- Protein Kinase CK2 Modulates the Calcium Sensitivity of Type 3 Small-conductance Calcium-activated Potassium Channels in Colonic Platelet-derived Growth Factor Receptor Alpha-positive Cells From Streptozotocin-induced Diabetic Mice
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Song NN, Huang X, Lu HL, Lu C, Chen J, Xu WX
- KMID: 2541577
- J Neurogastroenterol Motil.
- 2023 Apr;29(2):250-261.
- doi: 10.5056/jnm22052
Background/Aims The gastrointestinal symptom of diabetes mellitus, chronic constipation, seriously affects patients’ life. Whereas, the mechanism of chronic constipation is still ambiguous, resulting in a lack of effective therapies for this... -
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- Inhibition of angiotensin converting enzyme increases PKCβI isoform expression via activation of substance P and bradykinin receptors in cultured astrocytes of mice
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Choi JG, Choi SR, Kang DW, Shin HJ, Lee M, Hwang J, Kim HW
- KMID: 2541334
- J Vet Sci.
- 2023 Mar;24(2):e26.
- doi: 10.4142/jvs.22275
Background: Angiotensin-converting enzyme inhibitor (ACEi) inhibits the catalysis of angiotensin I to angiotensin II and the degradation of substance P (SP) and bradykinin (BK). While the possible relationship between ACEi... -
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- The WNT/Ca2+ pathway promotes atrial natriuretic peptide secretion by activating protein kinase C/transforming growth factor-β activated kinase 1/activating transcription factor 2 signaling in isolated beating rat atria
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Li Zy, Liu Y, Han Zn, Li X, Wang Yy, Cui X, Zhang Y
- KMID: 2534523
- Korean J Physiol Pharmacol.
- 2022 Nov;26(6):469-478.
- doi: 10.4196/kjpp.2022.26.6.469
WNT signaling plays an important role in cardiac development, but abnormal activity is often associated with cardiac hypertrophy, myocardial infarction, remodeling, and heart failure. The effect of WNT signaling on... -
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- Extraneural CGRP Upregulates TGF-β1 through RAMP1 Signaling during Mechanical Stretch in Kidney Proximal Tubule Epithelial Cells
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Moon D, Padanilam BJ, Jang HS, Kim J
- KMID: 2510218
- Anat Biol Anthropol.
- 2020 Dec;33(4):173-180.
- doi: 10.11637/aba.2020.33.4.173
Calcitonin gene-related peptide (CGRP) derived from sensory neurons contributes to the development of renal tubulointerstitial fibrosis during ureteral obstruction through upregulation of profibrotic factors. However, the mechanism by which CGRP... -
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- Identification of phospholipase C β downstream effect on transient receptor potential canonical 1/4, transient receptor potential canonical 1/5 channels
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Ko J, Myeong J, Kwak M, Jeon JH, So I
- KMID: 2455812
- Korean J Physiol Pharmacol.
- 2019 Sep;23(5):357-366.
- doi: 10.4196/kjpp.2019.23.5.357
Gα(q)-coupled receptor stimulation was implied in the activation process of transient receptor potential canonical (TRPC)1/4 and TRPC1/5 heterotetrameric channels. The inactivation occurs due to phosphatidylinositol 4,5-biphosphate (PI(4,5)P₂) depletion. When PI(4,5)P₂... -
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- Protein Kinase C Activity and Delayed Recovery of Sleep-Wake Cycle in Mouse Model of Bipolar Disorder
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Moon E, Choe BM, Park JM, Chung YI, Lee BD, Park JH, Lee YM, Jeong HJ, Cheon Y, Choi Y, Park J
- KMID: 2424024
- Psychiatry Investig.
- 2018 Sep;15(9):907-913.
- doi: 10.30773/pi.2018.05.23
OBJECTIVE: Previous studies reported the delayed recovery group after circadian rhythm disruption in mice showed higher quinpiroleinduced locomotor activity. This study aimed to compare not only Protein Kinase C (PKC)... -
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- Sustained Intracellular Acidosis Triggers the Naâº/H⺠Exchager-1 Activation in Glutamate Excitotoxicity
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Lee BK, Jung YS
- KMID: 2395808
- Biomol Ther.
- 2017 Nov;25(6):593-598.
- doi: 10.4062/biomolther.2017.018
The Naâº/H⺠exchanger-1 (NHE-1) is a ubiquitously expressed pH-regulatory membrane protein that functions in the brain, heart, and other organs. It is increased by intracellular acidosis through the interaction of... -
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- Biphasic augmentation of alpha-adrenergic contraction by plumbagin in rat systemic arteries
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Kim HJ, Yoo HY, Zhang YH, Kim WK, Kim SJ
- KMID: 2395264
- Korean J Physiol Pharmacol.
- 2017 Nov;21(6):687-694.
- doi: 10.4196/kjpp.2017.21.6.687
Plumbagin, a hydroxy 1,4-naphthoquinone compound from plant metabolites, exhibits anticancer, antibacterial, and antifungal activities via modulating various signaling molecules. However, its effects on vascular functions are rarely studied except in... -
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- Protein Kinase C Mediates the Corticosterone-induced Sensitization of Dorsal Root Ganglion Neurons Innervating the Rat Stomach
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Li M, Xue L, Zhu HY, Wang H, Xu X, Zhang PA, Wu G, Xu GY
- KMID: 2387838
- J Neurogastroenterol Motil.
- 2017 Jul;23(3):464-476.
- doi: 10.5056/jnm16161
BACKGROUND/AIMS: Gastric hypersensitivity contributes to abdominal pain in patients with functional dyspepsia. Recent studies showed that hormones induced by stress are correlated with visceral hypersensitivity. However, the precise mechanisms underlying... -
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- Protein kinase C beta II upregulates intercellular adhesion molecule-1 via mitochondrial activation in cultured endothelial cells
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Joo HK, Lee YR, Choi S, Park MS, Kang G, Kim CS, Jeon BH
- KMID: 2384451
- Korean J Physiol Pharmacol.
- 2017 Jul;21(4):377-384.
- doi: 10.4196/kjpp.2017.21.4.377
Activation of protein kinase C (PKC) is closely linked with endothelial dysfunction. However, the effect of PKCβII on endothelial dysfunction has not been characterized in cultured endothelial cells. Here, using... -
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- Biflorin Ameliorates Memory Impairments Induced by Cholinergic Blockade in Mice
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Jeon SJ, Kim B, Ryu B, Kim E, Lee S, Jang DS, Ryu JH
- KMID: 2378802
- Biomol Ther.
- 2017 May;25(3):249-258.
- doi: 10.4062/biomolther.2016.058
To examine the effect of biflorin, a component of Syzygium aromaticum, on memory deficit, we introduced a scopolamine-induced cognitive deficit mouse model. A single administration of biflorin increased latency time... -
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- Alkyl Cinnamates Induce Protein Kinase C Translocation and Anticancer Activity against Breast Cancer Cells through Induction of the Mitochondrial Pathway of Apoptosis
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Deka SJ, Mamdi N, Manna D, Trivedi V
- KMID: 2362922
- J Breast Cancer.
- 2016 Dec;19(4):358-371.
- doi: 10.4048/jbc.2016.19.4.358
PURPOSE: The protein kinase C (PKC) family of serine-threonine kinases plays an important role in cancer cell progression. Thus, molecules that target PKC have potential as anticancer agents. The current... -
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- Involvement of Protein Kinase C-delta in Vascular Permeability in Acute Lung Injury
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Ahn JJ, Jung JP, Park SE, Lee M, Kwon B, Cho HR
- KMID: 2168048
- Immune Netw.
- 2015 Aug;15(4):206-211.
- doi: 10.4110/in.2015.15.4.206
Pulmonary edema is a major cause of mortality due to acute lung injury (ALI). The involvement of protein kinase C-delta (PKC-delta) in ALI has been a controversial topic. Here we... -
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- Amoebic PI3K and PKC Is Required for Jurkat T Cell Death Induced by Entamoeba histolytica
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Lee YA, Kim KA, Min A, Shin MH
- KMID: 1792196
- Korean J Parasitol.
- 2014 Aug;52(4):355-365.
- doi: 10.3347/kjp.2014.52.4.355
The enteric protozoan parasite Entamoeba histolytica is the causative agent of human amebiasis. During infection, adherence of E. histolytica through Gal/GalNAc lectin on the surface of the amoeba can induce... -
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- Ruboxistaurin for the Treatment of Diabetic Peripheral Neuropathy: A Systematic Review of Randomized Clinical Trials
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Bansal D, Badhan Y, Gudala K, Schifano F
- KMID: 1965985
- Diabetes Metab J.
- 2013 Oct;37(5):375-384.
- doi: 10.4093/dmj.2013.37.5.375
BACKGROUND: Diabetic peripheral neuropathy (DPN) is a common complication of diabetes mellitus. Protein kinase C (PKC) inhibitor's has been thought to be a potential disease modifying drug's in DPN as... -
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- Swiprosin-1 Expression Is Up-Regulated through Protein Kinase C-theta and NF-kappaB Pathway in T Cells
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Kim YD, Kwon MS, Na BR, Kim HR, Lee HS, Jun CD
- KMID: 1431926
- Immune Netw.
- 2013 Apr;13(2):55-62.
- doi: 10.4110/in.2013.13.2.55
Swiprosin-1 exhibits the highest expression in CD8+ T cells and immature B cells and has been proposed to play a role in lymphocyte biology through actin remodeling. However, regulation of... -
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- Phorbol 12-Myristate 13-Acetate Enhances Long-Term Potentiation in the Hippocampus through Activation of Protein Kinase Cdelta and epsilon
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Kim EC, Lee MJ, Shin SY, Seol GH, Han SH, Yee J, Kim C, Min SS
- KMID: 1432763
- Korean J Physiol Pharmacol.
- 2013 Feb;17(1):51-56.
- doi: 10.4196/kjpp.2013.17.1.51
Many intracellular proteins and signaling cascades contribute to the sensitivity of N-methyl-D-aspartate receptors (NMDARs). One such putative contributor is the serine/threonine kinase, protein kinase C (PKC). Activation of PKC by... -
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- The Role of Oxidative Stress in the Pathogenesis of Diabetic Vascular Complications
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Sasaki S, Inoguchi T
- KMID: 2174415
- Diabetes Metab J.
- 2012 Aug;36(4):255-261.
- doi: 10.4093/dmj.2012.36.4.255
Oxidative stress has been paid increasing attention to as an important causative factor for diabetic vascular complications. Among possible various sources, accumulating evidence has indicated that NAD(P)H oxidase may be... -
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- Chlorination of ortho-position on Polychlorinated Biphenyls Increases Protein Kinase C Activity in Neuronal Cells
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Lee YJ, Yang JH
- KMID: 1432247
- Toxicol Res.
- 2012 Jun;28(2):107-112.
Polychlorinated biphenyls (PCBs) are persistent and bioaccumulative environmental pollutants. Recently, it is suggested that neurotoxic effects such as motor dysfunction and impairment in memory and learning have been associated with... -
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- Effects of Polychlorinated Biphenyls on the Development of Neuronal Cells in Growth Period; Structure-Activity Relationship
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Do Y, Lee DK
- KMID: 2165388
- Exp Neurobiol.
- 2012 Mar;21(1):30-36.
- doi: 10.5607/en.2012.21.1.30
Polychlorinated biphenyls (PCBs) are accumulated in our body through food chain and cause a variety of adverse health effects including neurotoxicities such as cognitive deficits and motor dysfunction. In particular,... -
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