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Pathobiolgy and Management of Alzheimer’s Disease

Kim H, Chung JY

Amyloid and tau protein abnormalities have been identified as the main causes of Alzheimer’s disease but exact mechanisms remain to be revealed. Especially, amyloid beta and tau protein coupling and...
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High Serum Levels of Serum 100 Beta Protein, Neuron-specific Enolase, Tau, Active Caspase-3, M30 and M65 in Children with Autism Spectrum Disorders

Ayaydın H, Kirmit A, Çelik H, Akaltun , Koyuncu , Ulgar

Objective: The purpose of this study was therefore to investigate whether neuronal, axonal, and glial cell markers (Neuron-specific enolase [NSE], tau, serum 100 beta protein [S100B], respectively) and apoptosis markers...
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Alzheimer's Disease Diagnosis Using Misfolding Proteins in Blood

Lee H, Ugay D, Hong S, Kim Y

Alzheimer's disease (AD) is pathologically characterized by a long progressive phase of neuronal changes, including accumulation of extracellular amyloid-β (Aβ) and intracellular neurofibrillary tangles, before the onset of observable symptoms....
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Analysis of Tau Protein Expression in Predicting Pathological Complete Response to Neoadjuvant Chemotherapy in Different Molecular Subtypes of Breast Cancer

Lei C, Yang C, Xia B, Ji F, Zhang Y, Gao H, Xiong Q, Lin Y, Zhuang X, Zhang L, Zhu T, Cheng M, Yang M, Wang K

PURPOSE: Tau is a microtubule-associated protein that can be found in both normal and abnormal breast cells. Whether the expression of Tau protein can predict the response to neoadjuvant chemotherapy...
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Immunotherapy Targeting Neurodegenerative Proteinopathies: α-Synucleinopathies and Tauopathies

Shin J, Kim HJ, Jeon B

α-Synuclein and tau deposition in the central nervous system is responsible for various parkinsonian syndromes, including Parkinson’s disease, multiple system atrophy, dementia with Lewy bodies, progressive supranuclear palsy and corticobasal...
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¹⁸F-THK5351 PET Imaging in Nonfluent-Agrammatic Variant Primary Progressive Aphasia

Yoon CW, Jeong HJ, Seo S, Lee SY, Suh MK, Heo JH, Lee YB, Park KH, Okamura N, Lee KM, Noh Y

BACKGROUND AND PURPOSE: To analyze 18F-THK5351 positron emission tomography (PET) scans of patients with clinically diagnosed nonfluent/agrammatic variant primary progressive aphasia (navPPA). METHODS: Thirty-one participants, including those with Alzheimer's disease (AD,...
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Real-Time Quaking-Induced Conversion Analysis for the Diagnosis of Sporadic Creutzfeldt-Jakob Disease in Korea

Park JH, Choi YG, Lee YJ, Park SJ, Choi HS, Choi KC, Choi EK, Kim YS

BACKGROUND AND PURPOSE: The level of 14-3-3 protein in the cerebrospinal fluid (CSF) is increased in Creutzfeldt-Jakob disease (CJD) patients, which has led to it being used as a clinical...
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Diverse Molecular Targets for Therapeutic Strategies in Alzheimer's Disease

Han SH, Mook-Jung

Alzheimer's disease (AD) is the most common form of dementia caused by neurodegenerative process and is tightly related to amyloid beta (Abeta) and neurofibrillary tangles. The lack of early diagnostic...
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Regulatory B Subunits of Protein Phosphatase 2A Are Involved in Site-specific Regulation of Tau Protein Phosphorylation

Yu UY, Yoo BC, Ahn JH

Overexpression of amyloid precursor protein with the Swedish mutation causes abnormal hyperphosphorylation of the microtubule-associated protein tau. Hyperphosphorylated isoforms of tau are major components of neurofibrillary tangles, which are histopathological...
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Efficacy of the Phosphorylated tau 181 in Differential Diagnosis of the Alzheimer's Disease: A Systematic Review and Meta-Analysis

Mo JA, Jang JW, Lim JH, Lee M, Sul AR, Kim HJ, Youn YC

BACKGROUND: The purpose of this study was to evaluate the value of phosphorylated tau with epitopes threonine 181(p-tau181) in cerebrospinal fluid (CSF) for the differential diagnosis of Alzheimer's disease typed...
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Microtubule-Associated Protein Tau, alpha-Tubulin and betaIII-Tubulin Expression in Breast Cancer

Im S, Yoo C, Jung JH, Jeon YW, Suh YJ, Lee YS, Choi HJ

  • KMID: 2012154
  • Korean J Pathol.
  • 2013 Dec;47(6):534-540.
BACKGROUND: The microtubule-associated protein Tau binds to both inner and outer surfaces of microtubules, leading to tubulin assembly and microtubule stabilization. The aim of this study was to evaluate the...
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Predictive Significance of KRAS and Tau for Chemoresponse in Advanced Non-Small-Cell Lung Cancer

Yoo J, Shim BY, Yoo CY, Kang SJ, Lee KY

BACKGROUND: Taxane-platinum combinations are often used as first-line treatments for patients with advanced non-small cell lung cancer (NSCLC). Response to chemotherapy for these patients is still poor. The aim of...
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The Effect of Acetylcholine Esterase Inhibitor on Cerebrospinal Fluid beta-Amyloid 1-42 and Phosphorylated Tau Protein in Korean Alzheimer's Disease Patients: Preliminary Study

Lee EH, Youn YC, Park KY, Min JH, Kwon OS, Lee HO, Hong HJ

  • KMID: 2185066
  • J Korean Neurol Assoc.
  • 2008 Aug;26(3):224-230.
BACKGROUND: Alzheimer's disease (AD) is characterized by the pathology of amyloid plaques and tau-associated neurofibrillary tangles. Acetylcholine esterase (AChE) transforms the beta-amyloid monomer into an oligomer, and increases beta-amyloid aggregation...
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Secretin induces neurite outgrowth of PC12 through cAMP-mitogen-activated protein kinase pathway

Kim HS, Yumkham S, Kim SH, Yea K, Shin YC, Ryu SH, Suh PG

  • KMID: 1105280
  • Exp Mol Med.
  • 2006 Feb;38(1):85-93.
The gastrointestinal functions of secretin have been fairly well established. However, its function and mode of action within the nervous system remain largely unclear. To gain insight into this area,...
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Increased Expression of Phospholipase C-gamma1 Activator Protein, AHNAK in Human Lung Cancer Tissues

Oh YJ, Park CS, Choi SY, Cheong SC, Lee SM, Hwang SC, Lee YH, Hahn MH, Lee KB, Ryu HY, Bae YS, Rhee SG

  • KMID: 2318215
  • Tuberc Respir Dis.
  • 1999 Sep;47(3):347-355.
BACKGROUND: Phospholipase C(PLC) plays a central role in cellular signal transduction and is important in cellular growth, differentiation and transformation. There are currently ten known mammalian isozymes of PLC reported...
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Molecular Neurobiology of Alzheimer's Disease

Kim YH, Rhee CG, Kim YK, Kim SS

  • KMID: 2333738
  • J Korean Geriatr Psychiatry.
  • 1998 May;2(1):37-46.
Alzheimer's disease (AD), the most common dementia in the elderly, is associated with a characteristic neuropathology:extracellular neuritic plaques (NPs) and intraneuronal neurofibrillary tangles (NFTs). AD is diagnosed clinically on the...
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