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The Role of PI3K/AKT Pathway and NADPH Oxidase 4 in Host ROS Manipulation by Toxoplasma gondii

Choi HG, Gao FF, Zhou W, Sun PR, Yuk JM, Lee YH, Cha GH

Dendritic cell is one of the first innate immune cell to encounter T. gondii after the parasite crosses the host intestinal epithelium. T. gondii requires intact DC as a carrier...
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Dipenyleneiodonium Induces Growth Inhibition of Toxoplasma gondii through ROS Induction in ARPE-19 Cells

Sun PR, Gao FF, Choi HG, Zhou W, Yuk JM, Kwon J, Lee YH, Cha GH

Based on the reactive oxygen species (ROS) regulatory properties of diphenyleneiodonium (DPI), we investigated the effects of DPI on host-infected T. gondii proliferation and determined specific concentration that inhibit the...
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Modulated Gene Expression of Toxoplasma gondii Infected Retinal Pigment Epithelial Cell Line (ARPE-19) via PI3K/Akt or mTOR Signal Pathway

Zhou W, Quan JH, Gao FF, Ismail HA, Lee YH, Cha GH

Due to the critical location and physiological activities of the retinal pigment epithelial (RPE) cell, it is constantly subjected to contact with various infectious agents and inflammatory mediators. However, little...
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Fasciola hepatica: Infection Status of Freshwater Snails Collected from Gangwon-do (Province), Korea

Lee JH, Quan JH, Choi IW, Park GM, Cha GH, Kim HJ, Yuk JM, Lee YH

Fasciola hepatica is a trematode that causes zoonosis, mainly in cattle and sheep, and occasionally in humans. Few recent studies have determined the infection status of this fluke in Korea....
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IL-12 and IL-23 Production in Toxoplasma gondii- or LPS-Treated Jurkat T Cells via PI3K and MAPK Signaling Pathways

Ismail HA, Kang BH, Kim JS, Lee JH, Choi IW, Cha GH, Yuk JM, Lee YH

IL-12 and IL-23 are closely related in structure, and have been shown to play crucial roles in regulation of immune responses. However, little is known about the regulation of these...
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Production of IL-1β and Inflammasome with Up-Regulated Expressions of NOD-Like Receptor Related Genes in Toxoplasma gondii-Infected THP-1 Macrophages

Chu JQ, Shi G, Fan YM, Choi IW, Cha GH, Zhou Y, Lee YH, Quan JH

Toxoplasma gondii is an obligate intracellular parasite that stimulates production of high levels of proinflammatory cytokines, which are important for innate immunity. NLRs, i.e., nucleotide-binding oligomerization domain (NOD)-like receptors, play...
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Involvement of PI3K/AKT and MAPK Pathways for TNF-alpha Production in SiHa Cervical Mucosal Epithelial Cells Infected with Trichomonas vaginalis

Yang JB, Quan JH, Kim YE, Rhee YE, Kang BH, Choi IW, Cha GH, Yuk JM, Lee YH

Trichomonas vaginalis induces proinflammation in cervicovaginal mucosal epithelium. To investigate the signaling pathways in TNF-alpha production in cervical mucosal epithelium after T. vaginalis infection, the phosphorylation of PI3K/AKT and MAPK...
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Genetic Diversity of Schistosoma haematobium Eggs Isolated from Human Urine in Sudan

Quan JH, Choi IW, Ismail HA, Mohamed AS, Jeong HG, Lee JS, Hong ST, Yong TS, Cha GH, Lee YH

The genetic diversity of Schistosoma haematobium remains largely unstudied in comparison to that of Schistosoma mansoni. To characterize the extent of genetic diversity in S. haematobium among its definitive host...
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Fasciola hepatica in Snails Collected from Water-Dropwort Fields using PCR

Kim HY, Choi IW, Kim YR, Quan JH, Ismail HA, Cha GH, Hong SJ, Lee YH

Fasciola hepatica is a trematode that causes zoonosis mainly in cattle and sheep and occasionally in humans. Fascioliasis has been reported in Korea; however, determining F. hepatica infection in snails...
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Trichomonas vaginalis Metalloproteinase Induces mTOR Cleavage of SiHa Cells

Quan JH, Choi IW, Yang JB, Zhou W, Cha GH, Zhou Y, Ryu JS, Lee YH

Trichomonas vaginalis secretes a number of proteases which are suspected to be the cause of pathogenesis; however, little is understood how they manipulate host cells. The mammalian target of rapamycin...
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Kinetics of IL-23 and IL-12 Secretion in Response to Toxoplasma gondii Antigens from THP-1 Monocytic Cells

Quan JH, Zhou W, Cha GH, Choi IW, Shin DW, Lee YH

IL-23 and IL-12 are structurally similar and critical for the generation of efficient cellular immune responses. Toxoplasma gondii induces a strong cell-mediated immune response. However, little is known about IL-23...
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Gene Expression Profiles in Genetically Different Mice Infected with Toxoplasma gondii: ALDH1A2, BEX2, EGR2, CCL3 and PLAU

Ismail HA, Quan JH, Wei Z, Choi IW, Cha GH, Shin DW, Lee YH, Song CJ

Toxoplasma gondii can modulate host cell gene expression; however, determining gene expression levels in intermediate hosts after T. gondii infection is not known much. We selected 5 genes (ALDH1A2, BEX2,...
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Proteomic Analysis of Toxoplasma gondii KI-1 Tachyzoites

Choi SH, Kim TY, Park SG, Cha GH, Shin DW, Chai JY, Lee YH

We studied on the proteomic characteristics of Toxoplasma gondii KI-1 tachyzoites which were originally isolated from a Korean patient, and compared with those of the well-known virulent RH strain using...
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Seroprevalence of Toxoplasma gondii Infection and Characteristics of Seropositive Patients in General Hospitals in Daejeon, Korea

Shin DW, Cha DY, Hua QJ, Cha GH, Lee YH

To figure out the epidemiological status and relevance with other diseases in toxoplasmosis, we checked serum IgG antibody titers of 1,265 patients and medical records of seropositive patients. Seropositive rates...
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Antigenemia and Specific IgM and IgG Antibody Responses in Rabbits Infected with Toxoplasma gondii

Quan JH, Hassan HA, Cha GH, Shin DW, Lee YH

In this experiment, the correlation between antigenemia and specific antibody responses in Toxoplasma gondii-infected rabbits was assessed. We injected 1,000 T. gondii tachyzoites (RH) subcutaneously into 5 rabbits. Parasitemia, circulating...
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Pharyngoesophageal reconstruction

Cha GH, Kim JC, Lee KH, Suh DB, Suh JS

Microvascular tissue transfers have facilitated primary closure of various complex defects after radical ablation of head and neck cancers. From Oct 1991 to Feb 1992, we used forearm free flap in...
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Correction on duplicated thumbs

Cha GH, Kim KY, Choi SH, Seul JH

  • KMID: 2119250
  • J Korean Soc Plast Reconstr Surg.
  • 1992 May;19(3):492-498.
No abstract available.
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The treatment of congenital cutis aplasia

Kim YH, Cha GH, Jung JH, Lee KH, Seul JH

One case of congenital cutis aplasia is presented. The defect involved includes full-thickness skin defect of scalp and cranium. The patient was treated with debridement of dirty necrosed crust which covered...
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Immediate reconstruction of thumb tip injury

Cha GH, Woo SH, Lee DH, Seul JH

  • KMID: 1683941
  • J Korean Soc Plast Reconstr Surg.
  • 1991 May;18(3):533-538.
No abstract available.
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