- Expression of RhoA in Colorectal Cancers and Its Clinicopathological Significance
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Jung HI, Choi YY, Baek MJ, Bae SH, Bae SB, Jung DJ, Kim SY, Lee MS, Cho MS, Kim CH
- KMID: 2198862
- J Korean Soc Coloproctol.
- 2008 Dec;24(6):460-466.
- doi: 10.3393/jksc.2008.24.6.460
PURPOSE: The Rho family of GTPases are involved in actin cytoskeleton organization and are associated with carcinogenesis and progression of human cancers. The clinicopathological significance of RhoA is not yet... -
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- The proteins of synaptic vesicle membranes are affected during ageing of rat brain
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Lee SR, Kim AR, Kim JS, Kim JB, Lee JY, Lee YL, Choe M, Park JB
- KMID: 1457533
- Exp Mol Med.
- 2001 Dec;33(4):220-225.
Low molecular weight GTP-binding proteins are molecular switches that are believed to play pivotal roles in cell growth, differentiation, cytoskeletal organization, and vesicular trafficking. Rab proteins are key players in... -
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- Increased p190RhoGEF expression in activated B cells correlates with the induction of the plasma cell differentiation
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Ha YJ, Jeong JH, Park Y, Lee JR
- KMID: 1120132
- Exp Mol Med.
- 2012 Feb;44(2):138-148.
- doi: 10.3858/emm.2012.44.2.009
Previously, we demonstrated that the p190 Rho guanine nucleotide exchange factor (p190RhoGEF) was induced following CD40 stimulation of B cells. In this study, we examined whether p190RhoGEF and a downstream... -
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- Changes in Myogenic Tone in Spontaneously Hypertensive Rat: Role of RhoA and Protein Kinase C
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Seo JP, Ryu SK, Kang NY, Ahn DS, Lee YH
- KMID: 1938907
- Korean Circ J.
- 2002 Mar;32(3):257-267.
- doi: 10.4070/kcj.2002.32.3.257
BACKGROUND AND OBJECTIVES: The myogenic response was originally described as a contraction of a blood vessel that occurred following an increase in intravascular distending pressure. Conversely, a reduction in intravascular... -
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- Phosphorylation of phospholipase D1 and the modulation of its interaction with RhoA by cAMP-dependent protein kinase
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Jang MJ, Lee MJ, Park HY, Bae YS, Min DS, Ryu SH, Kwak JY
- KMID: 1380212
- Exp Mol Med.
- 2004 Apr;36(2):172-178.
Agents that elevate cellular cAMP are known to inhibit the activation of phospholipase D (PLD). We investigated whether PLD can be phosphorylated by cAMP-dependent protein kinase (PKA) and PKA-mediated phosphorylation... -
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- MLCK and PKC Involvements via Gi and Rho A Protein in Contraction by the Electrical Field Stimulation in Feline Esophageal Smooth Muscle
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Park SY, Shim JH, Kim M, Sun YH, Kwak HS, Yan X, Choi BC, Im C, Sim SS, Jeong JH, Kim IK, Min YS, Sohn UD
- KMID: 1457698
- Korean J Physiol Pharmacol.
- 2010 Feb;14(1):29-35.
- doi: 10.4196/kjpp.2010.14.1.29
We have shown that myosin light chain kinase (MLCK) was required for the off-contraction in response to the electrical field stimulation (EFS) of feline esophageal smooth muscle. In this study,... -
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- Effects of Rho Kinase Inhibitor on Detrusor Overactivity after Bladder Outlet Obstruction in Rats
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Kim HW, Cho SY, Park DJ, Yoon BI, Lee JY
- KMID: 2061277
- Korean J Urol.
- 2007 Aug;48(8):832-837.
- doi: 10.4111/kju.2007.48.8.832
PURPOSE: A partial bladder outlet obstruction(PBOO) related detrusor hypertrophy is associated with up-regulation of the Rho kinase activity in an experimental animal model, and has been implicated in PBOO induced... -
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- Downstream components of RhoA required for signal pathway of superoxide formation during phagocytosis of serum opsonized zymosans in macrophages
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Kim JS, Kim JG, Jeon CY, Won HY, Moon MY, Seo JY, Kim JI, Kim J, Lee JY, Choi SY, Park J, Yoon Park , Ha KS, Kim PH, Park JB
- KMID: 1116203
- Exp Mol Med.
- 2005 Dec;37(6):575-587.
Rac1 and Rac2 are essential for the control of oxidative burst catalyzed by NADPH oxidase. It was also documented that Rho is associated with the superoxide burst reaction during phagocytosis... -
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- Role of LPA and the Hippo pathway on apoptosis in salivary gland epithelial cells
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Hwang SM, Jin M, Shin YH, Ki Choi S, Namkoong E, Kim M, Park MY, Park K
- KMID: 2155390
- Exp Mol Med.
- 2014 Dec;46(12):e125.
- doi: 10.1038/emm.2014.77
Lysophosphatidic acid (LPA) is a bioactive lysophospholipid involved in numerous physiological responses. However, the expression of LPA receptors and the role of the Hippo signaling pathway in epithelial cells have... -
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- Simvastatin inhibits sphingosylphosphorylcholine-induced differentiation of human mesenchymal stem cells into smooth muscle cells
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Kim KH, Kim YM, Lee MJ, Ko HC, Kim MB, Kim JH
- KMID: 1120134
- Exp Mol Med.
- 2012 Feb;44(2):159-166.
- doi: 10.3858/emm.2012.44.2.011
Sphingosylphosphorylcholine (SPC) induces differentiation of human adipose tissue-derived mesenchymal stem cells (hASCs) into smooth muscle-like cells expressing alpha-smooth muscle actin (alpha-SMA) via transforming growth factor-beta1/Smad2- and RhoA/Rho kinase-dependent mechanisms. 3-Hydroxy-3-methylglutaryl-coenzyme... -
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- AMPA, not NMDA, activates RhoA GTPases and subsequetly phosphorylates moesin
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Kim SJ, Jeon S, Shin EY, Kim EG, Park J, Bae CD
- KMID: 755672
- Exp Mol Med.
- 2004 Feb;36(1):98-102.
Glutamate induced rapid phosphorylation of moesin, one of ERM family proteins involved in the ligation of membrane to actin cytoskeleton, in rat hippocampal cells (JBC, 277:16576-16584, 2002). However, the identity... -
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