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Postoperative Thrombotic Microangiopathy with the Combined Administration of Tranexamic Acid and Batroxobin: Two Case Reports

Heo MH, Kim JH, Kim JY

Thrombotic microangiopathy (TMA) is a clinical syndrome characterized by microangiopathic hemolytic anemia, thrombocytopenia, and end-organ damage. When TMA is suspected, accurate diagnosis is required; however, differential diagnosis is often difficult...
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Efficacy of Tranexamic Acid during Primary Total Knee Arthroplasty: Comparative Study between Intravenous Use and Topical Use

Lee HJ, An KY, Park JY, Chung YW

Purpose: This study examined the effectiveness of tranexamic acid in reducing postoperative blood loss in total knee arthroplasty by comparing the methods of administration between an intravenous group, topical group,...
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Advantages of Intra-Articular Tranexamic Acid Injection Following Simultaneous Bilateral Primary Total Knee Arthroplasty

Park Hs, Kim Dh, Lee Gc, Lim Jh, Lim Ds, Lee Jh

Purpose: This study examined the difference between the drainage volume, blood loss, transfusion rate, volume, and complications with or without an intra-articular (IA) tranexamic acid (TXA) injection among patients who...
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Tranexamic Acid Reduces Postoperative Blood Loss in Reverse Total Shoulder Arthroplasty

Park KY, Kim IB, Kim EY, Lee KS

Purpose: Tranexamic acid (TXA) can reduce perioperative blood loss and the frequency of blood transfusions in lower extremity surgery. On the other hand, the effects of TXA on reverse total...
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Effects of tranexamic acid on the activity of glutamate transporter EAAT3

Shin HJ, Lee SY, Na HS, Koo BW, Ryu JH, Do SH

Background: Tranexamic acid (TXA) is the most widely used hemostatic agent in surgical patients. However, when used in a high dose, it could cause a seizure in the postoperative period....
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Damage control resuscitation

Leibner E, Andreae M, Galvagno Jr SM, Scalea T

The United States Navy originally utilized the concept of damage control to describe the process of prioritizing the critical repairs needed to return a ship safely to shore during a...
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Postoperative Low-Dose Tranexamic Acid After Major Spine Surgery: A Matched Cohort Analysis

Dunn LK, Chen CJ, Taylor DG, Esfahani K, Brenner B, Luo C, Buell TJ, Spangler SN, Buchholz AL, Smith JS, Shaffrey CI, Nemergut EC, Durieux ME, Naik BI

Objective: This was a retrospective, cohort study investigating the efficacy and safety of continuous low-dose postoperative tranexamic acid (PTXA) on drain output and transfusion requirements following adult spinal deformity surgery. Methods:...
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Successful Intraoperative Management to Minimize Blood Loss Using the Combination of Tranexamic Acid and Hemocoagulase for Jehovah’s Witnesses Patient with Liver Cirrhosis

Yoo JH, Kim GT, Oh HC

A 78-year-old Jehovah’s Witnesses women with hepatitis B viral liver cirrhosis scored as Child-Pugh A was scheduled for debulking operation of peritoneal carcinomatosis due to right ovarian cancer. Despite the...
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Prospective randomized trial comparing efficacy and safety of intravenous and intra-articular tranexamic acid in total knee arthroplasty

Li MML, Kwok JYY, Chung KY, Cheung KW, Chiu KH, Chau WW, Ho KKW

Background Total knee arthroplasty (TKA) is associated with significant perioperative blood loss and postoperative allogenic blood transfusion. Tranexamic acid (TXA) reversibly blocks lysine binding sites on plasminogen molecules and inhibits plasmin...
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Neurocritical Management of Traumatic Acute Subdural Hematomas

Shin DS, Hwang SC

Acute subdural hematoma (ASDH) has been a major part of traumatic brain injury. Intracranial hypertension may be followed by ASDH and brain edema. Regardless of the complicated pathophysiology of ASDH, the...
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Use of Intraoperative Tranexamic Acid and Wound Complications in Spine Surgery: A Retrospective Cohort Study

Kramer M, Drexler M, Herman A, Kalimian T, Klassov Y, Nasser LA

Study Design: A retrospective cohort study. Purpose: This study aims to examine the effect of tranexamic acid (TXA) on postoperative wound healing in spine surgery. Overview of Literature: TXA (Cyklokapron, Hexakapron) is...
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Use of Topical Tranexamic Acid to Reduce Blood Loss in Single-Level Transforaminal Lumbar Interbody Fusion

Mallepally AR, Mahajan R, Rustagi T, Goel SA, Das K, Chhabra HS

Study Design: Nonrandomized, prospective, and case-controlled study. Purpose: To evaluate the efficacy and cost-effectiveness of topically applied tranexamic acid (TXA) during different phases of spine surgery. Overview of Literature: Perioperative blood loss...
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Blood Management Protocol without Transfusion in Orthopedic Surgery

Suh YS, Lee JJ, Nho JH, Chung H, Lee WS, Jang BW, Kim YB, Chun DI, Choi SW, Lee JC, Choi HS

We developed a new blood management protocol that allows patients to not undergo transfusion during major orthopaedic surgery. Here, we report the safety of or our protocol. The preoperative pharmacological...
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Effect of intravenous tranexamic acid on perioperative bleeding and transfusion in spine surgery: systematic review and meta-analysis of randomized controlled trials

Lee D, Choi SJ, Lee WY, Kim KM, Kim MC, Lee S

BACKGROUND: This study aimed to systematically review the literature investigating the effect of intravenous (IV) tranexamic acid (TXA) on the perioperative blood loss and amount of transfused blood in patients...
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Role of Suction Drain after Knee Arthroplasty in the Tranexamic Acid Era: A Randomized Controlled Study

Maniar RN, Pradhan P, Bhatnagar , Maniar A, Bidwai R, Bindal P

BACKGROUND: Postoperative suction drains are used after total knee arthroplasty to avoid intra-articular hematoma formation although they can increase blood loss due to a negative suction effect. The use of...
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A Randomized Controlled Trial of Topical Application of Tranexamic Acid in Patients with Thoracolumbar Spine Trauma Undergoing Long-Segment Instrumented Posterior Spinal Fusion

Sudprasert W, Tanaviriyachai T, Choovongkomol K, Jongkittanakul S, Piyapromdee U

STUDY DESIGN: Prospective, randomized controlled trial. PURPOSE: To evaluate the effect of topically applied tranexamic acid (TXA) on postoperative blood loss of neurologically intact patients with thoracolumbar spine trauma. OVERVIEW OF LITERATURE:...
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Coagulation abnormalities and bleeding in pregnancy: an anesthesiologist's perspective

Yoon HJ

During pregnancy, the procoagulant activity increases (manifested by elevation in factor VII, factor VIII, factor X, and fibrinogen levels), while the anticoagulant activity decreases (characterized by reduction in fibrinolysis and...
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Predictors of Hematoma Enlargement in Patients with Spontaneous Intracerebral Hemorrhage Treated with Rapid Administration of Antifibrinolytic Agents and Strict Conservative Management

Kim CH, Lee SW, Kim YH, Sung SK, Son DW, Song GS

OBJECTIVE: Spontaneous intracerebral hemorrhage (ICH) is caused by the rupture of small blood vessels and other health problems. In ICH patients, hematoma enlargement is the most critical risk factor for...
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Minimal Dose of Tranexamic Acid Is Effective in Reducing Blood Loss in Complex Spine Surgeries: A Randomized Double-Blind Placebo Controlled Study

Shakeri M, Salehpour , Shokouhi G, Aeinfar K, Aghazadeh , Mirzaei F, Alavi SA

STUDY DESIGN: A randomized double-blind placebo controlled study. PURPOSE: In the present study, we aimed to assess the efficacy of tranexamic acid (TXA) in reducing blood loss after laminectomy and posterolateral...
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Comparison of Blood Loss between Intra-Articular and Intravenous Tranexamic Acid Following Primary Total Knee Arthroplasty

Lee GC, Kim DH, Lee JW, Kang SW, Cho SW

PURPOSE: To investigate the difference in blood loss between two injection methods, intravenous (IV) and intra-articular (IA) methods via drain tube. MATERIALS AND METHODS: A total of 183 patients who underwent...
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