Korean J Radiol.  2008 Aug;9(4):382-385. 10.3348/kjr.2008.9.4.382.

Angiomyofibroblastoma Arising from the Posterior Perivesical Space: a Case Report with MR Findings

• Lim KJ
• Moon JH
• Yoon DY
• Cha JH
• Lee IJ
• Min SJ

• KMID: 1076467
• DOI: http://doi.org/10.3348/kjr.2008.9.4.382

Abstract

Angiomyofibroblastoma is a rare benign soft tissue neoplasm that predominantly occurs in the genital region of middle-aged women. We present a case of an angiomyofibroblastoma that involved the posterior perivesical space in a 48-year-old woman. We have documented the magnetic resonance imaging features of this case.

Keyword

Angiomyofibroblastoma (AMFB), posterior perivesical space; Magnetic resonance (MR)

MeSH Terms

Angiofibroma/*diagnosis/pathology
Angiomyoma/*diagnosis/pathology
Female
Humans
*Magnetic Resonance Imaging
Middle Aged
Vaginal Neoplasms/*diagnosis/pathology

Figure

• 

  Fig. 1 Angiomyofibroblastoma in 48-year-old woman. A, B. T2-weighted axial (A) and sagittal (B) MR images show well-defined, oval shape mass with heterogeneous signal intensity in posterior perivesical space (arrows). Note nodular or curvilinear dark signal intensities within tumor. C. On T1-weighted axial MR image (10-minutes after contrast administration) at same level as in A, mass (arrows) is isointense to muscle. D-F. Contrast-enhanced dynamic sagittal MR images (D: baseline, E: 1-minute, F: 3-minute delayed image) show strong, homogeneous and persistent enhancement of mass (arrows). G. Photomicrograph of surgical specimen shows compactly arranged epithelioid ovoid or blunt spindle shaped tumor cells having monotonous small nuclei and eosinophilic cytoplasm. There are prominent ectatic blood vessels, which are surrounded by eosinophilic or myxoid fibrous stroma (Hematoxylin & Eosin staining, original magnification, ×200). H. Immunohistochemical staining shows that neoplastic cells are strongly positive (brown color) for actin (original magnification, ×200).

Reference

1. Fletcher CD, Tsang WY, Fisher C, Lee KC, Chan JK. Angiomyofibroblastoma of the vulva. A benign neoplasm distinct from aggressive angiomyxoma. Am J Surg Pathol. 1992. 16:373–382.

2. Ockner DM, Sayadi H, Swanson PE, Ritter JH, Wick MR. Genital angiomyofibroblastoma. Comparison with aggressive angiomyxoma and other myxoid neoplasms of skin and soft tissue. Am J Clin Pathol. 1997. 107:36–44.

3. Kitamura H, Miyao N, Sato Y, Matsukawa M, Tsukamoto T, Sato T. Angiomyofibroblastoma of the female urethra. Int J Urol. 1999. 6:268–270.

4. Nasu K, Fujisawa K, Takai N, Miyakawa I. Angiomyofibroblastoma of the vulva. Int J Gynecol Cancer. 2002. 12:228–231.

5. McCluggage WG, White RG. Angiomyofibroblastoma of the vagina. J Clin Pathol. 2000. 53:803.

6. Mortele KJ, Lauwers GJ, Mergo PJ, Ros PR. Perineal angiomyofibroblastoma: CT and MR findings with pathologic correlation. J Comput Assist Tomogr. 1999. 23:687–689.