J Vet Sci.  2011 Mar;12(1):99-101. 10.4142/jvs.2011.12.1.99.

Effects of anti-glaucoma drugs on resistive index of the medial long posterior ciliary artery using color Doppler imaging in Beagle dogs

Affiliations
  • 1Department of Veterinary Medical Imaging, College of Veterinary Medicine, Chungnam National University, Daejeon 305-764, Korea.
  • 2Research Institute of Life Sciences, Gyeongsang National University, Jinju 660-701, Korea. lhc@gnu.ac.kr

Abstract

Color Doppler imaging (CDI) was carried out to evaluate the effects of anti-glaucoma drugs on ophthalmic circulation using CDI-derived resistive index (RI) values. CDI was performed on nine Beagle dogs, and RI values were calculated for the medial long posterior ciliary artery before and after the administration of anti-glaucoma drugs. A significant increase in RI values was found after topical administration of levobunolol (p < 0.05) or dipivefrin (p < 0.05). Pilocarpine showed no effects on RI values after topical administration. The results suggest that some anti-glaucoma drugs could affect ophthalmic blood flow.

Keyword

anti-glaucoma drugs; color Doppler imaging; dogs; resistive index

MeSH Terms

Adrenergic Agonists/pharmacology
Animals
Ciliary Arteries/*drug effects/*ultra
Dogs
Epinephrine/analogs & derivatives/therapeutic use
Eye/*blood supply
Female
Glaucoma/*drug therapy
Levobunolol/therapeutic use
Male
Ocular Physiological Phenomena
Pilocarpine/therapeutic use
Ultra
*Vascular Resistance
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