J Korean Med Sci.  1997 Oct;12(5):427-432. 10.3346/jkms.1997.12.5.427.

Relationship of transforming growth factor beta 1 to angiogenesis in gastric carcinoma

• Choi YH
• Choi KC
• Park YE

• KMID: 1081035
• DOI: http://doi.org/10.3346/jkms.1997.12.5.427

Abstract

Transforming growth factor-beta (TGF-beta) comprises a group of multifunctional regulatory proteins, whose effects include angiogenesis. The expression of TGF-beta 1 in gastric carcinomas (70 cases) has been determined and related to pathological features and microvessel count by immunohistochemical staining for TGF-beta 1 and Factor VIII related antigen. Prominent reactivity for TGF-beta 1 was associated with the depth of invasion (r = 0.2; p < 0.05) and increased microvessel count (r = 0.5; p < 0.05). Also, the microvessel count had a significant correlation with invasiveness (r = 0.34; p < 0.05) and lymph node metastasis (r = 0.28; p < 0.05). These findings indicate that TGF-beta 1 may have a role in tumor invasion and angiogenesis.

MeSH Terms

Adult
Aged
Carcinoma/secondary
Carcinoma/pathology
Carcinoma/blood supply*
Female
Human
Immunoenzyme Techniques
Male
Middle Age
Neovascularization, Pathologic*
Stomach Neoplasms/etiology
Stomach Neoplasms/blood supply*
Transforming Growth Factor beta/physiology*