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Flos magnoliae constituent fargesin has an anti-allergic effect via ORAI1 channel inhibition

Hong PTL, Kim HJ, Kim WK, Nam JH

Flos magnoliae (FM), the dry flower buds of Magnolia officinalis or its related species, is a traditional herbal medicine commonly used in Asia for symptomatic relief of and treating allergic...
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SP-8356, a (1S)-(-)-Verbenone Derivative, Inhibits the Growth and Motility of Liver Cancer Cells by Regulating NF-κB and ERK Signaling

Kim DH, Yong HJ, Mander S, Nguyen HT, Nguyen LP, Park HK, Cha HK, Kim WK, Hwang JI

Liver cancer is a common tumor and currently the second leading cause of cancer-related mortality globally. Liver cancer is highly related to inflammation as more than 90% of liver cancer...
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Protective efficacy of attenuated Salmonella Typhimurium strain expressing BLS, Omp19, PrpA, or SOD of Brucella abortus in goats

Leya M, Kim WK, Ochirkhuyag E, Yu EC, Kim YJ, Yeo Y, Yang MS, Han SS, Lee JH, Tark D, Hur J, Kim B

Background: Attenuated Salmonella strain can be used as a vector to transport immunogens to the host antigen-binding sites. Objectives: The study aimed to determine the protective efficacy of attenuated Salmonella strain expressing...
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Validation of Sanitation Management Standards for Vegetable Preparation with No-Cook Step Based on Microbiological Analysis

Kim WK, Ryu K

This study evaluated the sanitation management standards for vegetable preparation processes without a cooking stage. The aerobic plate counts (APC), coliform counts, and Escherichia coli of the samples at each...
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Nootkatol prevents ultraviolet radiation-induced photoaging via ORAI1 and TRPV1 inhibition in melanocytes and keratinocytes

Woo JH, Nam DY, Kim HJ, Hong PTL, Kim WK, Nam JH

Skin photoaging occurs due to chronic exposure to solar ultraviolet radiation (UV), the main factor contributing to extrinsic skin aging. Clinical signs of photoaging include the formation of deep, coarse...
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Gardenia jasminoides extract and its constituent, genipin, inhibit activation of CD3/CD28 co-stimulated CD4+ T cells via ORAI1 channel

Kim HJ, Nam YR, Woo J, Kim WK, Nam JH

Gardenia jasminoides (GJ) is a widely used herbal medicine with antiinflammatory properties, but its effects on the ORAI1 channel, which is important in generating intracellular calcium signaling for T cell...
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Luteolin reduces fluid hypersecretion by inhibiting TMEM16A in interleukin-4 treated Calu-3 airway epithelial cells

Kim HJ, Woo J, Nam YR, Seo Y, Namkung W, Nam JH, Kim WK

Rhinorrhea in allergic rhinitis (AR) is characterized by the secretion of electrolytes in the nasal discharge. The secretion of Cl– and HCO3 – is mainly regulated by cystic fibrosis transmembrane...
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Risk factors of postoperative remote intracerebral hemorrhage after craniotomy for ruptured cerebral aneurysms

Lee I, Park CW, You CJ, Choi DH, Park K, Kim YB, Kim WK, Yee GT, Kim MJ, Kim EY

Objective: We aimed to identify the relation between perioperative cerebrospinal fluid (CSF) drain through lumbar drainage (LD) and development of postoperative (POP) remote intracerebral hemorrhage (rICH) in craniotomy to treat...
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Effect of saccharin on inflammation in 3T3-L1 adipocytes and the related mechanism

Kim HL, Ha AW, Kim WK

BACKGROUND/OBJECTIVES: Excessive intake of simple sugars induces obesity and increases the risk of inflammation. Thus, interest in alternative sweeteners as a sugar substitute is increasing. The purpose of this study...
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Pioglitazone Alters the Proteomes of Normal Bladder Epithelial Cells but Shows No Tumorigenic Effects

Shahid M, Kim M, Yeon A, Jin P, Kim WK, You S, Kim J

Purpose: Pioglitazone, an antihyperglycemic drug, is widely used in diabetes mellitus patients with insulin resistance. Although pioglitazone is known to have a potential link to bladder cancer (BC), there have...
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Asthma predictive index as a useful diagnostic tool in preschool children: a cross-sectional study in Korea

Lee DH, Kwon JW, Kim HY, Seo JH, Kim HB, Lee SY, Jang GC, Song DJ, Kim WK, Jung YH, Hong SJ, Shim JY

Background: It is challenging to diagnose asthma in preschool children. The asthma predictive index (API) has been used to predict asthma and decide whether to initiate treatment in preschool children. Purpose:...
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Job Satisfaction of Nutritionist: Effect on Organizational Commitment and Turnover Intention in Public Health Center

Park SE, Seo MY, Kim WK, Ryu K

This study examined the job satisfaction of nutritionists, and its effect on organizational commitment andturnover intention in public health centers. The response data of 174 nutritionists were analyzed. The overallaverage...
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Differential expression of microRNAs in the saliva of patients with aggressive periodontitis: a pilot study of potential biomarkers for aggressive periodontitis

Lee NH, Lee E, Kim YS, Kim WK, Lee YK, Kim SH

Purpose: The aim of this study was to compare microRNA (miRNA) gene expression in saliva using miRNA polymerase chain reaction (PCR) arrays in healthy and aggressive periodontitis (AP) patients. Methods: PCR...
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Associated Factors for Asthma Severity in Korean Children: A Korean Childhood Asthma Study

Lee E, Song DJ, Kim WK, Suh DI, Baek HS, Shin M, Yoo Y, Kim JT, Kwon JW, Jang GC, Lim DH, Yang HJ, Kim HS, Seo JH, Woo SI, Kim HY, Shin YH, Lee JS, Yoon J, Jung S, Han M, Eom E, Yu J

PURPOSE: Childhood asthma has a considerable social impact and economic burden, especially in severe asthma. This study aimed to identify the proportion of childhood asthma severity and to evaluate associated...
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Effects of Outdoor Activities in Forests on Atopic Dermatitis

Kim WK, Kim W, Woo JM

BACKGROUND: The aim of this study was to determine the effects of out-door activities in the forest environment, the so-called "forest therapy program," among children with atopic dermatitis (AD). METHODS: A...
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Surgical Ablation of Atrial Fibrillation in Patients Undergoing Bioprosthetic Valve Replacement

Pyo W, Park SJ, Kim WK, Kim HJ, Kim JB, Jung SH, Joo SJ, Chung CH, Lee JW

BACKGROUND: Scarce data have been reported on the efficacy of concomitant atrial fibrillation (AF) ablation in patients undergoing bioprosthetic valve replacement. METHODS: From 2001 and 2014, 146 consecutive patients (69.3±9.4 years,...
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The current status and issue of food allergen labeling in Korea

Jeon YH, Kim HH, Park YM, Jang GC, Kim HY, Yum HY, Kim J, Ahn K, Min TK, Pyun BY, Lee S, Kim KW, Kim YH, Lee J, Lee SY, Kim WK, Song TW, Kim JH, Lee YJ, The Korean Academy of Pediatric Allergy and Respiratory Diseases, Food Allergy and Atopic Dermatitis Study Group

With increasing need to prevent serious food allergy reactions, Korean food allergen labeling regulation has been revised repeatedly. This paper aims to summarize current statuses of food allergen labeling in...
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Infantile Anaphylaxis in Korea: a Multicenter Retrospective Case Study

Jeon YH, Lee S, Ahn K, Lee SY, Kim KW, Kim HH, Kim JH, Yum HY, Kim WK, Park YM, Song TW, Kim J, Lee YJ, Jang GC, Jeong K, Kim YH, Min TK, Pyun BY, on behalf of the Food Allergy and Atopic Dermatitis (FAAD) Study Group in the Korean Academy of Pediatric Allergy and Respiratory Disease

BACKGROUND: Anaphylaxis is increasing in young children. The aim of the present study was to analyze the clinical characteristics of anaphylaxis in Korean infants, with a focus on food triggers. METHODS:...
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Intraoperative Frozen Cytology of Central Nervous System Neoplasms: An Ancillary Tool for Frozen Diagnosis

Kang M, Chung DH, Kim NR, Cho HY, Ha SY, Lee S, An J, Seok JY, Yie GT, Yoo CJ, Lee SG, Kim EY, Kim WK, Son S, Sym SJ, Shin DB, Hwang HY, Kim EY, Lee KC

BACKGROUND: Pathologic diagnosis of central nervous system (CNS) neoplasms is made by comparing light microscopic, immunohistochemical, and molecular cytogenetic findings with clinicoradiologic observations. Intraoperative frozen cytology smears can improve the...
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Clinical Outcomes of One Day Small-incision Lenticule Extraction Compared with Scheduled Methods for Myopic Patients

Kim WK, Ryu IH, Kim JS, Jeon GH, Lee IS, Kim HS, Kim JK

PURPOSE: To evaluate the clinical outcomes of one day small incision lenticule extraction (SMILE), which was performed on the same day as preoperative examinations in myopic patients. METHODS: This study included...
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