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Painful Hashimoto Thyroiditis in a 7-Year-Old Girl: Differential Diagnosis and Medical Treatment

Park G, Song K, Shin HJ, Chae HW

Painful Hashimoto thyroiditis (HT) is a rare pediatric condition. Because of the rarity of painful HT, it can be misdiagnosed as other thyroid diseases, and there is limited evidence regarding...
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Midfacial soft tissue changes after maxillary expansion using micro-implant-supported maxillary skeletal expanders in young adults: A retrospective study

Nguyen H, Shin JW, Giap HV, Kim KB, Chae HS, Kim YH, Choi HW

Objective: The aim of this retrospective study was to assess the midfacial soft tissue changes following maxillary expansion using micro-implantsupported maxillary skeletal expanders (MSEs) in young adults by cone-beam computerized...
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Ten-Year Trends of Metabolic Syndrome Prevalence and Nutrient Intake among Korean Children and Adolescents: A Population-Based Study

Park SI, Suh J, Lee HS, Song K, Choi Y, Oh JS, Choi HS, Kwon A, Kim HS, Kim JH, Chae HW

Purpose: Metabolic syndrome (MetS) comprises a cluster of risk factors for future cardiovascular and metabolic diseases. Only a few recent studies have reported the trend in the prevalence of MetS...
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Diagnosis and Treatment of Growth Hormone Deficiency: A Position Statement from Korean Endocrine Society and Korean Society of Pediatric Endocrinology

Kim JH, Chae HW, Chin SO, Ku CR, Park KH, Lim DJ, Kim KJ, Lim JS, Kim G, Choi YM, Ahn SH, Jeon MJ, Hwangbo Y, Lee JH, Kim BK, Choi YJ, Lee KA, Moon SS, Ahn HY, Choi HS, Hong SM, Shin DY, Seo JA, Kim SH, Oh S, Yu SH, Kim BJ, Shin CH, Kim SW, Kim CH, Lee EJ

Growth hormone (GH) deficiency is caused by congenital or acquired causes and occurs in childhood or adulthood. GH replacement therapy brings benefits to body composition, exercise capacity, skeletal health, cardiovascular...
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Effect of agricultural pesticide on precocious puberty in urban children: an exploratory study

Suh J, Choi HS, Kwon A, Chae HW, Kim HS

Background: The incidence of precocious puberty has increased throughout the 20th century. The association between precocious puberty and endocrine disrupting chemicals including agricultural pesticides has been a subject of global...
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A novel compound heterozygous mutation of the AIRE gene in a patient with autoimmune polyendocrine syndrome type 1

Suh J, Choi HS, Kwon A, Chae HW, Lee JS, Kim HS

Autoimmune polyendocrine syndrome type 1 (APS-1), or autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy is a rare, autosomal recessive autoimmune disease caused by a mutation of the autoimmune regulator (AIRE) gene. The main symptom...
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Influence of heritability on craniofacial soft tissue characteristics of monozygotic twins, dizygotic twins, and their siblings using Falconer's method and principal components analysis

Song J, Chae HS, Shin JW, Sung J, Song YM, Baek SH, Kim YH

OBJECTIVE: The purpose of this study was to investigate the influence of heritability on the craniofacial soft tissue cephalometric characteristics of monozygotic (MZ) twins, dizygotic (DZ) twins, and their siblings...
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A New Integrated Newborn Screening Workflow Can Provide a Shortcut to Differential Diagnosis and Confirmation of Inherited Metabolic Diseases

Ko JM, Park KS, Kang Y, Nam SH, Kim Y, Park I, Chae HW, Lee SM, Lee KA, Kim JW

PURPOSE: We developed a new workflow design which included results from both biochemical and targeted gene sequencing analysis interpreted comprehensively. We then conducted a pilot study to evaluate the benefit...
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Respiratory failure in a diabetic ketoacidosis patient with severe hypophosphatemia

Choi HS, Kwon A, Chae HW, Suh J, Kim DH, Kim HS

Phosphate is essential in regulating human metabolic processes, and severe hypophosphatemia can induce neurologic and hematological complications and result in respiratory failure and cardiac dysfunction. Therefore, correction of severe hypophosphatemia...
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Visceral fat thickness and its associations with pubertal and metabolic parameters among girls with precocious puberty

Kim DW, Suh J, Kwon AR, Chae HW, Yoon CS, Kim HS, Kim DH

PURPOSE: This study aimed to investigate associations of central obesity with sexual maturation and metabolic parameters in Korean girls with precocious puberty. METHODS: This retrospective study evaluated data from 72 girls...
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The 2017 Korean National Growth Charts for children and adolescents: development, improvement, and prospects

Kim JH, Yun S, Hwang SS, Shim JO, Chae HW, Lee YJ, Lee JH, Kim SC, Lim D, Yang SW, Oh K, Moon JS, The Committee for the Development of Growth Standards for Korean Children and Adolescents, The Committee for School Health and Public Health Statistics, the Korean Pediatric Society, Division of Health and Nutrition Survey, Korea Centers for Disease Control and Prevention

Growth charts are curves or tables that facilitate the visualization of anthropometric parameters, and are widely used as an important indicator when evaluating the growth status of children and adolescents....
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Design of the long-term observational cohort study with recombinant human growth hormone in Korean children: LG Growth Study

Chung S, Yoo JH, Choi JH, Rhie YJ, Chae HW, Kim JH, Hwang IT, Shin CH, Kim EY, Lee KH

PURPOSE: Regarding recombinant human growth hormone (rhGH) use in the pediatric population, no long-term follow-up data are available for Korean patients. To fill in the gap of knowledge, a registry...
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Effect of the Orally Active Growth Hormone Secretagogue MK-677 on Somatic Growth in Rats

Lee J, Kwon A, Chae HW, Lee WJ, Kim TH, Kim HS

PURPOSE: Growth hormone secretagogues (GHSs) possess the ability to release growth hormone (GH) in the body. This study aimed to investigate the effects of MK-677, an orally active GHS, on...
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Insulin resistance and bone age advancement in girls with central precocious puberty

Hur JH, Park S, Jung MK, Kang SJ, Kwon A, Chae HW, Kim HS, Kim DH

PURPOSE: Precocious puberty has significantly increased recently. While obesity is associated with puberty timing, the relationship between obesity and central precocious puberty (CPP) remains controversial. The purpose of this study...
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Clinical manifestations of Rathke’s cleft cysts and their natural progression during 2 years in children and adolescents

Jung JE, Jin J, Jung MK, Kwon A, Chae HW, Kim DH, Kim HS

PURPOSE: Rathke’s cleft cyst (RCC) is an asymptomatic benign lesion. With increased interest in pediatric endocrinology, the prevalence of RCCs in children is also increasing. However, the clinical relevance and...
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Teeth discoloration during orthodontic treatment

Baik UB, Kim H, Chae HS, Myung JY, Chun YS

OBJECTIVE: Teeth discoloration is a rare orthodontic complication. The aim of this study was to report the clinical progression of discoloration during orthodontic treatment. METHODS: Discolored teeth, detected during orthodontic treatment...
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Retrospective Analysis of Difficult Intubation

Lim CH, Kim YJ, Kim JH, Jeong JS

OBJECTIVES: We analyzed retrospectively incidence, management, and predictors of difficult intubation, which have been known through practical cases. METHODS: A total of 217 cases of difficult intubation (DI) between 2010 and...
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Diabetes mellitus due to agenesis of the dorsal pancreas in a patient with heterotaxy syndrome

Jung JE, Hur JH, Jung MK, Kwon A, Chae HW, Kim DH, Kim HS

Heterotaxy syndrome (HS) is a congenital disorder resulting from an abnormal arrangement of visceral organs across the normal left-right axis in the embryonic period. HS is usually associated with multiple...
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A 1-month-old infant with chylomicronemia due to GPIHBP1 gene mutation treated by plasmapheresis

Jung MK, Jin J, Kim HO, Kwon A, Chae HW, Kang SJ, Kim DH, Kim HS

Chylomicronemia is a severe type of hypertriglyceridemia characterized by chylomicron accumulation that arises from a genetic defect in intravascular lipolysis. It requires urgent and proper management, because serious cases can...
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A boy with 46,X,+mar presenting gynecomastia and short stature

Kim KE, Kim YJ, Jung MK, Chae HW, Kwon AR, Lee WJ, Kim DH, Kim HS

A 15-year-old boy was referred due to gynecomastia and short stature. He was overweight and showed the knuckle-dimple sign on the left hand, a short fourth toe on the left...
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