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Proarrhythmogenic Effect of the L532P and N588K KCNH2 Mutations in the Human Heart Using a 3D Electrophysiological Model

Heikhmakhtiar AK, Abrha AT, Jeong DU, Lim KM

Background: Atrial arrhythmia is a cardiac disorder caused by abnormal electrical signaling and transmission, which can result in atrial fibrillation and eventual death. Genetic defects in ion channels can cause...
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Cytotoxicity of natural killer cells on canine mammary carcinoma cells

Jeong DU, Byeon JS, Gu NY, Jung M, Kim EH, Kim HS, Cho IS, Song JY, Hyun BH, Lee J

Natural killer (NK) cells play have a crucial role in the early phase of immune responses against various pathogens. We compared characteristics of canine NK cells against two canine mammary...
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Effect of Placenta-Derived Mesenchymal Stem Cells in a Dementia Rat Model via Microglial Mediation: a Comparison between Stem Cell Transplant Methods

Cho JS, Lee J, Jeong DU, Kim HW, Chang WS, Moon J, Chang JW

PURPOSE: Loss of cholinergic neurons in the hippocampus is a hallmark of many dementias. Administration of stem cells as a therapeutic intervention for patients is under active investigation, but the...
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Differentiation potential of canine mesenchymal stem cells on hydrogel scaffold-based three-dimensional environment

Gu NY, Park MJ, Lee J, Byeon JS, Jeong DU, Cho IS, Cha SH

Mesenchymal stem cells (MSCs) are useful candidates for tissue engineering and cell therapy. Physiological cell environment not only connects cells to each other, but also connects cells to the extracellular...
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Tumorsphere formation and cancer stem cell characterization of REM134 canine mammary carcinoma cells

Byeon JS, Lee J, Jeong DU, Gu NY, Cho IS, Cha SH

Canine mammary tumors are among the most frequently observed cutaneous tumors in female dogs. Cancer stem cells (CSCs), referred to as tumor-initiating cells, are thought to have properties similar to...
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Periodic Limb Movements in Sleep is Associated with Increased Mortality

Choi JW, Song JS, Lee YJ, Jeong DU

OBJECTIVE: To elucidate the association between periodic limb movements in sleep (PLMS) and mortality. METHODS: Nocturnal polysomnographic recordings of 1,344 subjects obtained from 1995 to 2008 were reviewed. The subjects were...
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Differential Effects of Obesity on Obstructive Sleep Apnea Syndrome according to Age

Lee YJ, Lee YJ, Jeong DU

OBJECTIVE: To evaluate the effect of obesity on obstructive sleep apnea syndrome (OSAS) by age in relation to anthropometric measurements. METHODS: The medical records of 1,110 participants diagnosed with OSAS were...
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Transdermal Nicotine Patch Effects on EEG Power Spectra and Heart Rate Variability During Sleep of Healthy Male Adults

Choi JB, Lee YJ, Jeong DU

OBJECTIVE: The effect of transdermal nicotine patch on sleep physiology is not well established. The current study aimed to examine the influence of nicotine patch on homeostatic sleep propensity and...
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The Changes in Polysomnographic Sleep Variables by Periodic Limb Movements During Sleep

Choi J, Choi JW, Lee YJ, Koo JW, Jeong DU

OBJECTIVES: Periodic limb movement disorder (PLMD) has been debated with regard to its clinical significance and diagnostic criteria. The current diagnostic criterion for PLMD in adults has been changed from...
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Preliminary Study on Quantitative Sleep EEG Characteristics in Patients with Schizophrenia

Oh SM, Lee YJ, Kim JW, Choi JW, Jeong DU

We used quantitative electroencephalography (EEG) spectral analysis to compare activity in the bilateral frontal, central, and occipital areas in nine patients with schizophrenia and ten healthy control subjects during standard...
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Depressed REM Sleep Behavior Disorder Patients Are Less Likely to Recall Enacted Dreams than Non-Depressed Ones

Lee HG, Choi JW, Lee YJ, Jeong DU

OBJECTIVE: REM sleep behavior disorder (RBD) is associated with psychiatric symptoms, such as anxiety and alexithymia. However, only a few studies on the relationship between depression and RBD have been...
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Sleep EEG Characteristics in Young and Elderly Patients with Obstructive Sleep Apnea Syndrome

Lee YJ, Kim JW, Lee YJ, Jeong DU

OBJECTIVE: In the present study, it was hypothesized that the sleep electroencephalogram (EEG) characteristics of young (55 yrs) OSAS patients would differ. METHODS: We analyzed 76 sleep EEG recordings from OSAS...
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Ataxic Form of Central Pontine Myelinolysis Developed during Alcohol Withdrawal in a Chronic Alcoholic

Shin DS, Jeong D, Yang KI, Park HK, Oh HG

Central pontine myelinolysis (CPM) is well-recognized osmotic demyelination syndrome that is related to various conditions such as rapid correction of hyponatremia and chronic alcoholism. Acute ataxia as a sole clinical...
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Delayed Hemichorea Syndrome Associated with Nonketotic Hyperglycemia

Lee SC, Jeong D, Yang KI, Park HK, Oh HG

Hemichorea have been reported in patients with nonketotic hyperglycemia. Usually, hemichorea and hyperglycemia are concomitant. A 73-year-old woman was admitted for investigation of an acute hemichorea. T1-weighted brain magnetic resonance...
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Acute Painful Neuropathy Induced by Rapid Correction of Serum Glucose Levels in a Diabetic Patient

Shin DS, Lee SC, Kim DE, Jeong D

Treatment-induced neuropathy in diabetes (also referred to as insulin neuritis) is considered a rare iatrogenic small fiber neuropathy caused by an abrupt improvement in glycemic control in the setting of...
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Comparative Effects of Mattress Type on Subjective and Objective Sleep Quality: A Preliminary Study

Choi JW, Lee YJ, Kim S, Lee J, Jeong DU

OBJECTIVES: We aimed to evaluate the effects of mattress type on both objective and subjective sleep quality in healthy good sleepers. METHODS: Fifteen healthy good sleepers with a mean age of...
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A Study on Vitamin C Content of Nutrition Emphasized Products

Jeong DU, Lee HO, Kim YK, Om AS

OBJECTIVES: Vitamin C has various functions such as antioxidative effect and supporting absorption of iron (Fe). Aim of this present study was to provide vitamin C nutrition information and to...
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Basal Forebrain Cholinergic Deficits Reduce Glucose Metabolism and Function of Cholinergic and GABAergic Systems in the Cingulate Cortex

Jeong DU, Oh JH, Lee JE, Lee J, Cho ZH, Chang JW, Chang WS

PURPOSE: Reduced brain glucose metabolism and basal forebrain cholinergic neuron degeneration are common features of Alzheimer's disease and have been correlated with memory function. Although regions representing glucose hypometabolism in...
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Comparison of Families with and without a Suicide Prevention Plan Following a Suicidal Attempt by a Family Member

Cho HD, Kim NY, Gil HW, Jeong DS, Hong SY

The frequency and extent of the existence of a familial suicide prevention plan may differ across cultures. The aim of this work was, therefore, to determine how common it was...
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Gender Differences of Direct and Relational Aggression in Children and Adolescents

Jeong DU, Kim JW, Hong HJ, Kim SJ, Lee NH, Yang JS, Ahn SI, Im WY, Jhung K

OBJECTIVES: The aim of this study was to investigate the gender differences of direct aggression and relational aggression in Korean elementary and middle school students. METHODS: Parents of 946 elementary school...
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