- Luteolin inhibits H2O2 -induced cellular senescence via modulation of SIRT1 and p53
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Zhu RZ, Li BS, Gao SS, Seo JH, Choi BM
- KMID: 2516869
- Korean J Physiol Pharmacol.
- 2021 Jul;25(4):297-305.
- doi: 10.4196/kjpp.2021.25.4.297
Luteolin, a sort of flavonoid, has been reported to be involved in neuroprotective function via suppression of neuroinflammation. In this study, we investigated the protective effect of luteolin against oxidative... -
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- Fibroblast Growth Factor 21 Attenuates Diabetes-Induced Renal Fibrosis by Negatively Regulating TGF-β-p53-Smad2/3-Mediated Epithelial-to-Mesenchymal Transition via Activation of AKT
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Lin S, Yu L, Ni Y, He L, Weng X, Lu X, Zhang C
- KMID: 2470964
- Diabetes Metab J.
- 2020 Feb;44(1):158-172.
- doi: 10.4093/dmj.2018.0235
BACKGROUND: Epithelial-to-mesenchymal transition (EMT) is required for renal fibrosis, which is a characteristic of diabetic nephropathy (DN). Our previous study demonstrated that fibroblast growth factor 21 (FGF21) prevented DN associated... -
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- Relationship between the precursors of high grade serous ovarian cancer and patient characteristics: decreased incidence of the p53 signature in pregnant women
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Ida T, Fujiwara H, Kiriu T, Taniguchi , Kohyama A
- KMID: 2458901
- J Gynecol Oncol.
- 2019 Nov;30(6):e96.
- doi: 10.3802/jgo.2019.30.e96
OBJECTIVE: To investigate the relationship between the precursors of high grade serous ovarian cancer (HGSOC) and the characteristics of patients with a low HGSOC risk in terms of the effects... -
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- Prospective study of the efficacy and utility of TP53 mutations in circulating tumor DNA as a non-invasive biomarker of treatment response monitoring in patients with high-grade serous ovarian carcinoma
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Kim YM, Lee SW, Lee YJ, Lee HY, Lee JE, Choi EK
- KMID: 2440515
- J Gynecol Oncol.
- 2019 May;30(3):e32.
- doi: 10.3802/jgo.2019.30.e32
OBJECTIVE: Somatic TP53 mutation (TP53mut ) is a characteristic finding in high-grade serous ovarian cancer (HGSOC). The aim of this study was to assess the clinical efficacy and utility of TP53mut circulating... -
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- Retention Esophagitis as a Significant Clinical Predictor of Progression to Esophageal Cancer in Achalasia
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Kim H, Park H, Choi H, Shin Y, Park H, Youn YH, Kim JH
- KMID: 2410983
- Clin Endosc.
- 2018 Mar;51(2):161-166.
- doi: 10.5946/ce.2017.087
BACKGROUND/AIMS: Chronic liquid and/or food stasis caused by retention esophagitis (RE) in achalasia is a notable endoscopic finding because of the presence of a thickened or whitish esophageal mucosa and... -
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- Clinical Characteristics and Prognosis of Differentiated Thyroid Carcinoma with Small Foci of Anaplastic Transformation
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Ahn HY, Jung KC, Park DJ, Park YJ, Cho BY
- KMID: 2396813
- Int J Thyroidol.
- 2017 Nov;10(2):96-101.
- doi: 10.11106/ijt.2017.10.2.96
BACKGROUND AND OBJECTIVES: Anaplastic thyroid carcinoma (ATC) is commonly related with concurrent differentiated thyroid carcinoma (DTC). We aimed to examine the clinicopathologic characteristics, prognosis and gene expression of DTC with... -
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- Basaloid Squamous Cell Carcinoma of the Head and Neck: Subclassification into Basal, Ductal, and Mixed Subtypes Based on Comparison of Clinico-pathologic Features and Expression of p53, Cyclin D1, Epidermal Growth Factor Receptor, p16, and Human Papillomavirus
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Cho KJ, Jeong SU, Kim SB, Lee SW, Choi SH, Nam SY, Kim SY
- KMID: 2392577
- J Pathol Transl Med.
- 2017 Jul;51(4):374-380.
- doi: 10.4132/jptm.2017.03.03
BACKGROUND: Basaloid squamous cell carcinoma (BSCC) is a rare variant of squamous cell carcinoma with distinct pathologic characteristics. The histogenesis of BSCC is not fully understood, and the cancer has... -
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- Clinical Significance of p53 Protein Expression, Beta-catenin Expression and HER2 Expression for Epstein-Barr Virus-associated Gastric Cancer
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Baek DW, Kang BW, Hwang S, Kim JG, Seo AN, Bae HI, Kwon OK, Lee SS, Chung HY, Yu W
- KMID: 2379287
- Chonnam Med J.
- 2017 May;53(2):140-146.
- doi: 10.4068/cmj.2017.53.2.140
This study assessed the expression of the p53 protein, beta-catenin, and HER2 and their prognostic implications in patients with EBV-associated gastric cancer (EBVaGC). After reviewing 1318 consecutive cases of surgically... -
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- Inhibition of Nicotinamide Phosphoribosyltransferase Induces Apoptosis in Estrogen Receptor-Positive MCF-7 Breast Cancer Cells
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Alaee M, Khaghani S, Behroozfar K, Hesari Z, Ghorbanhosseini SS, Nourbakhsh M
- KMID: 2379395
- J Breast Cancer.
- 2017 Mar;20(1):20-26.
- doi: 10.4048/jbc.2017.20.1.20
PURPOSE: Tumor cells have increased turnover of nicotinamide adenine dinucleotide (NADâº), the main coenzyme in processes including adenosine diphosphate-ribosylation, deacetylation, and calcium mobilization. NAD⺠is predominantly synthesized in human cells... -
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- The Predictive Value of Pathologic Features in Pituitary Adenoma and Correlation with Pituitary Adenoma Recurrence
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Kim JS, Lee YS, Jung MJ, Hong YK
- KMID: 2361989
- J Pathol Transl Med.
- 2016 Nov;50(6):419-425.
- doi: 10.4132/jptm.2016.06.30
BACKGROUND: The 2004 World Health Organization classification introduced atypical pituitary adenoma (aPA), which was equivocally defined as invasion with increased mitotic activity that had a Ki-67 labeling index (LI) greater... -
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- Association between Mutation and Expression of TP53 as a Potential Prognostic Marker of Triple-Negative Breast Cancer
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Kim JY, Park K, Jung HH, Lee E, Cho EY, Lee KH, Bae SY, Lee SK, Kim SW, Lee JE, Nam SJ, Ahn JS, Im YH, Park YH
- KMID: 2356236
- Cancer Res Treat.
- 2016 Oct;48(4):1338-1350.
- doi: 10.4143/crt.2015.430
PURPOSE: TP53, the most frequently mutated gene in breast cancer, is more frequently altered in HER2-enriched and basal-like breast cancer. However, no studies have clarified the role of TP53 status... -
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- Ki-67 and p53 expression as a predictive marker for early postoperative recurrence in pancreatic head cancer
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Kim H, Park CY, Lee JH, Kim JC, Cho CK, Kim HJ
- KMID: 2167016
- Ann Surg Treat Res.
- 2015 Apr;88(4):200-207.
- doi: 10.4174/astr.2015.88.4.200
PURPOSE: This study aimed to evaluate the clinical significance of Ki-67 and p53 expressions in patients with pancreatic head cancer. METHODS: Between May 2008 and April 2013, immunohistochemical staining for Ki-67... -
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- Predictive Significance of p53, Ki-67, and Bcl-2 Expression for Pathologic Complete Response after Neoadjuvant Chemotherapy for Triple-Negative Breast Cancer
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Kim T, Han W, Kim MK, Lee JW, Kim J, Ahn SK, Lee HB, Moon HG, Lee KH, Kim TY, Han SW, Im SA, Park IA, Kim JY, Noh DY
- KMID: 2286332
- J Breast Cancer.
- 2015 Mar;18(1):16-21.
- doi: 10.4048/jbc.2015.18.1.16
PURPOSE: Patients with triple-negative breast cancer (TNBC) with pathologic complete response (pCR) to neoadjuvant chemotherapy (NAC) have superior survival outcomes compared to those with residual disease after NAC. This study... -
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- Mdm2 and p53 Expression in Radiation-Induced Sarcomas of the Head and Neck: Comparison with De Novo Sarcomas
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Song MJ, Song JS, Roh JL, Choi SH, Nam SY, Kim SY, Kim SB, Lee SW, Cho KJ
- KMID: 2381317
- Korean J Pathol.
- 2014 Oct;48(5):346-350.
- doi: 10.4132/KoreanJPathol.2014.48.5.346
BACKGROUND: The pathogenesis of radiation-induced sarcomas (RISs) is not well known. In RIS, TP53 mutations are frequent, but little is known about Mdm2-p53 interaction, which is a recent therapeutic target... -
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- Combined Antiangiogenic and Mammalian Target of Rapamycin Inhibitor Targeted Therapy in Metaplastic Breast Cancer Harboring a PIK3CA Mutation
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Agarwal R, Koenig K, Rohren E, Subbiah V
- KMID: 2286357
- J Breast Cancer.
- 2014 Sep;17(3):287-290.
- doi: 10.4048/jbc.2014.17.3.287
Metaplastic breast cancer (MpBC) is an extremely rare breast cancer subtype, characterized by a heterogeneous phenotype. MpBC aggressive biology is attributed to its stem cell-like characteristics. Since these tumors are... -
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- The Role of TWIST in Ovarian Epithelial Cancers
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Kim K, Park EY, Yoon MS, Suh DS, Kim KH, Lee JH, Shin DH, Kim JY, Sol MY, Choi KU
- KMID: 1719562
- Korean J Pathol.
- 2014 Aug;48(4):283-291.
- doi: 10.4132/KoreanJPathol.2014.48.4.283
BACKGROUND: Epithelial-mesenchymal transition (EMT) is associated with tumor hypoxia. EMT is regulated, in part, by the action of TWIST, which inhibits of E-cadherin expression and may interfere with the p53... -
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- p53 Expression in a Malignant Mesothelioma Patient during Seven-Year Follow-up
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Koo SM, Uh ST, Kim DW, Kim KU, Kim YK
- KMID: 2320518
- Tuberc Respir Dis.
- 2014 Jun;76(6):284-288.
Malignant mesothelioma (MM) is the aggressive tumor of serosal surfaces. There are crude pathogenetic results regarding the biology of MM. Coordinated upregulations of p53 gene expression are shown in malignancies.... -
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- IMP3, a Promising Prognostic Marker in Clear Cell Renal Cell Carcinoma
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Park JY, Choe M, Kang Y, Lee SS
- KMID: 1978942
- Korean J Pathol.
- 2014 Apr;48(2):108-116.
BACKGROUND: Insulin-like growth factor II mRNA-binding protein 3 (IMP3) has been reported as a prognostic biomarker in various cancers. To validate IMP3 as a prognostic biomarker in renal cell carcinoma... -
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- Distribution of Human Papillomavirus 52 and 58 Genotypes, and Their Expression of p16 and p53 in Cervical Neoplasia
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Kim TE, Kim HW, Lee KE
- KMID: 1875754
- Korean J Pathol.
- 2014 Feb;48(1):24-29.
BACKGROUND: This study investigates the prevalence of human papillomavirus (HPV) 52 and 58 genotypes among women residing in Busan, and the expression of p16 and p53 proteins in cervical neoplasia... -
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- Effect Modification of Hormonal Therapy by p53 Status in Invasive Breast Cancer
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Ahn SH, Kim HJ, Han W, Cho J, Gong G, Jung KH, Kim SB, Son BH, Lee JW
- KMID: 1976376
- J Breast Cancer.
- 2013 Dec;16(4):386-394.
- doi: 10.4048/jbc.2013.16.4.386
PURPOSE: We aimed to confirm the prognostic and predictive value of p53 expression, particularly in invasive breast cancer patients, according to immunohistochemical hormone receptor (HR) and human epidermal growth factor... -
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