Korean J Parasitol.  2004 Jun;42(2):51-56. 10.3347/kjp.2004.42.2.51.

Susceptibility of several strains of mice to Echinostoma hortense infection

Affiliations
  • 1Department of Parasitology and Institute of Basic Medical Science, Wonju College of Medicine, Yonsei University, Wonju 220-701, Korea.
  • 2Department of Microbiology Wonju College of Medicine, Yonsei University, Wonju 220-701, Korea.
  • 3Department of Biomedical Laboratory Science and Institute of Health Science, College of Health Science, Yonsei University Wonju 220-710, Korea. ryangys@dragon.yonsei.ac.kr

Abstract

Susceptibilities of 5 different mice strains, including C3H/HeN, BALB/c, C57BL6, FvB and ICR, to Echinostoma hortense infection, was evaluated. The worm expulsion rate, worm size and egg production were observed from 1 to 8 weeks after infection with 30 metacercariae. C3H/HeN and ICR mice showed the highest worm maturation rates. The worm recovery rate and the number of eggs per gram (EPG) of feces was also higher in C3H/HeN and ICR mice than in BALB/c, C57BL6, and FvB mice. It is suggested that E. hortense is highly infectious to ICR and C3H/HeN mice, but not to the other strains of mice. Based on the results obtained, we believe that the susceptibility of different mouse strains to E. hortense infection is dependent on the genetic and immunologic background of mice.

Keyword

Echinostoma; immune; mice; infection

MeSH Terms

Animals
Echinostoma/*growth & development
Echinostomiasis/genetics/*parasitology
Feces/parasitology
Female
Genetic Predisposition to Disease
Intestines/parasitology
Mice/*parasitology
Mice, Inbred BALB C
Mice, Inbred C3H
Mice, Inbred C57BL
Mice, Inbred ICR
Parasite Egg Count
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