Korean J Dermatol.  2014 Jan;52(1):1-6.

Effect of Horse Oil on Anti-bacterial, Inflammatory Cytokines, and Type I Collagen Expressions in Human HaCaT Keratinocytes and Fibroblasts

  • 1Department of Dermatology, Keimyung University School of Medicine, Daegu, Korea. janylove99@dsmc.or.kr
  • 2Research Institute of Korea Horse Industry, Sung Duck University, Yeongcheon, Korea.
  • 3Department of Health Science, Daegu Haany University, Daegu, Korea.
  • 4Department of Herbal Pharmacology, College of Oriental Medicine, Daegu Haany University, Daegu, Korea.


Anti-inflammation, anti-bactericidal, and collagen synthesis are important for health skin conditions. However, the effect of horse oil on anti-inflammation, anti-bactericidal, and collagen synthesis is largely unknown.
The aim of this study was to evaluate the anti-bactericidal, anti-inflammatory, and synthesis of type I collagen of horse oil.
Anti-bacterial effect was evaluated by disc diffusion test. Expressions of inflammatory cytokines were studied by RT-PCR analysis, real time PCR. Type I collagen expression was evaluated by Western blot in human HaCaT kertinocytes and fibroblasts.
Our data showed that horse oil exerted anti-bacterial effect on P.acnes and S.aureus. Expression of IL-10 was increased by horse oil-treated HaCaT cells. In addition, increased expression of type I collagen was observed in horse oil-treated human skin fibroblasts.
Horse oil exerts an anti-bactericidal effect against P.acnes and S.aureus. In addition, anti-inflammatory and anti-aging effects of horse oil will be mediated by up-regulation of IL-10 and type I collagen, respectively.


Anti-bactericidal effect; Horse oil; IL-10; Type I collagen
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