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Understanding Disease Susceptibility through Population Genomics

Han S, Lee J, Kim S

Genetic epidemiology studies have established that the natural variation of gene expression profiles is heritable and has genetic bases. A number of proximal and remote DNA variations, known as expression...
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Gender Difference in Mediating Effects of Self-Efficacy for the Prevention of Sexually Transmitted Diseases (STD) among College Students' STD Knowledge, Susceptibility, and Sexual Autonomy

Park M

PURPOSE: The purpose of the study was to examine the impact of self-efficacy in the prevention of sexually transmitted diseases (STD), knowledge of and susceptibility to STD, and the role...
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Discriminant analysis of prion sequences for prediction of susceptibility

Lee JH, Bae SE, Jung S, Ahn I, Son HS

  • KMID: 2154267
  • Exp Mol Med.
  • 2013 Oct;45(10):e48.
Prion diseases, including ovine scrapie, bovine spongiform encephalopathy (BSE), human kuru and Creutzfeldt-Jakob disease (CJD), originate from a conformational change of the normal cellular prion protein (PrPC) into abnormal protease-resistant...
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Nutrition, Epigenetics, and Diseases

Jang H, Serra C

Increasing epidemiological evidence suggests that maternal nutrition and environmental exposure early in development play an important role in susceptibility to disease in later life. In addition, these disease outcomes seem...
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Susceptibility of some vertebrate hosts to infection with early third-stage larvae of Gnathostoma hispidum

Sohn WM, Lee SH

Susceptibility of some vertebrates was examined to the early third-stage larvae (EL3) of Gnathostoma hispidum. The larvae collected from the Chinese loaches were infected to 4 silk carps,...
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Association between genetic polymorphisms of the cytochromes P-450 (1A1, 2D6, and 2E1) and the susceptibility to pancreatic cancer

Lee HC, Yoon YB, Kim CY

  • KMID: 1051581
  • Korean J Intern Med.
  • 1997 Jun;12(2):128-136.
OBJECTIVES: Metabolic activation is a prerequisite for the carcinogenic effect of many carcinogens, and considerable interindividual variation exists in the metabolic capacity to activate the carcinogens. The cytochromes P-450 (CYPs)...
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Correlation between GenoType MTBDRplus Assay and Phenotypic Susceptibility Test for Prothionamide in Patients with Genotypic Isoniazid Resistance

Lee JH, Jo KW, Shim TS

BACKGROUND: The purpose of this study was to analyze the relationship between the gene mutation patterns by the GenoType MTBDRplus (MTBDRplus) assay and the phenotypic drug susceptibility test (pDST) results...
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Study on Metagonimus yokogawai(Katsurada, 1912) in Korea VII. Susceptibility of various strains of mice to Metagonimus infection and effect of Prednisolone

Chai JY, Seo BS, Lee SH

An experimental study was undertaken to observe the difference in susceptibility of mouse strains to Metagonimus yokogawai infection by estimating it from worm recovery rate and dimension of worms. It...
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Association of HLA Class II and Non-HLA Gene Polymorphisms with Disease Susceptibility in Korean Children with Type 1 Diabetes Mellitus

Jung MH, Suh BK, Kim TG, Shin CH, Lee BC

  • KMID: 1568739
  • J Korean Soc Pediatr Endocrinol.
  • 2004 Dec;9(2):136-144.
Purpose : The main genetic contribution to type 1 diabetes susceptibility is the human leukocyte antigen (HLA) class II gene. Several non-HLA chromosomal regions are also known to be involved....
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Susceptibility of Laboratory Rodents to Trichinella papuae

Sadaow L, Intapan PM, Boonmars T, Morakote N, Maleewong

Members of the genus Trichinella are small nematodes that can infect a wide range of animal hosts. However, their infectivity varies depending on the parasite and host species combination. In...
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Prevalence of ICA and anti-GAD, HLA DRB1 / DQA1 / DQB1 Polymorphism in Korean IDDM Patients

Park YS, Shin JH, Kim JB, Choi WH, Ahn YH, Kim TW, Kim MH, Yang SW, Hwang SD, Rhee HB

  • KMID: 2137374
  • J Korean Diabetes Assoc.
  • 1997 Sep;21(3):289-299.
BACKGROUND: Although the HLA class II genes are cleaily associated with insulin-dependent diabetes mellitus(IDDM) in all ethnic. Groups, considerable variation in the associated genotypes is observed among the different ethnic...
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Apolipoprotein E (APOE) Polymorphisms and Susceptibility to Breast Cancer: A Meta-Analysis

Saadat M

  • KMID: 2167597
  • Cancer Res Treat.
  • 2012 Jun;44(2):121-126.
PURPOSE: Apolipoprotein E (APOE, MIM: 107741) has three functionally distinct isoforms of the protein (E2, E3, and E4), encoded by corresponding alleles epsilon2, epsilon3, and epsilon4, which have been well...
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Sunburn Deteriorated to a Deep Second-Degree Wound in a Healthy Young Female without Risk Factors

Yoon HS, Na YC

Sunburn is the transient inflammatory response of skin caused by excessive exposure to ultraviolet radiation (UVR). The rate of disease progression varies because each individual has different levels of sunburn...
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Immunosuppressive effect of Cryptosporidium baileyi infection on vaccination against avian infectious bronchitis in chicks

Rhee JK, Yang HJ, Yook SY, Kim HC

Two-day-old commercial chicks were inoculated orally with 2 x 10(6) oocysts of Cryptosporidium baileyi and vaccinated with 10(3.5) EID50/head of a commercially available avian infectious bronchitis (IB) live virus vaccine...
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Analysis of the markers related with relapse after withdrawal of antithyroid drug in patients with Graves' disease

Kim KW, Park YJ, Lee YJ, Lee EJ, Lee EK, Park MH, Park DJ, Cho BY

  • KMID: 2256414
  • Korean J Med.
  • 2007 May;72(5):522-528.
BACKGROUND: Graves' disease is an organ-specific autoimmune disease that is characterized by thyrotoxicosis, and this is caused by TSH receptor stimulating autoantibody. Antithyroid drugs have been a mainstay of treatment...
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A Multicenter Study of Antimicrobial Susceptibility of Uropathogens Causing Acute Uncomplicated Cystitis in Woman

Lee SJ, Cho YH, Kim BW, Lee JG, Jung SI, Lee SD, Lee SE, Kim ME, Choi YD, Rim JS, Sim BS, Cho IR, Ryu SB, Kim CS, Kim WJ, Lee TY

  • KMID: 2293456
  • Korean J Urol.
  • 2003 Jul;44(7):697-701.
PURPOSE: Worldwide data shows that there is an increasing resistance among urinary tract pathogens to the first-line antimicrobial agents used in domestic areas. The objective of this study was to...
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Familial systemic lupus erythematosus in two Korean male siblings

Kang HS, Oh HJ, Kim YR, Kim JW, Shin KS

Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease characterized by the production of a wide range of autoantibodies, resulting in tissue damage. Although the susceptibility to SLE has been...
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Pathogenesis of Ankylosing Spondylitis

Hur JW, Kim TH

  • KMID: 2334810
  • J Korean Rheum Assoc.
  • 2005 Sep;12(3):163-172.
The hallmark of ankylosing spondylitis (AS) is acute and chronic spinal inflammation initiating in the sacroiliac joints, often coupled with enthesitis, presenting as chronic inflammation at the sites of ligamentous...
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Association between Lung Cancer Susceptibility Variants Identified by Genome-Wide Association Studies and the Survival of Non-Small Cell Lung Cancer

Hong MJ, Choi YY, Do SK, Jeon HS, Yoo SS, Lee WK, Lee SY, Lee J, Cha SI, Kim CH, Lee E, Park JY

PURPOSE: Nowadays, chromosomal regions containing genes associated with the risk of lung cancer are identified by a number of genome-wide association studies (GWASs). As part of the study, GWAS has...
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Intensity of infection and development of adult Clonorchis sinensis in hamsters

Chung DI, Choi DW

In an attempt to determine the susceptibility of inbred golden hamsters(Mesocricetus auratus) to the experimental infection with Clonorchis sinensis, twenty-five hamsters were divided into 5 groups and administered orally 5,...
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