.49.2.265.

Outcome Following Surgical Closure of Patent Ductus Arteriosus in Very Low Birth Weight Infants in Neonatal Intensive Care Unit

• Lee GY
• Sohn YB
• Kim MJ
• Jeon GW
• Shim JW
• Chang YS
• Huh J
• Kang IS
• Yang JH
• Jun TG
• Park PW
• Park WS
• Lee HJ

• KMID: 1084500
• DOI: http://doi.org/10.3349/ymj.2008.49.2.265

Abstract

PURPOSE
The aims of this study were to determine the factors affecting the outcome of patent ductus arteriosus ligation in very low birth weight infants (VLBWI) and demonstrate the safety of PDA ligation in VLBWI performed in the neonatal intensive care unit (NICU). MATERIALS AND METHODS: From October 1994 to July 2006, medical records of 94 VLBWI weighing < 1,500g who underwent PDA ligation in the NICU of Samsung Medical Center were reviewed retrospectively. Factors affecting the final outcome of PDA ligation were evaluated by dividing the infants into 3 groups according to mortality and major morbidities as follows: mortality group (Mo), major morbidity group (Mb), and no major morbidity group (NM). RESULTS: In the Mo group, birth weight was significantly lower and the preoperative mean FiO(2) and mean dopamine dose were significantly higher than those in the other 2 groups. There was no significant difference in gestational age, incidence of RDS, number of courses of indomethacin, surgery-related factors, including weight and age at surgery, perioperative vital signs, and complications after surgery between the 3 groups. During surgery in the NICU, there were no significant hemodynamic instability or serious acute complications. CONCLUSION: The factors affecting the outcome of surgery in VLBWI are not the factors related to surgery but the preoperative conditions related to the underlying prematurity. PDA ligation of VLBWI performed in the NICU is safe without serious complications.

Keyword

Patent ductus arteriosus; ligation; neonatal intensive care unit; very low birth weight infants

MeSH Terms

Ductus Arteriosus, Patent/*surgery
Humans
Infant, Newborn
*Infant, Very Low Birth Weight
Intensive Care Units, Neonatal/*statistics & numerical data
Ligation/*methods
Treatment Outcome

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