- Activation of small Rho GTPases by blebbistatin in PC12 cells
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Kim EG, Shin EY
- KMID: 1498922
- J Biomed Res.
- 2013 Jun;14(2):60-64.
Neuronal differentiation is a complex biological process accompanying cytoskeletal reorganization, including neurite outgrowth and growth cone formation. Therefore, neuronal differentiation is critically regulated by actin-related signaling proteins, such as small... -
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- Current concepts of the podocyte in nephrotic syndrome
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Ding WY, Saleem MA
- KMID: 1441573
- Kidney Res Clin Pract.
- 2012 Jun;31(2):87-93.
Nephrotic syndrome is a disorder of the glomerular filtration barrier, and central to the filtration mechanism of the glomerular filtration barrier is the podocyte. We are starting to better understand... -
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- Prevention of Vasculogenic Erectile Dysfunction in Rat Model by the Chronic Administration of Oral Rho Kinase Inhibitor
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Park K, Park MY, Kim SW, Paick JS
- KMID: 2294182
- Korean J Urol.
- 2006 Mar;47(3):322-330.
- doi: 10.4111/kju.2006.47.3.322
PURPOSE: Since Rho-Rho kinase calcium sensitizing pathway is being regarded as a potential target not only for the treatment of erectile dysfunction but also atherosclerosis, we designed a study to... -
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- R1467H Variants of Rho Guanine Nucleotide Exchange Factor 11 (ARHGEF11) are Associated with Type 2 Diabetes Mellitus in Koreans
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Jin QS, Kim SH, Piao SJ, Lim HA, Lee SY, Hong SB, Kim YS, Lee HJ, Nam M
- KMID: 2222364
- Korean Diabetes J.
- 2010 Dec;34(6):368-373.
- doi: 10.4093/kdj.2010.34.6.368
BACKGROUND: The human Rho guanine nucleotide exchange factor 11 (ARHGEF11) functions as an activator of Rho GTPases and is thought to influence insulin signaling. The R1467H variant of ARHGEF11 has... -
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- p21-activated kinase 1 is allostericallyInhibited by naphthoquinone (NQ) derivatives
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Oh SW, Lee KI, Choi JK, Kim KA, Kim EG, Shin EY
- KMID: 2394586
- J Biomed Transl Res.
- 2017 Jun;18(2):43-49.
- doi: 10.12729/jbtr.2017.18.2.043
The p21-activated kinases (PAKs) are a family of serine/threonine protein kinases and activated by binding with activated Rho GTPases such as Rac or Cdc42. PAKs regulate actin cytoskeletal remodeling, cell... -
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- Small molecules that allosterically inhibit p21-activated kinase activity by binding to the regulatory p21-binding domain
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Kim DJ, Choi CK, Lee CS, Park MH, Tian X, Kim ND, Lee KI, Choi JK, Ahn JH, Shin EY, Shin I, Kim EG
- KMID: 2361516
- Exp Mol Med.
- 2016 Apr;48(4):e229.
- doi: 10.1038/emm.2016.13
p21-activated kinases (PAKs) are key regulators of actin dynamics, cell proliferation and cell survival. Deregulation of PAK activity contributes to the pathogenesis of various human diseases, including cancer and neurological... -
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- The role of Rho GTPases in the regulation of the rearrangement of actin cytoskeleton and cell movement
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Begum R, Nur-E-Kamal MSA, Zaman MA
- KMID: 1094080
- Exp Mol Med.
- 2004 Aug;36(4):358-366.
The rearrangement of the actin cytoskeleton has been shown to play a critical role in the development of transformation and malignant phenotype of cancer cells. Rho family GTPases regulate the... -
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- D4-GDI is cleaved by caspase-3 during daunorubicin-induced apoptosis in HL-60 cells
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Kwon KB, Park EK, Ryu DG, Park BH
- KMID: 1093595
- Exp Mol Med.
- 2002 Mar;34(1):32-37.
Daunorubicin, an anti-cancer drug, is known to induce apoptosis in HL-60 cells in a dose-dependent manner through the activation of caspase-3 (CPP32). Caspase-3 selective inhibitor, Ac-DEVD-CHO, prevented both the activation... -
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