J Korean Med Sci.  1997 Aug;12(4):369-373. 10.3346/jkms.1997.12.4.369.

Mixed hepatoblastoma in an adult--a case report and literature review

• Ahn HJ
• Kwon KW
• Choi YJ
• Kim HJ
• Hong SP
• Oh D
• Chung JS

• KMID: 1081061
• DOI: http://doi.org/10.3346/jkms.1997.12.4.369

Abstract

Hepatoblastoma is thought to originate from embryonal hepatic tissue, and most of these tumors occur in children under the age of 2 years. Hepatoblastoma in adults is extremely rare, and the prognosis is much worse than the mixed hepatoblastoma of childhood. We experienced a case of mixed hepatoblastoma in a 51 year old female patient. She had been suffering from a mild pain and a palpable lump in the epigastric area. Serum AFP was 43,850 ng/ml. Computerized tomography and selective abdominal angiography showed a large low-density mass. With a suspicion of hepatocellular carcinoma of the left lobe, a left lateral segmentectomy was performed. The external surface showed a huge protruding mass and the capsule was previously ruptured. On section, the tumor was a 11 x 7 cm sized expanding mass which had a variegated surface composed of yellow-white friable tissue with multifocal hemorrhagic areas. Microscopic examination revealed a tumor consisted of epithelial and mesenchymal elements. The mesenchymal cells were spindle in shape and proliferated over the whole tumor with focal osteosarcomatous differentiation. The epithelial components showed well-differentiated hepatocellular carcinoma-like areas, poorly differentiated acinar or tubular structures.

MeSH Terms

Case Report
Female
Hepatoblastoma/diagnosis*
Human
Liver Neoplasms/diagnosis*
Middle Age
Tomography, X-Ray Computed