- Selective Inhibition of PI3K Isoforms in Brain Tumors Suppresses Tumor Growth by Increasing Radiosensitivity
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Seol MY, Choi SH, Lee IJ, Park HS, Kim HR, Kim SK, Yoon HI
- KMID: 2538964
- Yonsei Med J.
- 2023 Feb;64(2):139-147.
- doi: 10.3349/ymj.2022.0414
Purpose: Glioblastoma (GBM) is a malignant brain tumor with poor prognosis. Radioresistance is a major challenge in the treatment of brain tumors. The development of several types of tumors, including... -
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- Increased Radiosensitivity of Solid Tumors Harboring ATM and BRCA1/2 Mutations
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Kim KH, Kim HS, Kim Ss, Shim HS, Yang AJ, Lee JJB, Yoon HI, Ahn JB, Chang JS
- KMID: 2524587
- Cancer Res Treat.
- 2022 Jan;54(1):54-64.
- doi: 10.4143/crt.2020.1247
Purpose Preclinical data indicate that response to radiotherapy (RT) depends on DNA damage repair. In this study, we investigated the role of mutations in genes related to DNA damage repair in... -
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- A Radiosensitivity Gene Signature and PD-L1 Status Predict ClinicalOutcome of Patients with Glioblastoma Multiforme in The CancerGenome Atlas Dataset
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Jang BS, Kim IA
- KMID: 2500338
- Cancer Res Treat.
- 2020 Apr;52(2):530-542.
- doi: 10.4143/crt.2019.440
Purpose Combination of radiotherapy and immune checkpoint blockade such as programmed death- 1 (PD-1) or programmed death-ligand 1 (PD-L1) blockade is being actively tested in clinical trial. We aimed to identify a subset... -
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- Disulfiram, a Re-positioned Aldehyde Dehydrogenase Inhibitor, Enhances Radiosensitivity of Human Glioblastoma Cells In Vitro
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Koh HK, Seo SY, Kim JH, Kim HJ, Chie EK, Kim SK, Kim IH
- KMID: 2464415
- Cancer Res Treat.
- 2019 Apr;51(2):696-705.
- doi: 10.4143/crt.2018.249
PURPOSE: Glioblastoma, the most common brain tumor in adults, has poor prognosis. The purpose of this study was to determine the effect of disulfiram (DSF), an aldehyde dehydrogenase inhibitor, on... -
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- Longitudinal Assessment of Intravoxel Incoherent Motion Diffusion Weighted Imaging in Evaluating the Radio-sensitivity of Nasopharyngeal Carcinoma Treated with Intensity-Modulated Radiation Therapy
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Xiao Y, Chen Y, Chen Y, He Z, Yao Y, Pan J
- KMID: 2437625
- Cancer Res Treat.
- 2019 Jan;51(1):345-356.
- doi: 10.4143/crt.2018.089
PURPOSE: Intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI)was evaluated regarding its ability to preliminarily predict the short-term treatment response of nasopharyngeal carcinoma (NPC) following intensity-modulated radiation therapy. MATERIALS AND METHODS: IVIM-DWI with... -
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- DNA Methyltransferase Gene Polymorphisms for Prediction of Radiation-Induced Skin Fibrosis after Treatment of Breast Cancer: A Multifactorial Genetic Approach
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Terrazzino S, Deantonio , Cargnin S, Donis L, Pisani C, Masini L, Gambaro G, Canonico P, Genazzani , Krengli M
- KMID: 2378119
- Cancer Res Treat.
- 2017 Apr;49(2):464-472.
- doi: 10.4143/crt.2016.256
PURPOSE: This study was conducted to investigate the role of four polymorphic variants of DNA methyltransferase genes as risk factors for radiation-induced fibrosis in breast cancer patients. We also assessed... -
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- Phospholipase D inhibitor enhances radiosensitivity of breast cancer cells
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Son JC, Kang DW, Yang KM, Choi KY, Son TG, Min DS
- KMID: 2154257
- Exp Mol Med.
- 2013 Aug;45(8):e38.
Radiation and drug resistance remain the major challenges and causes of mortality in the treatment of locally advanced, recurrent and metastatic breast cancer. Dysregulation of phospholipase D (PLD) has been... -
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- Enhancement of radiation effect using beta-lapachone and underlying mechanism
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Ahn KJ, Lee HS, Bai SK, Song CW
- KMID: 2051119
- Radiat Oncol J.
- 2013 Jun;31(2):57-65.
- doi: 10.3857/roj.2013.31.2.57
Beta-lapachone (beta-Lap; 3,4-dihydro-2, 2-dimethyl-2H-naphthol[1, 2-b]pyran-5,6-dione) is a novel anti-cancer drug under phase I/II clinical trials. beta-Lap has been demonstrated to cause apoptotic and necrotic death in a variety of human... -
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- The Use of MTT Assay, In Vitro and Ex Vivo, to Predict the adiosensitivity of Colorectal Cancer
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Kim JE, Kim MS, Kang CM, Kim JI, Shin HK, Choi CW, Seo YS, Ji YH
- KMID: 1326643
- J Korean Soc Ther Radiol Oncol.
- 2008 Sep;26(3):166-172.
- doi: 10.3857/jkstro.2008.26.3.166
PURPOSE: The measurement of radiosensitivity of individuals is useful in radiation therapy. Unfortunately, the measurement of radiation survival using a clonogenic assay, which is the established standard, can be difficult... -
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- Palliative Radiotherapy in a Patient with Pulmonary Adenoid Cystic Carcinoma
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Kim BK
- KMID: 2166025
- Cancer Res Treat.
- 2007 Dec;39(4):185-188.
Primary adenoid cystic carcinoma in the lung is very rare, so its clinicopathologic characteristics have usually been extrapolated from the salivary disease. However, the clinical courses of pulmonary adenoid cystic... -
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- Biological Markers as Predictors of Radiosensitivity in Syngeneic Murine Tumors
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Chang SK, Seong J, Kim SH, Shin HS
- KMID: 2323580
- J Korean Soc Ther Radiol Oncol.
- 2006 Jun;24(2):128-137.
PURPOSE: We investigated whether a relationship exists between tumor control dose 50 (TCD50) or tumor growth delay (TGD) and radiation induced apoptosis (RIA) in syngeneic murine tumors. Also we investigated... -
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- Antiproliferative Effect of NS-398, a Cyclooxygenase-2 Inhibitor, in Pancreatic Cancer Cell Lines.
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Lee HD, Park JW, Choi JW, Kang H, Jin GB, Choi SM, Park SS, Jang LC
- KMID: 2244243
- Korean J Hepatobiliary Pancreat Surg.
- 2006 Mar;10(1):10-20.
PURPOSE: Selective cyclooxygenase (COX)-2 inhibitors have been reported to inhibit cancer cell proliferation. We investigated the effects of NS-398, a selective COX-2 inhibitor, on cell proliferation in human pancreatic cancer... -
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- Increased Catalase Activity by All-trans Retinoic Acid and Its Effect on Radiosensitivity in Rat Glioma Cells
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Jin H, Jeon HY, Park WY, Kim WD, Ahn HY, Yu JR
- KMID: 2323930
- J Korean Soc Ther Radiol Oncol.
- 2005 Dec;23(4):211-216.
PURPOSE: It has been reported that all-trans retinoic acid (ATRA) can inhibit glioma growing in vitro. However, clinical trials with ATRA alone in gliomas revealed modest results. ATRA has been... -
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- Enhancement of radiosensitivity by combined ceramide and dimethylsphingosine treatment in lung cancer cells
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Park HW, Song JY, Kim KS, Han Y, Kim CW, Yi SY, Yun YS
- KMID: 1123762
- Exp Mol Med.
- 2004 Oct;36(5):411-419.
Ceramide generated from sphingomyelin in response to ionizing radiation has been implicated as a second messenger to induce cellular proapoptotic signals. Both ceramide and its metabolic inhibitor, N, N-dimethyl-D-erythro-sphingosine (DMS),... -
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- The Expression of Hypoxia Inducible Factor-1alpha by Desferrioxamine Induces Radioresistance in Mouse Hepatoma Cell Line
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Kwon BH
- KMID: 1516698
- J Korean Soc Ther Radiol Oncol.
- 2004 Sep;22(3):217-224.
PURPOSE: It is well known that the radiosensitivity of tumor cells can be significantly reduced under hypoxic conditions. Hypoxia-inducible factor-1alpha (HIF-1alpha) plays a pivotal role in the essential adaptive responses... -
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- Effect of irradiation on cell cycle, cell death and expression of its related proteins in normal human oral keratinocytes
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Kang MA, Heo MS, Lee SS, Oh SO, Lee SM, Jeon IS, Choi SC, Park TW
- KMID: 1873584
- Korean J Oral Maxillofac Radiol.
- 2003 Sep;33(3):143-149.
PURPOSE: To investigate the radiosensitivity of the normal human oral keratinocytes (NHOK), and the effect of irradiation on cell cycle and protein expression. MATERIALS AND METHODS: To evaluate the radiosensitivity... -
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- Effects of Sense and Antisense Expression of Protein Kinase Calpha on the Proliferation and Radiosensitization of U-87 Human Glioblastoma Cells
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Park HK, Lee KJ, Choi CR, Cho KK, Rha HK, Park SC, Cho JK, Kang JK
- KMID: 1904663
- J Korean Neurosurg Soc.
- 2002 May;31(5):469-476.
OBJECTIVE: It has been suggested that protein kinase C(PKC) may be one of a number of important regulatory enzymes influencing the tumor cell proliferation and intracellular sensitivity to irradiation. In... -
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- Experimental Study on the Radiosensitivity and Chemosensitivity of A-431 Cell Line
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Hong SW, Choi ES, Koh KJ
- KMID: 1999534
- J Korean Acad Oral Maxillofac Radiol.
- 1999 Feb;29(1):327-339.
OBJECTIVES: The purpose of this study was to aid in the prediction of tumor cell tolerance to radiotherapy and/or chemotherapy. MATERIALS AND METHODS: Human epidermoid carcinoma A-431 cell... -
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- Correlation Between the Parameters of Radiosensitivity in Human Cancer Cell Lines
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Park WY, Kim WD, Min KS
- KMID: 1840633
- J Korean Soc Ther Radiol Oncol.
- 1998 Jun;16(2):99-106.
PURPOSE: We conducted clonogenic assay using human cancer cell lines (MKN-45, PC-14, Y-79, HeLa) to investigate a correlation between the parameters of radiosensitivity. MATERIALS AND METHODS: Human cancer cell lines... -
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- Radiation Induced G2 Chromatic Break and Repairs Kinetics in Human Lymphoblastoid Cells
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Seong J
- KMID: 2097427
- J Korean Soc Ther Radiol.
- 1993 Dec;11(2):193-204.
In understanding radiosensitivity a new concept of inherent radiosensitivity based on individuality and heterogeneity within a population has recently beer explored. There has been some discussion of possible mechanism underlying... -
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