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Qualification and application of liquid chromatography-quadrupole time-offlight mass spectrometric method for the determination of carisbamate in rat plasma and prediction of its human pharmacokinetics using physiologically based pharmacokinetic modeling

Lee Bi, Lim Jh, Park MH, Shin SH, Byeon JJ, Choi Jm, Park Sj, Park Mj, Park Y, Shin YG

Carisbamate is an antiepileptic drug and it also has broad neuroprotective activity and anticonvulsant reaction. In this study, a liquid chromatography-quadrupole time-of-flight mass spectrometric (LC-qTOF-MS) method was developed and applied...
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Spine Surgery Using Augmented Reality

Park SM, Kim HJ, Yeom JS, Shin YG

STUDY DESIGN: Review article. OBJECTIVES: To present the latest knowledge on spine surgery using augmented reality (AR). SUMMARY OF LITERATURE REVIEW: AR is a new technology that simulates interactions with real-world surroundings...
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A Case of Middle Ear Implantation Using the Vibrant Soundbridge in a Patient with Bilateral Mixed Hearing Loss

Shin YG, Gu JW, Kang JW, Song MH

It is challenging to achieve sufficient hearing gain in patients with mixed hearing loss. In chronic middle ear diseases, conventional passive reconstructive surgeries often result in suboptimal hearing gain and...
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Influence of Fatigability on the Timing of Reassessment in the Treatment of Posterior Canal Benign Paroxysmal Positional Vertigo

Kim CH, Shin JE, Shin YG, Song MH, Shim DB

BACKGROUND AND OBJECTIVES: The early assessment of treatment is not done for benign paroxysmal positional vertigo (BPPV) since the well-known phenomenon of fatigability after a repeated positional test can mimic...
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Spinal Enumeration by Morphologic Analysis of Spinal Variants: Comparison to Counting in a Cranial-To-Caudal Manner

Yun S, Park S, Park JG, Huh JD, Shin YG, Yun JH

OBJECTIVE: To compare the spinal enumeration methods that establish the first lumbar vertebra in patients with spinal variants. MATERIALS AND METHODS: Of the 1446 consecutive patients who had undergone computed tomography...
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Compensation of the Postural Instability in Patients with Acute Unilateral Vestibular Neuritis: The Usefulness of Computerized Dynamic Posturography as an Objective Indicator

Park JW, Shin YG, Gu JW, Song MH, Shim DB

BACKGROUND AND OBJECTIVES: The aim of this study was to evaluate the usefulness of computerized dynamic posturography (CDP) in patients with acute vestibular neuritis (AVN) by identifying the recovery period...
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Magnetic resonance imaging and pathological characteristics of pure mucinous carcinoma in the breast according to echogenicity on ultrasonography

Shin YG, Kim EK, Kim MJ, Yoon JH, Moon HJ

PURPOSE: The aim of this study was to explore the clinical and pathological characteristics of pure mucinous breast carcinoma (PMBC) according to internal echogenicity on ultrasonography (US). METHODS: Thirty-three patients with...
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Detection of Breast Abnormalities on Enhanced Chest CT: Correlation with Breast Composition on Mammography

Cho EM, Kang H, Shin YG, Yun JH, Oh KS, Park S

PURPOSE: To investigate the capability of enhanced chest computed tomography (CT) for detecting breast abnormalities and to assess the influence of breast composition on this detectability. MATERIALS AND METHODS: From 2000...
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A Patient with Sudden Hearing Loss with Vertigo Showing Exclusive Posterior Semicircular Canal Abnormality

Gu JW, Shin YG, Song MH, Shim DB

It is known that about 30% of patients with sudden hearing loss present with vertigo or dizziness. In clinical practice, this is called sudden hearing loss with vertigo (SHLV) although...
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Pseudo-Spontaneous Nystagmus and Head-Shaking Nystagmus in Horizontal Canal Benign Paroxysmal Positional Vertigo

Shin YG, Gu JW, Kang JW, Song MH, Shim DB

OBJECTIVES: The purpose of this study was to examine the clinical manifestations and significance of pseudo-spontaneous nystagmus (PSN) and head-shaking nystagmus (HSN) in horizontal canal benign paroxysmal positional vertigo (HC-BPPV). METHODS:...
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Prediction of pharmacokinetics and drug-drug interaction potential using physiologically based pharmacokinetic (PBPK) modeling approach: A case study of caffeine and ciprofloxacin

Park MH, Shin SH, Byeon JJ, Lee GH, Yu BY, Shin YG

Over the last decade, physiologically based pharmacokinetics (PBPK) application has been extended significantly not only to predicting preclinical/human PK but also to evaluating the drug-drug interaction (DDI) liability at the...
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Various Nystagmus Patterns and Their Clinical Significance in Benign Paroxysmal Positional Vertigo of Anterior Semicircular Canal

Park JW, Shin YG, Gu JW, Song MH, Shim DB

OBJECTIVE: The purpose of this study was to identify the diverse patterns of nystagmus and analyze their clinical significance in benign paroxysmal positional vertigo (BPPV) of the anterior semicircular canal. METHODS:...
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The Influence of Sleep Position on Benign Paroxysmal Positional Vertigo

Shin YG, Park JW, Gu JW, Song MH, Shim DB

OBJECTIVE: The purpose of this study was to identify the influence of sleep position on benign paroxysmal positional vertigo (BPPV). METHODS: Four hundred sixty patients diagnosed as posterior or horizontal canal...
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Comprehensive Factors Influencing Quality of Life of Elders Utilizing Senior Welfare Centers

Kim EK, Shin YG, Jo EJ, Moon DS, Park KM, Kim EK, Lee SJ, Kim HJ, Ko HS

PURPOSE: The purpose of this study was to investigate the influencing factors on the quality of life of elders. METHODS: Data were collected from August 25, September 1, 2014, and participants...
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Development and Verification of Nested PCR Assay for Detection of Tobacco rattle virus in Plant Quarantine

Lee S, Lee JY, Shin YG, Lee SH, Ahn TY

Tobacco rattle virus (TRV) is a plant pathogen belonging to the Group IV positive-sense single-stranded RNA viruses. TRV causes disease in various plants (e.g., potato, tomato and tobacco), for which...
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Ultrasonographic Features of Metastatic Lymph Nodes in Papillary Thyroid Microcarcinomas and Macrocarcinomas

Shin YG, Kang H, Joh YD, Jeong KS, Kim BS

PURPOSE: To analyze ultrasonographic (US) features of metastatic lymph nodes (LNs) in papillary thyroid microcarcinomas (PTMC) and in papillary thyroid macrocarcinomas. MATERIALS AND METHODS: The study reviewed US findings of 273...
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Validation of a method for the determination of thiocyanate in human plasma by UV/VIS spectrophotometry and application to a Phase I clinical trial of GDC-0425

Shin YG, Meijering , van Heuveln FH, Wieling J, Halladay J, Sahasranaman S, Hop CE

The development and validation of a method for the determination of concentrations of thiocyanate in human plasma are described here. A modified colorimetric method of Bowler was used with the...
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Clinical Characteristics of Horizontal Canal Benign Paroxysmal Positional Vertigo with Persistent Geotropic Direction Changing Positional Nystagmus

Ko KM, Song MH, Park JW, Lee JH, Shin YG, Shim DB

OBJECTIVE: The purpose of this study was to identify the clinical characteristics of horizontal canal benign paroxysmal positional vertigo (h-BPPV) with persistent geotropic direction changing positional nystagmus (DCPN). METHODS: One hundred...
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Factors Influencing Glycemic Control Response of Sitagliptin

Kim GW, Kim JH, Lee MY, Shin JY, Shin YG, Ha EH, Chung CH

BACKGROUND: Dipeptidyl peptidase 4 (DPP-4) inhibitors are proposed to reduce blood glucose in type 2 diabetes by prolonging the activity of circulating incretins. However, the factors that affect the efficacy...
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Role of HbA1c in the Screening of Diabetes Mellitus in a Korean Rural Community

Kim JH, Kim GW, Lee MY, Shin JY, Shin YG, Koh SB, Chung CH

BACKGROUND: Recently, the measurement of glycated hemoglobin (HbA1c) was recommended as an alternative to fasting plasma glucose or oral glucose tolerance tests for diagnosing diabetes mellitus (DM). In this study,...
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