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Echinococcus granulosus Protoscolex DM9 Protein Shows High Potential for Serodiagnosis of Alveolar Echinococcosis

Kim JG, Han X, Kong Y

Alveolar echinococcosis (AE) caused by infection with E. multilocularis metacestode, represents one of the most fatal helminthic diseases. AE is principally manifested with infiltrative, proliferating hepatic mass, resembling primary hepatocellular...
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Proteomic Signature of Nucleus Pulposus in Fetal Intervertebral Disc

Rajasekaran S, Soundararajan DCR, Tangavel C, K. S. SVA, Nayagam SM, Matchado MS, Muthurajan R, Shetty AP, Kanna RM, Dharmalingam K

Study Design: Profiling proteins expressed in the nucleus pulposus of fetal intervertebral disc (IVD). Purpose: To evaluate the molecular complexity of fetal IVDs not exposed to mechanical, traumatic, inflammatory, or infective...
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Proteomic Signatures of Healthy Intervertebral Discs From Organ Donors: A Comparison With Previous Studies on Discs From Scoliosis, Animals, and Trauma

Rajasekaran S, Tangavel C, Soundararajan DCR, Nayagam SM, Matchado MS, Muthurajan R, Anand KSV, Rajendran S, Shetty AP, Kanna RM, Kuppamuthu D

Objective: To catalog and characterize the proteome of normal human intervertebral disc (IVD). Methods: Nine magnetic resonance imaging (MRI) normal IVDs were harvested from 9 different brain dead yet alive voluntary...
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Pioglitazone Alters the Proteomes of Normal Bladder Epithelial Cells but Shows No Tumorigenic Effects

Shahid M, Kim M, Yeon A, Jin P, Kim WK, You S, Kim J

Purpose: Pioglitazone, an antihyperglycemic drug, is widely used in diabetes mellitus patients with insulin resistance. Although pioglitazone is known to have a potential link to bladder cancer (BC), there have...
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Proteomic Classification and Identification of Proteins Related to Tissue Healing of Platelet-Rich Plasma

Lee HW, Choi KH, Kim JY, Kim KO, Haotian B, Yuxuan L, Noh KC

BACKGROUND: Platelet-rich plasma (PRP) is a plasma component of autologous blood containing a high concentration of platelets. PRP is used to promote healing of damaged tissues. However, there are not...
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Advances in Serological Diagnosis of Taenia solium Neurocysticercosis in Korea

Ahn CS, Kim JG, Huh S, Kang I, Kong Y

Cysticercosis, a parasitic disease caused by Taenia solium metacestode (TsM), has a major global public health impact in terms of disability-adjusted life years. The parasite preferentially infects subcutaneous tissue, but...
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Proteomic Analysis of Coprinopsis cinerea under Conditions of Horizontal and Perpendicular Gravity

Kim JS, Kwon YS, Bae DW, Kwak YS, Kwack YB

Coprinopsis cinerea was employed to investigate the fungal response to gravity. Mycelium growth revealed a consistent growth pattern, irrespective of the direction of gravity (i.e., horizontal vs. perpendicular). However, the...
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Comparative proteomic analysis of proteins expression changes in the mammary tissue of cows infected with Escherichia coli mastitis

Zhao XW, Yang YX, Huang DW, Cheng GL, Zhao HL

Cows infected with Escherichia (E.) coli usually experience severe clinical symptoms, including damage to mammary tissues, reduced milk yield, and altered milk composition. In order to investigate the host response...
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Moyamoya Biomarkers

Smith ER

Moyamoya disease (MMD) is an arteriopathy of the intracranial circulation predominantly affecting the branches of the internal carotid arteries. Heterogeneity in presentation, progression and response to therapy has prompted intense...
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Proteomic analysis of pancreas in miniature pigs according to developmental stages using two-dimensional electrophoresis and matrix-assisted laser desorption/ionization-time of flight mass spectrometry

Yi SS, Kim IY, Oh SJ, Yeom HJ, Yeom SC, Hwang SY, Seong JK

  • KMID: 2312113
  • Lab Anim Res.
  • 2014 Mar;30(1):1-7.
Organ transplantation is limited by the shortage of human organs. Many studies have sought to overcome this hurdle by using animal organs. Porcine organs, especially from miniature pigs, have been...
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hpvPDB: An Online Proteome Reserve for Human Papillomavirus

Kumar S, Jena L, Daf S, Mohod K, Goyal P, Varma AK

Human papillomavirus (HPV) infection is the leading cause of cancer mortality among women worldwide. The molecular understanding of HPV proteins has significant connotation for understanding their intrusion in the host...
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Proteomic analysis of liver in miniature pigs according to developmental stages using two-dimensional electrophoresis and matrix-assisted laser desorption/ionization-time of flight mass spectrometry

Yi SS, Oh SJ, Kim IY, Yeom HJ, Yeom SC, Hwang SY, Seong JK

  • KMID: 2312109
  • Lab Anim Res.
  • 2013 Sep;29(3):162-167.
Due to the shortage of human organ donors for transplant, various studies of xenotransplantation, or the use of animal organs instead of human organs, have been carried out. The organs...
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Differentially expressed proteins in the liver of Gulo-/- mice following treatments with Helicobacter pylori and diethylnitrosamine

Nagappan A, Park HS, Park KI, Kim JA, Hong GE, Yumnam S, Kim EH, Lee WS, Lee WJ, Cho MJ, Lee WK, Won CK, Kim GS

  • KMID: 1498928
  • J Biomed Res.
  • 2013 Jun;14(2):99-104.
Vitamin C (ascorbic acid) is an essential nutrient of most living tissues. We established a strain of Gulo-/- mice with known deficiency, in which vitamin C intake can be controlled...
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Proteomic Analysis of Thiol-active Proteins of Helicobacter pylori 26695

Park JW, Song JY, Hwang HR, Park HJ, Youn HS, Seo JH, Kang HL, Lee KH, Baik SC, Lee WK, Cho MJ, Rhee KH

Helicobacter pylori are a capnophilic bacterium, which colonize gastric mucosa and are resistant to acidic and oxidative damage. Thiol-active proteins subserve redox functions in tolerating oxidative stress and environmental toxicants,...
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Staphylococcus aureus Membrane Vesicles and Its Potential Role in Bacterial Pathogenesis

Lee JC

The production of extracellular vesicles is a ubiquitous process in both Gram-negative and Gram-positive bacteria. Gram-negative bacteria produce and secrete outer membrane vesicles during in vitro culture and in vivo...
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Comparison of Proteome Components of Helicobacter pylori Before and After Mouse Passage

Lee KJ, Kim BR, Cho YA, Song YG, Song JY, Lee KH, Kang HL, Baik SC, Cho MJ, Rhee KH, Seo JH, Youn HS, Lee WK

The mouse model is alleged to be a useful tool for understanding of pathophysiological roles of Helicobacter pylori in the development of gastric disorders. However, it has been observed that...
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Comparative Analysis of Serum Proteomes of Moyamoya Disease and Normal Controls

Koh EJ, Kim HN, Ma TZ, Choi HY, Kwak YG

OBJECTIVE: The etiology and pathogenesis of moyamoya disease remain unclear. Furthermore, the definitive diagnostic protein-biomarkers for moyamoya disease are still unknown. The present study analyzed serum proteomes from normal controls...
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Possible Roles of LAMMER Kinase Lkh1 in Fission Yeast by Comparative Proteome Analysis

Cho SJ, Kim YH, Park HM, Shin KS

  • KMID: 2312575
  • Mycobiology.
  • 2010 Jun;38(2):108-112.
To investigate the possible roles of LAMMER kinase homologue, Lkh1, in Schizosaccharomyces pombe, whole proteins were extracted from wild type and lkh1-deletion mutant cells and subjected to polyacrylamide gel electrophoresis....
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Membrane Proteome Analysis of Cerulein-Stimulated Pancreatic Acinar Cells: Implication for Early Event of Acute Pancreatitis

Lee J, Seo JH, Lim JW, Kim H

  • KMID: 2167210
  • Gut Liver.
  • 2010 Mar;4(1):84-93.
BACKGROUND/AIMS: Cerulein pancreatitis is similar to human edematous pancreatitis with dysregulation of the production and secretion of digestive enzymes, edema formation, cytoplasmic vacuolization and the death of acinar cells. We...
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Rapamycin-Induced Abundance Changes in the Proteome of Budding Yeast

Shin CS, Chang YJ, Lee HG, Huh WK

  • KMID: 2166467
  • Genomics Inform.
  • 2009 Dec;7(4):203-207.
The target of rapamycin (TOR) signaling pathway conserved from yeast to human plays critical roles in regulation of eukaryotic cell growth. It has been shown that TOR pathway is involved...
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