Korean J Hepatol.
2008 Mar;14(1):102-107. 10.3350/kjhep.2008.14.1.102.
A case of ticlopidine induced acute cholestatic hepatitis and pure red cell aplasia
- Affiliations
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- 1Korea University Medical College Guro Hospital, Department of Internal Medicine, Seoul, Korea. je_yeon@hotmail.com
- 2Korea University Medical College Guro Hospital, Department of Pathology, Seoul, Korea.
- 3Korea University Medical College Ansan Hospital, Department of Laboratory Medicine, Ansan, Korea.
- KMID: 1073335
- DOI: http://doi.org/10.3350/kjhep.2008.14.1.102
Abstract
- Ticlopidine inhibits platelet aggregation and provides beneficial secondary prevention of cerebrovascular and coronary artery disease. Frequently reported adverse effects of ticlopidine include diarrhea, nausea, and rash. However, to our knowledge, there are only a few published reports of the simultaneous occurrence of cholestatic hepatitis and pure red cell aplasia. Here we report a patient with simultaneous severe cholestatic hepatitis and pure red cell aplasia associated with ticlopidine. Although these adverse effects are rare, periodic hematological and liver function tests are recommended after starting ticlopidine.
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