Yonsei Med J.  1991 Dec;32(4):292-302. 10.3349/ymj.1991.32.4.292.

Studies on the prenatal chromosomal analysis and the changes of maternal serum alpha-fetoprotein following chorionic villus sampling

• Yang YH
• Lee MS
• Park YW
• Kim SK
• Sung HR
• Lee CH
• Kim IK

• KMID: 1057638
• DOI: http://doi.org/10.3349/ymj.1991.32.4.292

Abstract

Transcervical chorionic villus sampling (CVS) was performed in 174 patients between 7 & 12 menstrual weeks of pregnancy opting for prenatal diagnosis. Advanced maternal age was the most common indication for CVS (39.7%). The sampling success rate was 95.4% (166/174), representing 88.9% at 7 to 8 weeks, 98.9% at 9 to 10 weeks & 92.7% at 11 to 12 weeks gestation. In 139 of 174 patients (80%), successful sampling was accomplished in one or two catheter passages only. Four spontaneous fetal losses (2.3%) occurred. The cytogenetic analysis routinely used was the direct overnight & long-term culture methods which revealed 4 abnormalities (2.4%). To date, 90 of the women have been delivered & all infants are doing well and the remaining 65 pregnancies are continuing uneventually. Maternal serum alphafetoprotein (MSAFP) concentration was determined in 72 patients immediately before & after CVS. A significant increase of 20% or more, comparable to pre CVS levels, was noted immediately after sampling in 56 of 72 patients (77.8%). The increase in MSAFP concentration correlated with the amount of villi sampled (r = 0.498, p less than 0.001) & with the number of sampling attempts (p less than 0.05). Estimated CVS related fetomaternal hemorrhage (FMH) ranged from 0.005 to 0.1552 ml and in 5 of 72 patients (6.90%) 0.06 ml or more of FMH was noted. Two of the 5 patients had FMH of 0.1 ml or more.

Keyword

Chorionic villus sampling(CVS); maternal serum alpha-fetoprotein (MSAFP); fetomaternal hemorrhage(FMH)

MeSH Terms

Chorionic Villi Sampling/*adverse effects
*Chromosome Aberrations
Female
Fetomaternal Transfusion/etiology
Human
Pilot Projects
Pregnancy/*blood
Rh Isoimmunization/etiology
Support, Non-U.S. Gov't
alpha-Fetoproteins/*analysis