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Rapid resolution of bone marrow necrosis mimicking relapse of pediatric acute lymphoblastic leukemia

Lee JW, Kim S, Jang PS, Chung NG, Cho B, Kim Y

No abstract available.
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Outcome and prognostic factors of children with Philadelphia chromosome-positive acute lymphoblastic leukemia treated with imatinib followed by allogeneic hematopoietic cell transplantation in first remission

Shin J, Lee NY, Kim S, Lee JW, Jang PS, Chung NG, Cho B

BACKGROUND: Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) is a subset of ALL with poor prognosis. Here, we analyzed the outcomes and prognostic factors of children with Ph+ ALL who...
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Allogeneic hematopoietic stem cell transplantation in congenital hemoglobinopathies with myeloablative conditioning and rabbit anti-thymocyte globulin

Park BK, Kim HS, Kim S, Lee JW, Park YS, Jang PS, Chung NG, Jeong DC, Cho B

BACKGROUND: Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative therapy for β-thalassemia major (TM) and sickle cell disease (SCD) in children. Graft-versus-host disease (GVHD) and treatment-related mortality (TRM) remain...
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Treatment and response of autoimmune cytopenia occurring after allogeneic hematopoietic cell transplantation in children

Hwang-Bo S, Kim SK, Lee JW, Jang PS, Chung NG, Jeong DC, Cho B, Kim HK

BACKGROUND: Autoimmune cytopenia (AIC) is a rare complication of allogeneic hematopoietic cell transplantation (HCT). In this study, we reviewed the diagnosis, treatment and response to therapy for pediatric patients with...
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Outcome and Prognostic Factors for ETV6/RUNX1 Positive Pediatric Acute Lymphoblastic Leukemia Treated at a Single Institution in Korea

Lee JW, Kim SK, Jang PS, Chung NG, Jeong DC, Kim M, Cho B, Kim HK

PURPOSE: ETV6/RUNX1 (+) acute lymphoblastic leukemia (ALL), which is the most common genetic subtype of pediatric ALL, has a favorable prognosis. In this study, we analyzed the outcome of ETV6/RUNX1...
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A Novel Syntaxin 11 Gene (STX11) Mutation c.650T>C, p.Leu217Pro, in a Korean Child With Familial Hemophagocytic Lymphohistiocytosis

Sultanova , Kim SK, Lee JW, Jang PS, Chung NG, Cho B, Park J, Kim Y, Kim M

We report the first Far Eastern case of a Korean child with familial hemophagocytic lymphohistiocytosis (HLH) caused by a novel syntaxin 11 (STX11) mutation. A 33-month-old boy born to non-consanguineous...
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Hepatic veno-occlusive disease may develop in secondary iron overloaded mice after allogeneic hematopoietic stem cell transplantation with total body irradiation

Yeom MY, Kim YJ, Chung NG, Lee JW, Jang PS, Cho B, Kye CS, Jeong DC

BACKGROUND: The outcome of hematopoietic stem cell transplantation (HSCT) is poor in patients with secondary iron overload (SIO). We evaluated the relationship between SIO and veno-occlusive disease (VOD) in an...
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A Small Outbreak of Measles in 2013: In a Single Hospital in Northern Gyeonggi-do

Kim MJ, Kim SH, Kim SU, Jang MJ, Lee HS, Kim YH, Han JW, Kim JT, Jang PS

PURPOSE: This study analyzed a small outbreak of measles at a single hospital located in northern Gyeonggi-do in 2013. METHODS: We reviewed the medical records of measles patients at The Catholic...
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Anti-leukemic properties of deferasirox via apoptosis in murine leukemia cell lines

Jeon SR, Lee JW, Jang PS, Chung NG, Cho B, Jeong DC

BACKGROUND: Although deferasirox (DFX) is reported to have anti-tumor effects, its anti-leukemic activity remains unclear. We evaluated the effect of DFX treatment on two murine lymphoid leukemia cell lines, and...
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Clinical and Laboratory Features of Severe Neutropenia Developed in Childhood

Lee JH, Kim SH, Kim SK, Lee JW, Jang PS, Kim M, Chung NG, Cho B, Kim HK

BACKGROUND: Neutropenia is not uncommon in children. We performed this study to investigate the etiology, clinical course and laboratory characteristics for prediction of recovery in children with severe neutropenia. METHODS: In...
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Efficacy of imatinib mesylate-based front-line therapy in pediatric chronic myelogenous leukemia

Oh HJ, Cho MS, Lee JW, Jang PS, Chung NG, Cho B, Kim HK

PURPOSE: Despite the established role of imatinib (IM) in chronic myelogenous leukemia (CML) in adults, there are few reports on its efficacy in children. In this study, we compared the...
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Utility of a multiplex reverse transcriptase-polymerase chain reaction assay (HemaVision) in the evaluation of genetic abnormalities in Korean children with acute leukemia: a single institution study

Kim HJ, Oh HJ, Lee JW, Jang PS, Chung NG, Kim M, Lim J, Cho B, Kim HK

  • KMID: 2353170
  • Korean J Pediatr.
  • 2013 Jun;56(6):247-253.
PURPOSE: In children with acute leukemia, bone marrow genetic abnormalities (GA) have prognostic significance, and may be the basis for minimal residual disease monitoring. Since April 2007, we have used...
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Evaluation of risk for graft-versus-host disease in children who receive less than the full doses of mini-dose methotrexate for graft-versus-host disease prophylaxis in allogeneic hematopoietic stem cell transplantation

Yum SK, Choi HY, Lee JW, Jang PS, Chung NG, Jeong DC, Cho B, Kim HK

PURPOSE: The use of cyclosporine and mini-dose methotrexate (MTX) is a common strategy for graft-versus-host disease (GVHD) prophylaxis in allogeneic transplants. We investigated whether patients who receive fewer than the...
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Immune reconstitution after allogeneic hematopoietic stem cell transplantation in children: a single institution study of 59 patients

Kim HO, Oh HJ, Lee JW, Jang PS, Chung NG, Cho B, Kim HK

PURPOSE: Lymphocyte subset recovery is an important factor that determines the success of hematopoietic stem cell transplantation (HSCT). Temporal differences in the recovery of lymphocyte subsets and the factors influencing...
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Evaluation of changes in random blood glucose and body mass index during and after completion of chemotherapy in children with acute lymphoblastic leukemia

Bang KW, Seo SY, Lee JW, Jang PS, Jung MH, Chung NG, Cho B, Jeong DC, Suh BK, Kim HK

PURPOSE: Improved survival of patients with childhood acute lymphoblastic leukemia (ALL) has drawn attention to the potential for late consequences of previous treatments among survivors, including metabolic syndrome. In this...
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Outcome of allogeneic hematopoietic stem cell transplantation for childhood acute lymphoblastic leukemia in second complete remission: a single institution study

Lee EJ, Han JY, Lee JW, Jang PS, Chung NG, Jeong DC, Cho B, Kim HK

PURPOSE: The survival rate for childhood acute lymphoblastic leukemia (ALL) has improved significantly. However, overall prognosis for the 20 to 25% of patients who relapse is poor, and allogeneic hematopoietic...
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Cytarabine Monotherapy as Bridging Treatment for Hematopoietic Stem Cell Transplantation in Children with Juvenile Myelomonocytic Leukemia

Suh WS, Cho MS, Lee JW, Jang PS, Chung NG, Jeong DC, Cho B, Kim HK

  • KMID: 2049276
  • Clin Pediatr Hematol Oncol.
  • 2012 Oct;19(2):86-91.
BACKGROUND: Mutations leading to hyperactivation of the RAS pathway play a critical role in the pathogenesis of juvenile myelomonocytic leukemia (JMML). Allogeneic hematopoietic stem cell transplantation (HSCT) is the only...
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Prognostic Implications of the NIH Consensus Criteria in Children with Chronic Graft-versus-Host Disease

Lee JW, Lee DH, Jang PS, Yi MS, Chung NG, Cho B, Jeong DC, Kim HK

PURPOSE: In this study, we analyzed a cohort of children with chronic graft-versus-host disease (GvHD) according to the NIH consensus classification (NCC) in order to observe whether global assessment at...
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CD30 Activation Induced Eosinophil Apoptosis is Mediated by Caspase-9

Lee HJ, Lee KY, Kim YJ, Jang PS, Yoon JS, Kim HH, Koh YY, Kim JT, Lee JS

  • KMID: 2315084
  • Pediatr Allergy Respir Dis.
  • 2011 Jun;21(2):115-122.
PURPOSE: Although CD30 is known to be expressed more on eosinophils undergoing apoptosis, it is still not known how CD30 activation leads to eosinophil apoptosis. In this study, we evaluated...
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A case of hemolytic uremic syndrome preceded by intussusception

Ko EY, Kim JY, Lee HJ, Lee HS, Han JW, Kim YH, Kim JT, Cheong HI, Jang PS

Hemolytic-uremic syndrome (HUS) is the most common cause of acute renal failure in young children. It is classically characterized by the triad of microangiopathic hemolytic anemia, thrombocytopenia, and uremia. Further,...
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