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Relationship between Hearing Loss and Dementia Differs According to the Underlying Mechanism

Jung J, Bae SH, Han JH, Kwak SH, Nam GS, Lee PH, Sohn YH, Yun M, Ye BS

Background and Purpose The associations between hearing loss (HL) and the mechanisms underlying cognitive impairment (CI) remain unclear. We evaluated the effects of clinical factors, vascular magnetic resonance imaging (MRI)...
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N-acetylcysteine decreases airway inflammation and responsiveness in asthma by modulating claudin 18 expression

Lee PH, Hong J, Jang AS

Background/Aims: N-acetylcysteine (NAC) affects signaling pathways involved in apoptosis, angiogenesis, cell growth and arrest, redox-regulated gene expression, and the inflammatory response. However, it is not known how the signal mechanism...
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Emerging Concepts of Motor Reserve in Parkinson’s Disease

Chung SJ, Lee JJ, Lee PH, Sohn YH

The concept of cognitive reserve (CR) in Alzheimer’s disease (AD) explains the differences between individuals in their susceptibility to AD-related pathologies. An enhanced CR may lead to less cognitive deficits...
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Hepatocyte and mesenchymal stem cell co-transplantation in rats with acute liver failure

Ho CM, Chen YH, Chien CS, Ho SL, Chen HL, Hu RH, Lee PH

Background: Cell therapy is considered a potential alternative to liver transplantation in acute liver failure (ALF). We aimed to evaluate the add-on therapeutic benefit of hepatocyte and mesenchymal stem cell...
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Structural and Resting-State Brain Alterations in Trauma-Exposed Firefighters: Preliminary Results

Park YW, Jun S, Noh J, Chung SJ, Han S, Lee PH, Kim C, Lee SK

Purpose To analyze the altered brain regions and intrinsic brain activity patterns in trauma-exposed firefighters without posttraumatic stress disorder (PTSD). Materials and Methods Resting-state functional MRI (rsfMRI) was performed for all...
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Association between Olfactory Deficit and Motor and Cognitive Function in Parkinson’s Disease

Yoo HS, Chung SJ, Lee YH, Ye BS, Sohn YH, Lee PH

Objective To investigate whether baseline olfactory dysfunction in Parkinson’s disease (PD) patients is associated with baseline and longitudinal motor and cognitive function. Methods We recruited 228 drug-naïve PD patients who were...
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The Safe Conduct of Echocardiographic Studies During the COVID-19 Pandemic: Perspectives and Experience from a Tertiary Echocardiography Laboratory in Singapore

Koh CH, Chiong SC, Lee PT, Ding ZP, Ewe SH

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Validation of the Korean Version of the Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease Rating Scale

Choi JH, Lee JY, Cho JW, Ko SB, Ahn TB, Kim SJ, Cheon SM, Kim JS, Kim YJ, Ma HI, Baik JS, Lee PH, Chung SJ, Kim JM, Song IU, Kim HJ, Sung YH, Kwon DY, Lee JH, Kim JY, Kim JS, Yun JY, Kim HJ, Hong JY, Kim MJK, Youn J, Kim JSK, Oh ES, Yang HJ, Yoon WT, You S, Kwon KY, Park HE, Lee SY, Kim Y, Kim HT, Park MY

Background and Purpose Impulse-control disorder is an important nonmotor symptom of Parkinson's disease (PD) that can lead to financial and social problems, and be related to a poor quality of life....
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A Characteristic Finding of Spontaneous Coronary Artery Dissection by Computed Tomographic Angiography

Kim AR, Koo HJ, Lee PH

No abstract available.
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Serum Calprotectin Is a Potential Marker in Patients with Asthma

Lee YG, Hong Js, Lee PH, Lee Jh, Park SW, Kim DJ, Jang AS

Background: Calprotectin is the major cytosolic protein in neutrophil granulocytes. Although asthma is known to cause eosinophilic inflammation, some patients with asthma have non-eosinophilic inflammation, which is characterized by local neutrophilic...
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Validation Study of the Official Korean Version of the Movement Disorder Society-Unified Parkinson’s Disease Rating Scale

Park J, Koh SB, Kwon KY, Kim SJ, Kim JW, Kim JS, Park KW, Paik JS, Sohn YH, Ahn JY, Oh E, Youn J, Lee JY, Lee PH, Jang W, Kim HJ, Jeon BS, Chung SJ, Cho JW, Cheon SM, Kang SY, Park MY, Park S, Huh YE, Kang SJ, Kim HT

Background and Purpose: The Movement Disorder Society-Sponsored Revision of the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) is widely used for estimating the symptoms of Parkinson’s disease. Translation and validation of...
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Infusion of Human Mesenchymal Stem Cells Improves Regenerative Niche in Thioacetamide-Injured Mouse Liver

Kao YH, Lin YC, Lee PH, Lin CW, Chen PH, Tai TS, Chang YC, Chou MH, Chang CY, Sun CK

BACKGROUND: This study investigated whether xenotransplantation of human Wharton’s jelly-derived mesenchymal stem cells (WJ-MSCs) reduces thioacetamide (TAA)-induced mouse liver fibrosis and the underlying molecular mechanism. METHODS: Recipient NOD/SCID mice were injected...
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A Case of Abnormal Postures in the Left Extremities after Pontine Hemorrhage: Dystonia or Pseudodystonia?

Park CW, Chung SJ, Sohn YH, Lee PH

It is difficult to determine the pathoanatomical correlates of dystonia because of its complex pathophysiology, and most cases with secondary dystonia are associated with basal ganglia lesions. Moreover, it is...
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Subtypes of Sleep Disturbance in Parkinson's Disease Based on the Cross-Culturally Validated Korean Version of Parkinson's Disease Sleep Scale-2

Yang HJ, Kim HJ, Koh SB, Kim JS, Ahn TB, Cheon SM, Cho JW, Kim YJ, Ma HI, Park MY, Baik JS, Lee PH, Chung SJ, Kim JM, Song IU, Kim JY, Sung YH, Kwon DY, Lee JH, Lee JY, Kim JS, Yun JY, Kim HJ, Hong JY, Kim MJ, Youn J, Kim JS, Oh ES, Yoon WT, You S, Kwon KY, Park HE, Lee SY, Kim Y, Kim HT, Kim SJ

BACKGROUND AND PURPOSE: This study aimed to determine the clinimetric properties of the Korean version of Parkinson's Disease Sleep Scale-2 (K-PDSS-2) and whether distinct subtypes of sleep disturbance can be...
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Heterogeneous Patterns of Striatal Dopamine Loss in Patients with Young- versus Old-Onset Parkinson's Disease: Impact on Clinical Features

Chung SJ, Yoo HS, Lee YH, Lee PH, Sohn YH

OBJECTIVE: Ample evidence has suggested that age at onset of Parkinson's disease (PD) is associated with heterogeneous clinical features in individuals. We hypothesized that this may be attributed to different...
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Unexpected Stenosis within Significantly Enlarged Distal Vessel after Successful Coronary Chronic Total Occlusion Recanalization

Lee PH, Lee SW, Habara M, Nasu K

No abstract available.
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The Influence of Body Mass Index at Diagnosis on Cognitive Decline in Parkinson's Disease

Yoo HS, Chung SJ, Lee PH, Sohn YH, Kang SY

BACKGROUND AND PURPOSE: Associations between alterations in body mass index (BMI) and cognitive function have been reported in Parkinson's disease (PD). We investigated whether the BMI at a PD diagnosis...
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Stent Selection in Complex Coronary Interventions: Thinking Complex?

Lee PH, Lee SW

No abstract available.
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Early experience and favorable clinical outcomes of everolimus-eluting bioresorbable scaffolds for coronary artery disease in Korea

Kwon O, Ahn JM, Kang DY, Kang SH, Lee PH, Kang SJ, Lee SW, Kim YH, Lee CW, Park SW, Park DW, Park SJ

BACKGROUND/AIMS: Compared with metallic drug-eluting stents (DES), bioresorbable vascular scaffolds (BVS) may further improve long-term outcomes of percutaneous coronary intervention (PCI) in patients with coronary artery disease. We report our...
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Impact of the Endothelial Tight Junction Protein Claudin-5 on Clinical Profiles of Patients With COPD

Kim BG, Lee PH, Lee SH, Baek AR, Park JS, Lee J, Park SW, Kim DJ, Park CS, Jang AS

PURPOSE: The tight junction protein claudin-5 (CLDN5) is critical to the control of endothelial cellular polarity and pericellular permeability. The role of CLDN5 in chronic obstructive pulmonary disease (COPD) remains...
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