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Proton Pump Inhibitors and Gastric Cancer

Kang S, Cho SJ

Concerns have been raised regarding the long-term use of proton pump inhibitors (PPIs) as an important risk factor for gastric cancer in clinical practice. PPIs can cause hypergastrinemia at clinical...
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Proton Pump Inhibitor-Related Gastric Mucosal Changes

Kim GH

Proton pump inhibitors (PPIs) are used worldwide to treat of acid-related disorders such as peptic ulcer and gastroesophageal reflux disease and to prevent gastroduodenal injuries due to nonsteroidal anti-inflammatory drugs....
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Efficacy of Seven-Day Potassium-Competitive Acid Blocker-Based First-Line Helicobacter pylori Eradication Therapy Administered with Bismuth

Kim JY, Lee SY, Kim H, Kim JH, Sung IK, Park HS

Purpose: To determine the efficacy of a potassium-competitive acid blocker (P-CAB)-based first-line eradication therapy with bismuth compared with that of proton pump inhibitor-based first-line therapy with bismuth. Materials and Methods: Eradication-naive...
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Evaluations of Gastric Acid Pocket Using Novel Vertical 8-Channel pH Monitoring System and Effects of Acid Secretion Inhibitors

Sumi S, Ishimura N, Mikami H, Okimoto E, Tamagawa Y, Mishiro T, Kinoshita Y, Ishihara S

  • KMID: 2517531
  • J Neurogastroenterol Motil.
  • 2021 Jul;27(3):370-376.
  • doi: 10.5056/jnm20115
Background/Aims The gastric acid pocket has an important role in gastroesophageal reflux disease development. In this study, we utilized a novel 8-channel pH monitoring system with sensor intervals of 1 cm...
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Proton-pump Inhibitors and the Risk of Dementia: A Systematic Review and Meta-analysis

Yoon KT, Bang CS, Kim JS

Background/Aims: Proton pump inhibitors (PPIs) are widely used to treat several acid-related gastrointestinal disorders. This study aimed to investigate the risk of dementia in patients taking PPIs. Materials and Methods: A...
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A Systematic Review and Meta-analysis of Randomized Control Trials: Combination Treatment With Proton Pump Inhibitor Plus Prokinetic for Gastroesophageal Reflux Disease

Jung DH, Huh CW, Lee SK, Park JC, Shin SK, Lee YC

  • KMID: 2514673
  • J Neurogastroenterol Motil.
  • 2021 Apr;27(2):165-175.
  • doi: 10.5056/jnm20161
Background/Aims Prokinetics can be used for treating patients with gastroesophageal reflux disease (GERD), who exhibit suboptimal response to proton pump inhibitor (PPI) treatment. We conducted a systematic review to assess the...
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Analysis for Risk Factors and Effect of Vocal Hygiene Education in Patients of Vocal Polyp

Choi N, Kim DG, Lee G

Background and Objectives Vocal polyp is one of the most common benign diseases of vocal fold caused by overuse of voice. Laryngeal microsurgery is the first treatment of choice for...
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Clinical Practice Guidelines for the Treatment of Functional Dyspepsia in Korea

Oh JH, Kwon JG, Jung HK, Tae CH, Song KH, Kang SJ, Kim SE, Jung K, Kim JS, Park JK, Bang KB, Shin JE, Baeg MK, Shin CM, Lee JY, Lim HC, FDRGaCPGGUtKS

Background/Aims: Functional dyspepsia (FD) is a chronic upper gastrointestinal symptom complex that routine diagnostic work-up, such as endoscopy, blood laboratory analysis, or radiological examination, fails to identify a cause for....
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Effect of acid-reducing agents on clinical relapse in ulcerative colitis with pH-dependent-released 5-aminosalicylic acid: a multicenter retrospective study in Japan

Shimodaira Y, Onochi K, Watanabe K, Takahashi S, Fukuda S, Watanabe N, Koizumi S, Matsuhashi T, Iijima K

Background/Aims: 5-Aminosalicylic acid (5-ASA) is a basic drug for inducing and maintaining remission for ulcerative colitis. One of its formulations has a coating with a pH-dependent degradation that ensures the...
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Proton Pump Inhibitor Use Increases Pyogenic Liver Abscess Risk: A Nationwide Cohort Study

Oh JH, Kang D, Kang W, Guallar E, Cho J, Min YW

  • KMID: 2521156
  • J Neurogastroenterol Motil.
  • 2021 Oct;27(4):555-564.
  • doi: 10.5056/jnm20221
Background/Aims Proton pump inhibitors (PPIs) increase gastric pH and alter the gut microbiome. An increased risk for infectious diseases has been reported in PPI users. However, little is known about the...
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Esophageal Nocturnal Baseline Impedance and Post-reflux Swallow-induced Peristaltic Wave Index in Identifying Proton Pump Inhibitor-refractory Non-erosive Reflux Disease

Wang Y, Ye B, Wang M, Lin L, Jiang L

  • KMID: 2521152
  • J Neurogastroenterol Motil.
  • 2021 Oct;27(4):525-532.
  • doi: 10.5056/jnm20073
Background/Aims Esophageal mean nocturnal baseline impedance (MNBI) levels and post-reflux swallow-induced peristaltic wave (PSPW) index could increase the diagnostic value of 24-hour multichannel intraluminal impedance and pH monitoring in patients with...
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Practice Patterns for Eosinophilic Esophagitis Patients in Busan and Gyeongnam: A Korean Multicenter Database Study

Kim SJ, Park MI, Kim GH, Lee MW, Jung K, Lee J, Seol SY, Jee SR, Lee HS, Jang JS, Cha JH, Busan, Ulsan, Gyeongnam Society of Neurogastroenterology and Motility

  • KMID: 2510064
  • J Neurogastroenterol Motil.
  • 2021 Jan;27(1):71-77.
  • doi: 10.5056/jnm20069
Background/Aims The prevalence of eosinophilic esophagitis is increasing in Korea and there are few single-center studies regarding eosinophilic esophagitis in Korea. In particular, data about management for eosinophilic esophagitis are lacking....
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Acid Exposure Time > 6% Might Not Improve the Therapeutic Outcome in Chinese Gastroesophageal Reflux Disease Patients

Lin Y, Li Y, Liang M, Tan N, Zhang M, Chen S, Xiao Y

  • KMID: 2510062
  • J Neurogastroenterol Motil.
  • 2021 Jan;27(1):55-62.
  • doi: 10.5056/jnm19219
Background/Aims There is less acid burden in Chinese gastroesophageal reflux disease (GERD) patients. However, the Lyon consensus proposed a higher threshold of acid exposure time (AET > 6%) for GERD. The...
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Efficacy of Seven-day High-dose Esomeprazole-based Triple Therapy versus Seven-day Standard Dose Non-esomeprazole-based Triple Therapy as the First-line Treatment of Patients with Helicobacter pylori Infection

Lee YD, Kim SE, Park SJ, Park MI, Moon W, Kim JH, Jung K, Song J

Background/Aims: The rates of Helicobacter pylori (H. pylori) eradication have declined with the use of proton pump inhibitor-amoxicillin-clarithromycin as the first-line triple therapy. On the other hand, several studies have...
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Proton pump inhibitor use is associated with hip fracture development: a nationwide populationbased cohort study

Min YW, Lee YC, Kim K, Ryu S, Hong KS, Jeon H, Kim YS, Park JH, Son HJ, Rhee PL

Background/Aims: Effect of proton pump inhibitor (PPI) use on the risk of hip fracture is controversial. This study aimed to clarify the association between PPI use and hip fracture risk using a...
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Clinical Significance of Changes in Gut Microbiome Associated with Use of Proton Pump Inhibitors

Kim TJ, Lee H

Proton pump inhibitors (PPIs) are commonly used for the treatment of gastric acid-related disorders, and are generally well tolerated. However, by reducing the secretion of gastric acid in the long...
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Eosinophilic Esophagitis with Angina Pectoris

Son MY, Kim SE, Park SJ, Park MI, Moon W, Kim JH, Jung K, Choi GS, Im SI

Eosinophilic esophagitis (EoE) is an immune or antigen-mediated chronic inflammatory esophageal disorder that is relatively rarein Asian countries. The main symptoms of EoE are dysphagia and food impaction. Although chest...
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The Lyon Consensus: Does It Differ From the Previous Ones?

Ghisa M, Barberio B, Savarino V, Marabotto E, Ribolsi M, Bodini G, Zingone F, Frazzoni M, Savarino E

  • KMID: 2503999
  • J Neurogastroenterol Motil.
  • 2020 Jul;26(3):311-321.
  • doi: 10.5056/jnm20046
Gastroesophageal reflux disease (GERD) is a complex disorder with heterogeneous symptoms and a multifaceted pathogenetic basis, which prevent a simple diagnostic algorithm or any categorical classification. Clinical history, questionnaires and...
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Therapeutic Response to 20 mg of Esomeprazole Twice Daily in Patients with Gastroesophageal Reflux Disease-related Non-cardiac Chest Pain: An Open-Label Randomized Pilot Study

Choi JK, Shim HI, Shin CM, Yoon H, Park YS, Kim N, Lee DH

Background/Aims: Non-cardiac chest pain (NCCP) is defined as recurrent angina pectoris-like pain without evidence of coronary heart disease, and is usually related to esophageal diseases, such as gastroesophageal reflux disease...
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Proton Pump Inhibitor Switching Strategy after Failure of Standard Triple Therapy for Helicobacter pylori Infection

Kim J, Kim YJ, Chung WC

Background/Aims: It is still unknown whether cytochrome P450 (CYP) 2C19 polymorphisms influence Helicobacter pylori (H. pylori) eradication, especially in eastern Asia. We aimed to evaluate how changes in proton pump...
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