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Two Cases of Recurred Vertigo Following Perilymphatic Oval Window Fistula Repair

Kim HJ, Chung WH

The traumatic perilymphatic fistula (PLF) can cause hearing loss and disabling dizziness. These symptoms can be recovered spontaneously or by surgical repair. However, even after surgical PLF repair, patients may suffer...
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Drug hypersensitivity reactions in Asia: regional issues and challenges

Thong BY, Lucas M, Kang HR, Chang YS, Li PH, Tang MM, Yun J, Fok JS, Kim BK, Nagao M, Rengganis , Tsai YG, Chung WH, Yamaguchi , Rerkpattanapipat T, Kamchaisatian W, Leung TF, Yoon HJ, Zhang L, Latiff AH, Fujisawa T, Thien F, Castells M, Demoly P, Wang JY, Pawankar R

There are geographical, regional, and ethnic differences in the phenotypes and endotypes of patients with drug hypersensitivity reactions (DHRs) in different parts of the world. In Asia, aspects of drug...
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A Case of Lipoma in the Middle Ear

Park SI, Park MH, Ahn J, Chung WH

Lipoma is a common benign tumor found at various sites in the body, but it is rarely encountered in the middle ear. We report a case of a 5-month-old girl...
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Case Series Outcomes of Cochlear Implantation in Children with Noonan Syndrome

Chang YS, Ahn J, Hong SH, Kim EY, Chung WH, Cho YS, Moon IJ

BACKGROUND AND OBJECTIVES: Hearing loss is a common complication associated with Noonan syndrome (NS), and the level of hearing loss for NS patients with sensorineural loss ranged from normal to...
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Symptomatic Calcific Deposition in Posterior Cruciate Ligament of the Knee

Chung WY, Park SJ, Sung SY

Calcium deposition disease, including calcific tendinitis, rarely affects the knee joint. Only a few cases can be found in the literatures and there is no case report of symptomatic calcific...
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Two Cases of Localized Myeloperoxidase-Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Manifested with Intractable Otitis Media

Lee E, Chung WH

Localized form of myeloperoxidase-antineutrophil cytoplasmic antibody-associated vasculitis (MPO-AAV) in the ear is a rare disease. It manifests as a sudden otalgia with hearing loss accompanied by dizziness and facial nerve...
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Novel Patched 1 Mutations in Patients with Gorlin-Goltz Syndrome Strategic Treated by Smoothened Inhibitor

Hsu SW, Lin CY, Wang CW, Chung WH, Yang CH, Chang YY

We studied a family with Gorlin-Goltz syndrome. The novel mutations of our cases were located on the 21st exon of the PTCH1 gene (c.3450C>G). The father, who received a strategic...
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Comparison of Endoscopic Tympanoplasty to Microscopic Tympanoplasty

Choi N, Noh Y, Park W, Lee JJ, Yook S, Choi JE, Chung WH, Cho YS, Hong SH, Moon IJ

OBJECTIVES: This study aimed to compare the outcome of endoscopic and microscopic tympanoplasty. METHODS: This was a retrospective comparative study of 73 patients (35 males and 38 females) who underwent type...
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Multicenter Randomized Study on the Efficacy of Isosorbide in Patients with Mèniére's Disease

Park HW, Chung WH, Kim SH, Kim KS, Chung JW, Chae SW, Koo JW, Kim BG, Goh EK, Han GC

OBJECTIVES: Mèniére's disease is one of the most common causes of episodic vestibular syndrome that shows symptom complexes of recurrent vertigo, hearing loss, tinnitus and ear fullness. Isosorbide (Isobide) is...
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Expression of neurotrophic factors in injured spinal cord after transplantation of human-umbilical cord blood stem cells in rats

Chung HJ, Chung WH, Lee JH, Chung DJ, Yang WJ, Lee AJ, Choi CB, Chang HS, Kim DH, Suh HJ, Lee DH, Hwang SH, Do SH, Kim HY

We induced percutaneous spinal cord injuries (SCI) using a balloon catheter in 45 rats and transplanted human umbilical cord blood derived mesenchymal stem cells (hUCB-MSCs) at the injury site. Locomotor...
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A Case of Idiopathic Massive Rice Bodies in the Knee Joint without Rheumatoid Arthritis or Tuberculosis and a Literature Review

Chung WY, Song JS, Oh HE, Park HJ

Rice bodies are materials with an amorphous nucleus and a fibrin layer found floating in the synovial space and bursa. These bodies have often been detected in patients with rheumatoid...
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Isolated Traumatic Radial Head Anterior Dislocation Treated with Open Reduction in Children

Chung W, Park H, Sung S

Isolated traumatic radial head anterior dislocation without associated injuries is uncommon in pediatric patients. If diagnosed on time, most cases can be reduced by closed reduction. In some cases, the...
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Diagnostic Criteria for Meniere's Disease

Lopez-Escamez JA, Careyb J, Chung WH, Goebeld JA, Magnusson , Mandala M, Newman-Tokerg DE, Strupp M, Suzuki M, Trabalzini F, Bisdorff A

This paper presents diagnostic criteria for Meniere's disease jointly formulated by the Classification Committee of the Barany Society, The Japan Society for Equilibrium Research, the European Academy of Otology and...
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Effect of Next-Generation Exome Sequencing Depth for Discovery of Diagnostic Variants

Kim K, Seong MW, Chung WH, Park SS, Leem S, Park W, Kim J, Lee K, Park RW, Kim N

Sequencing depth, which is directly related to the cost and time required for the generation, processing, and maintenance of next-generation sequencing data, is an important factor in the practical utilization...
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Recent advances of pharmacogenomics in severe cutaneous adverse reactions: immune and nonimmune mechanisms

Dao RL, Su SC, Chung WH

Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS) are severe cutaneous adverse reactions (SCAR) which are majorly caused by drugs. Though the...
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Clinical Usefulness of Bronchoalveolar Lavage Cellular Analysis and Lymphocyte Subsets in Diffuse Interstitial Lung Diseases

Lee W, Chung WS, Hong KS, Huh J

BACKGROUND: Diffuse interstitial lung diseases (DILDs) form a part of a heterogeneous group of respiratory diseases. Bronchoalveolar lavage (BAL) analysis has been used for differential diagnosis of DILDs, but their...
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Two Cases of Barotraumatic Perilymph Fistula Mimicking Atypical Benign Paroxysmal Positional Vertigo with Sudden Hearing Loss

Lee JJ, Ryu G, Moon IJ, Chung WH

Barotraumatic perilymph fistula is difficult to diagnose and needs diagnosis of suspicion. Symptoms like hearing loss, tinnitus, ear fullness and positional dizziness can develop following barotrauma such as valsalva, nose...
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Comparison of Histological and Biochemical Findings with Magnetic Resonance Imaging on the Degeneration Severity of Meniscus

Chung WY, Sung SY, Chae DS

PURPOSE: The aim of this study is to determine whether degeneration severities of meniscus assessed using magnetic resonance imaging (MRI) would well estimate those assessed using histological and biochemical examinations. MATERIALS...
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Cochlear Implantation for Profound Hearing Loss After Multimodal Treatment for Neuroblastoma in Children

Ryu NG, Moon IJ, Chang YS, Kim BK, Chung WH, Cho YS, Hong SH

OBJECTIVES: Neuroblastoma (NBL) predominantly affects children under 5 years of age. Through multimodal therapy, including chemotherapy, radiotherapy, surgery, and peripheral blood stem cell transplantation, the survival rate in patients with...
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Submicroscopic Deletions of Immunoglobulin Heavy Chain Gene (IGH) in Precursor B Lymphoblastic Leukemia with IGH Rearrangements

Huh J, Mun YC, Yoo ES, Seong CM, Chung WS

Translocations leading to fusions between the immunoglobulin heavy chain gene (IGH) and various partner genes have been reported in B-cell precursor acute lymphoblastic leukemia (B-ALL). However, submicroscopic deletions within IGH...
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